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Content archived on 2024-05-29

Active manipulation of Biomolecules in microfluidic arrays

Objective

The proposed research deals with the problem of sorting and separating biomolecules using a microfluidic network of micron- or nanometre-sized channels. The flow in the network is driven by electrical potentials induced by electrodes placed at various node s of the network. We propose to carry out a comprehensive study (both analytical and computational) of the resulting electroosmotic flow (EOF) in the network in order to determine the channel configuration and the electric potential distribution required t o propel different sized molecules to exit through different outlet channels.

The essentially flat velocity profile of EOF should provide higher resolution and much quicker process times than the traditional method of gel eletrophoretic separation. A novel feature that we are proposing is to employ slowly converging inlet channels (for reducing the entropic forces) and slowly diverging outlet channels (for ease of collecting the separated molecules). Our ultimate aim is to integrate the computational scheme we develop with micro-fabrication procedures to rapidly prototype custom-designed channel configurations for particular applications.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP6-2002-MOBILITY-7
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

IIF - Marie Curie actions-Incoming International Fellowships

Coordinator

SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA
EU contribution
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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