Project description
A novel target for malaria treatment
Malaria remains one of the most prevalent parasitic diseases. The emergence and spread of drug-resistant parasites threatens existing treatments and necessitates the constant development of anti-malaria drugs against new targets. The EU-funded SUBUN project will direct inhibitor development towards the Plasmodium-specific subtilisin SUB1, a protease implicated in the egress of the parasite from human infected cells. Researchers combining expertise in medicinal chemistry, biochemistry, structural biology and parasitology aim at identifying potent and selective SUB1 inhibitors, which are expected to have both prophylactic and therapeutic values. Most importantly, they will be able to target all stages of the parasite life cycle, fulfilling the WHO criteria on antimalaria agents.
Fields of science
Programme(s)
Funding Scheme
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
Coordinator
75794 Paris
France
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