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Engineering substrate-based inhibitors of Plasmodium SUB1, a potential target for Malaria treatment.

Project description

A novel target for malaria treatment

Malaria remains one of the most prevalent parasitic diseases. The emergence and spread of drug-resistant parasites threatens existing treatments and necessitates the constant development of anti-malaria drugs against new targets. The EU-funded SUBUN project will direct inhibitor development towards the Plasmodium-specific subtilisin SUB1, a protease implicated in the egress of the parasite from human infected cells. Researchers combining expertise in medicinal chemistry, biochemistry, structural biology and parasitology aim at identifying potent and selective SUB1 inhibitors, which are expected to have both prophylactic and therapeutic values. Most importantly, they will be able to target all stages of the parasite life cycle, fulfilling the WHO criteria on antimalaria agents.

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Net EU contribution
€ 196 707,84
Address
Rue Michel Ange 3
75794 Paris
France

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00