Project description
Unveiling the mysteries of ageing
There are many theories on the underlying mechanisms of cellular ageing implicating DNA damage as well as oxidative damage to proteins. However, the precise aetiology remains poorly understood. The scope of the EU-funded CarboPore project is to investigate the contribution of oxidatively damaged proteins to cellular ageing. Researchers will work under the hypothesis that age-associated protein aggregates cause membrane damage and permeabilisation. For this purpose, they will assess the impact of protein aggregates on cellular membrane integrity using advanced imaging and biochemical techniques. The project's results will unveil novel cellular and molecular aspects of ageing, shedding light on this complex process.
Fields of science
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- natural sciencesphysical sciencesopticsmicroscopy
- natural sciencesbiological sciencesbiochemistrybiomoleculeslipids
- natural scienceschemical sciencesanalytical chemistrymass spectrometry
- natural sciencesphysical sciencesopticsspectroscopy
Programme(s)
Funding Scheme
MSCA-IF-EF-RI - RI – Reintegration panel
Coordinator
21000 Split
Croatia
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