Deciphering the mechanism of cellular aging: interaction of oxidatively damaged proteins with the cellular membranes

Project description

Unveiling the mysteries of ageing

There are many theories on the underlying mechanisms of cellular ageing implicating DNA damage as well as oxidative damage to proteins. However, the precise aetiology remains poorly understood. The scope of the EU-funded CarboPore project is to investigate the contribution of oxidatively damaged proteins to cellular ageing. Researchers will work under the hypothesis that age-associated protein aggregates cause membrane damage and permeabilisation. For this purpose, they will assess the impact of protein aggregates on cellular membrane integrity using advanced imaging and biochemical techniques. The project's results will unveil novel cellular and molecular aspects of ageing, shedding light on this complex process.

Fields of science

• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• natural sciences › physical sciences › optics › microscopy
• natural sciences › biological sciences › biochemistry › biomolecules › lipids
• natural sciences › chemical sciences › analytical chemistry › mass spectrometry
• natural sciences › physical sciences › optics › spectroscopy

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2019 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2019

See other projects for this call

Funding Scheme

MSCA-IF-EF-RI - RI – Reintegration panel

Coordinator

MEDITERANSKI INSTITUT ZA ISTRAZIVANJE ZIVOTA

Net EU contribution

€ 147 463,68

Address

Mestrovicevo Setaliste 45
21000 Split
Croatia

Region

Hrvatska › Jadranska Hrvatska › Splitsko-dalmatinska županija

Activity type

Research Organisations

Links

Other funding

€ 0,00