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Deciphering the mechanism of cellular aging: interaction of oxidatively damaged proteins with the cellular membranes

Project description

Unveiling the mysteries of ageing

There are many theories on the underlying mechanisms of cellular ageing implicating DNA damage as well as oxidative damage to proteins. However, the precise aetiology remains poorly understood. The scope of the EU-funded CarboPore project is to investigate the contribution of oxidatively damaged proteins to cellular ageing. Researchers will work under the hypothesis that age-associated protein aggregates cause membrane damage and permeabilisation. For this purpose, they will assess the impact of protein aggregates on cellular membrane integrity using advanced imaging and biochemical techniques. The project's results will unveil novel cellular and molecular aspects of ageing, shedding light on this complex process.

Coordinator

MEDITERANSKI INSTITUT ZA ISTRAZIVANJE ZIVOTA
Net EU contribution
€ 147 463,68
Address
Mestrovicevo Setaliste 45
21000 Split
Croatia

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Region
Hrvatska Jadranska Hrvatska Splitsko-dalmatinska županija
Activity type
Research Organisations
Other funding
€ 0,00