Objective
Dendritic cells (DC) are highly specialized antigen presenting cells that link the innate and adaptive immunity. DC are heterogeneous and may be subdivided into multiple subsets.
This heterogeneity may be coupled to functional diversity but the role of each subset remains controversial: although some DC functions appear to be subset-specific, e.g. IFN alpha secretion by plasmacytoid DC or cross-presentation by mouse CD8alpha+ DC, several stimuli can overcome subset-specific restrictions indicating that DC subsets possess significant functional plasticity.
Nevertheless, the differential expression of many receptors by DC subsets may underlie a distinct pattern of pathogen recognition or of cellular interactions. In an attempt to explore this issue, the host laboratory has undertaken representational difference analysis of murine CD8alpha+ and CD8alpha- subsets.
This technique allowed them to identify a novel C-type lectin encoded in the NK complex that is selectively expressed in CD8alpha+ DC. The purpose of this project is the functional characterization of this unknown protein, provisionally termed 'CLECT-X'. We will confirm its restricted expression to CD8alpha+ DC, and will study its functional behaviour in vitro and in vivo.
By understanding the role of this differentially-expressed molecule, we hope to increase our understanding of DC subsets and create new tools to modulate DC in diseases such as cancer, autoimmunity, or infection.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology skin cancer melanoma
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine immunology immunotherapy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.