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How dendritic mRNA and protein distributions shape synaptic plasticity

Project description

Solving the puzzle of synaptic protein numbers regulation

Neurons regulate dendritic protein numbers and redistribute proteins in response to synaptic changes. However, the way the available pool of proteins is redistributed via diffusion or active trafficking and how synaptic protein numbers are modified by increased translation of local mRNAs is a mystery. The EU-funded MolDynForSyn project aims to develop a data-driven theory describing the dendritic mRNA and protein distributions and use it to study the synaptic plasticity dynamics in dendrites and their impact on memory storage. The unique combination of theoretical and experimental data will result in a better understanding of long-term memory mechanisms and many neurological diseases associated with neuronal trafficking pathologies or protein synthesis dysfunction.

Host institution

UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
Net EU contribution
€ 1 469 625,00
Address
Langenbeckstrasse 1
55131 Mainz
Germany

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Region
Rheinland-Pfalz Rheinhessen-Pfalz Mainz, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Beneficiaries (2)

UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
Germany
Net EU contribution
€ 1 469 625,00
Address
Langenbeckstrasse 1
55131 Mainz

See on map

Region
Rheinland-Pfalz Rheinhessen-Pfalz Mainz, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Participation ended

Germany
Net EU contribution
€ 0,00
Address
Hofgartenstrasse 8
80539 Munchen
Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Other funding
€ 0,00