Project description
Solving the puzzle of synaptic protein numbers regulation
Neurons regulate dendritic protein numbers and redistribute proteins in response to synaptic changes. However, the way the available pool of proteins is redistributed via diffusion or active trafficking and how synaptic protein numbers are modified by increased translation of local mRNAs is a mystery. The EU-funded MolDynForSyn project aims to develop a data-driven theory describing the dendritic mRNA and protein distributions and use it to study the synaptic plasticity dynamics in dendrites and their impact on memory storage. The unique combination of theoretical and experimental data will result in a better understanding of long-term memory mechanisms and many neurological diseases associated with neuronal trafficking pathologies or protein synthesis dysfunction.
Fields of science
Programme(s)
Topic(s)
Funding Scheme
ERC-STG - Starting Grant
Host institution
55131 Mainz
Germany
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Beneficiaries (2)
55131 Mainz
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Participation ended
80539 Munchen