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Stem cell isolation and transplantation in Hexacorallia: Toward cell-therapy for corals

Project description

Cell therapy for the rescue of coral reefs

Coral reefs are the cornerstones of ocean ecosystems that support much of the ocean's biodiversity. Due to anthropogenic stress factors, they are under severe threat. Mitigation efforts should be based on transferring naturally-occurring resilient genotypes. The EU-funded CoralStem project aims to develop generalised strategies for the isolation, characterisation and transplantation of coral progenitor cells using four species of anemones and stony corals. The objective is to develop cell transplantation techniques for engraftment in non-model species. The possibility to transfer progenitor cells from a stress-resilient coral to a sensitive one will provide an understanding of the tolerance mechanisms and the possibility to confer resilience in the wild coral ecosystems.

Objective

Reef corals are the foundation of ecosystems that host much of the ocean’s biodiversity, making them a significant component of economies and communities around the world. They are under severe threat from anthropogenic stressors, particularly global warming. Some parts of the world’s oceans have already lost the majority of their corals.
Efforts to mitigate the damage are informed by research on understanding and transferring naturally-occurring resilient genotypes. This has a direct parallel in medicine; cell- or gene-therapy, which is founded on an ability to isolate and then transplant progenitor/stem cells. This technology does not exist for any coral species.
In this research program we will develop robust tools for the isolation, characterization, and transplantation of coral progenitor cells. The tools will be species non-specific, and therefore widely applicable.
We will develop generalized strategies for isolating cell-type enriched cell populations, especially progenitor cells, in four species of anemones and stony corals. We will develop cell transplantation techniques for engraftment in non-model species. We will then characterize the engraftment potentials of candidate progenitor cell populations in these species.
This technology will have an impact on basic and applied research. Because of the broad applicability, it will become a valuable tool for researchers seeking a more complete cell biology in non-classical invertebrate species. Being able to isolate, manipulate, and replace progenitor cells in diverse species will assist in efforts to understand how the developmental programs that construct or regenerate an organism function and change during evolution. Being able to transfer progenitor cells from a stress-resilient coral to a sensitive one will assist in understanding the mechanisms governing stress tolerance. With this research, and using the tools developed here, it may become possible to confer resilience in the wild.

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Programme(s)

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Topic(s)

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Funding Scheme

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ERC-STG - Starting Grant

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Call for proposal

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(opens in new window) ERC-2020-STG

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Host institution

BEN-GURION UNIVERSITY OF THE NEGEV
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 2 045 900,00
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 2 045 900,00

Beneficiaries (1)

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