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Do liquid crystal-like phases of proteins organize membrane compartments?

Project description

Protein assembly in organelle organisation: is it time to revisit the history of biology?

We know that intracellular organisation into organelles relies on the formation of lipid bilayers and allows cells to compartmentalise different processes. However, the existence of non-membrane bound compartments, such as nucleoli, raises the question of how cells keep such regions distinct and prevent their context from mixing with the surroundings. The EU-funded LiquOrg project will challenge the concept that membrane-less organelles are formed by liquid-liquid phase separation and proposes a liquid crystal hypothesis where surface proteins organise into multiple layers which surround and enclose their membranes. Researchers will use the Golgi apparatus and the golgin proteins as proof of concept.

Call for proposal

ERC-2020-SyG
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Host institution

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Address
Rue Michel Ange 3
75794 Paris
France
Activity type
Other
EU contribution
€ 2 922 775

Beneficiaries (4)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 2 922 775
Address
Rue Michel Ange 3
75794 Paris
Activity type
Other
FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain
EU contribution
€ 2 421 410
Address
Carrer Doctor Aiguader 88
08003 Barcelona
Activity type
Research Organisations
UNIVERSIDAD COMPLUTENSE DE MADRID
Spain
EU contribution
€ 2 553 940
Address
Avenida De Seneca 2
28040 Madrid
Activity type
Higher or Secondary Education Establishments
UNIVERSITY COLLEGE LONDON
United Kingdom
EU contribution
€ 3 339 375
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments