Deliverables Websites, patent fillings, videos etc. (3) Dissemination of ERA Chair holder position Dissemination of ERA Chair holder position including social media channels Publication of the ERA Chair position announcement Publication of the ERA Chair position announcement EURAXESS reference scientific journals Webpage of the project Webpage of the project Publications Peer reviewed articles (65) The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples Author(s): Diana Duarte Lobo, Rui Jorge Nobre, Catarina Oliveira Miranda, Dina Pereira, João Castelhano, José Sereno, Arnulf Koeppen, Miguel Castelo-Branco, Luís Pereira de Almeida Published in: Acta Neuropathologica Communications, Issue 8/1, 2020, ISSN 2051-5960 Publisher: BioMed Central DOI: 10.1186/s40478-020-00955-0 Adenosine A2A receptors format long-term depression and memory strategies in a mouse model of Angelman syndrome Author(s): Ana Moreira-de-Sá, Francisco Q. Gonçalves, João P. Lopes, Henrique B. Silva, Ângelo R. Tomé, Rodrigo A. Cunha, Paula M. Canas Published in: Neurobiology of Disease, Issue 146, 2020, Page(s) 105137, ISSN 0969-9961 Publisher: Academic Press DOI: 10.1016/j.nbd.2020.105137 Meningeal γδ T cell–derived IL-17 controls synaptic plasticity and short-term memory Author(s): Miguel Ribeiro, Helena C. Brigas, Mariana Temido-Ferreira, Paula A. Pousinha, Tommy Regen, Cátia Santa, Joana E. Coelho, Inês Marques-Morgado, Cláudia A. Valente, Sara Omenetti, Brigitta Stockinger, Ari Waisman, Bruno Manadas, Luísa V. Lopes, Bruno Silva-Santos, Julie C. Ribot Published in: Science Immunology, Issue 4/40, 2019, Page(s) eaay5199, ISSN 2470-9468 Publisher: AMER ASSOC ADVANCEMENT SCIENCE DOI: 10.1126/sciimmunol.aay5199 Signaling by adenosine receptors—Homeostatic or allostatic control? Author(s): Rodrigo A. Cunha Published in: PLOS Biology, Issue 17/4, 2019, Page(s) e3000213, ISSN 1545-7885 Publisher: PUBLIC LIBRARY SCIENCE DOI: 10.1371/journal.pbio.3000213 Disrupted AMPA Receptor Function upon Genetic- or Antibody-Mediated Loss of Autism-Associated CASPR2 Author(s): Dominique Fernandes, Sandra D Santos, Ester Coutinho, Jessica L Whitt, Nuno Beltrão, Tiago Rondão, M Isabel Leite, Camilla Buckley, Hey-Kyoung Lee, Ana Luísa Carvalho Published in: Cerebral Cortex, Issue 29/12, 2019, Page(s) 4919-4931, ISSN 1047-3211 Publisher: Oxford University Press DOI: 10.1093/cercor/bhz032 Diabetes–Alzheimer's Disease Link: Targeting Mitochondrial Dysfunction and Redox Imbalance Author(s): Cristina Carvalho, Susana Cardoso Published in: Antioxidants & Redox Signaling, 2020, ISSN 1523-0864 Publisher: Mary Ann Liebert Inc. DOI: 10.1089/ars.2020.8056 BDNF increases synaptic NMDA receptor abundance by enhancing the local translation of Pyk2 in cultured hippocampal neurons Author(s): Pedro Afonso, Pasqualino De Luca, Rafael S. Carvalho, Luísa Cortes, Paulo Pinheiro, Barbara Oliveiros, Ramiro D. Almeida, Miranda Mele, Carlos B. Duarte Published in: Science Signaling, Issue 12/586, 2019, Page(s) eaav3577, ISSN 1937-9145 Publisher: American Association for the Advancement of Science DOI: 10.1126/scisignal.aav3577 A longitudinal multimodal in vivo molecular imaging study of the 3xTg-AD mouse model shows progressive early hippocampal and taurine loss Author(s): Samuel Chiquita, Mário Ribeiro, João Castelhano, Francisco Oliveira, José Sereno, Marta Batista, Antero Abrunhosa, Ana C Rodrigues-Neves, Rafael Carecho, Filipa Baptista, Catarina Gomes, Paula I Moreira, António F Ambrósio, Miguel Castelo-Branco Published in: Human Molecular Genetics, Issue 28/13, 2019, Page(s) 2174-2188, ISSN 0964-6906 Publisher: Oxford University Press DOI: 10.1093/hmg/ddz045 Enhanced ATP release and CD73‐mediated adenosine formation sustain adenosine A 2A receptor over‐activation in a rat model of Parkinson's disease Author(s): Marta Carmo, Francisco Q. Gonçalves, Paula M. Canas, Jean‐Pierre Oses, Francisco D. Fernandes, Filipe V. Duarte, Carlos M. Palmeira, Angelo R. Tomé, Paula Agostinho, Geanne M. Andrade, Rodrigo A. Cunha Published in: British Journal of Pharmacology, Issue 176/18, 2019, Page(s) 3666-3680, ISSN 0007-1188 Publisher: Wiley-Blackwell DOI: 10.1111/bph.14771 Transcriptional consequences of MBD5 disruption in mouse brain and CRISPR-derived neurons Author(s): Catarina M. Seabra, Tatsiana Aneichyk, Serkan Erdin, Derek J. C. Tai, Celine E. F. De Esch, Parisa Razaz, Yu An, Poornima Manavalan, Ashok Ragavendran, Alexei Stortchevoi, Clemer Abad, Juan I. Young, Patricia Maciel, Michael E. Talkowski, James F. Gusella Published in: Molecular Autism, Issue 11/1, 2020, ISSN 2040-2392 Publisher: BioMed Central DOI: 10.1186/s13229-020-00354-1 Neuronal adenosine A2A receptors signal ergogenic effects of caffeine Author(s): Aderbal S. Aguiar, Ana Elisa Speck, Paula M. Canas, Rodrigo A. Cunha Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-020-69660-1 Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice Author(s): Mohamed Edfawy, Joana R. Guedes, Marta I. Pereira, Mariana Laranjo, Mário J. Carvalho, Xian Gao, Pedro A. Ferreira, Gladys Caldeira, Lara O. Franco, Dongqing Wang, Ana Luisa Cardoso, Guoping Feng, Ana Luisa Carvalho, João Peça Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-019-09382-9 Neurofilaments in spinocerebellar ataxia type 3: blood biomarkers at the preataxic and ataxic stage in humans and mice Author(s): Carlo Wilke, Eva Haas, Kathrin Reetz, Jennifer Faber, Hector Garcia‐Moreno, Magda M Santana, Bart Warrenburg, Holger Hengel, Manuela Lima, Alessandro Filla, Alexandra Durr, Bela Melegh, Marcella Masciullo, Jon Infante, Paola Giunti, Manuela Neumann, Jeroen Vries, Luis Pereira de Almeida, Maria Rakowicz, Heike Jacobi, Rebecca Schüle, Stephan A Kaeser, Jens Kuhle, Thomas Klockgether, Ludger Schö Published in: EMBO Molecular Medicine, Issue 12/7, 2020, ISSN 1757-4676 Publisher: John Wiley & Sons Ltd. DOI: 10.15252/emmm.201911803 Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia Author(s): Clévio Nóbrega, Liliana Mendonça, Adriana Marcelo, Antonin Lamazière, Sandra Tomé, Gaetan Despres, Carlos A. Matos, Fatich Mechmet, Dominique Langui, Wilfred den Dunnen, Luis Pereira de Almeida, Nathalie Cartier, Sandro Alves Published in: Acta Neuropathologica, Issue 138/5, 2019, Page(s) 837-858, ISSN 0001-6322 Publisher: Springer Verlag DOI: 10.1007/s00401-019-02019-7 Differential protein expression in diverse brain areas of Parkinson’s and Alzheimer’s disease patients Author(s): A. R. Esteves, S. M. Cardoso Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-020-70174-z A nanoformulation for the preferential accumulation in adult neurogenic niches Author(s): Catarina Praça, Akhilesh Rai, Tiago Santos, Ana C. Cristovão, Sonia L. Pinho, Romeo Cecchelli, Marie-Pierre Dehouck, Liliana Bernardino, Lino S. Ferreira Published in: Journal of Controlled Release, Issue 284, 2018, Page(s) 57-72, ISSN 0168-3659 Publisher: Elsevier BV DOI: 10.1016/j.jconrel.2018.06.013 Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors Author(s): Mariana Temido-Ferreira, Diana G. Ferreira, Vânia L. Batalha, Inês Marques-Morgado, Joana E. Coelho, Pedro Pereira, Rui Gomes, Andreia Pinto, Sara Carvalho, Paula M. Canas, Laetitia Cuvelier, Valerie Buée-Scherrer, Emilie Faivre, Younis Baqi, Christa E. Müller, José Pimentel, Serge N. Schiffmann, Luc Buée, Michael Bader, Tiago F. Outeiro, David Blum, Rodrigo A. Cunha, Hélène Marie, Paula A Published in: Molecular Psychiatry, Issue 25/8, 2020, Page(s) 1876-1900, ISSN 1359-4184 Publisher: Nature Publishing Group DOI: 10.1038/s41380-018-0110-9 MicroRNA-186-5p controls GluA2 surface expression and synaptic scaling in hippocampal neurons Author(s): Mariline M. Silva, Beatriz Rodrigues, Joana Fernandes, Sandra D. Santos, Laura Carreto, Manuel A. S. Santos, Paulo Pinheiro, Ana Luísa Carvalho Published in: Proceedings of the National Academy of Sciences, Issue 116/12, 2019, Page(s) 5727-5736, ISSN 0027-8424 Publisher: National Academy of Sciences DOI: 10.1073/pnas.1900338116 The importance of determining circadian parameters in pharmacological studies Author(s): Laetitia S. Gaspar, Ana Rita Álvaro, Sara Carmo‐Silva, Alexandrina Ferreira Mendes, Angela Relógio, Cláudia Cavadas Published in: British Journal of Pharmacology, Issue 176/16, 2019, Page(s) 2827-2847, ISSN 0007-1188 Publisher: Wiley-Blackwell DOI: 10.1111/bph.14712 Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study Author(s): Rita Guerreiro, Owen A Ross, Celia Kun-Rodrigues, Dena G Hernandez, Tatiana Orme, John D Eicher, Claire E Shepherd, Laura Parkkinen, Lee Darwent, Michael G Heckman, Sonja W Scholz, Juan C Troncoso, Olga Pletnikova, Olaf Ansorge, Jordi Clarimon, Alberto Lleo, Estrella Morenas-Rodriguez, Lorraine Clark, Lawrence S Honig, Karen Marder, Afina Lemstra, Ekaterina Rogaeva, Peter St George-Hyslop, Elisabe Published in: The Lancet Neurology, Issue 17/1, 2018, Page(s) 64-74, ISSN 1474-4422 Publisher: The Lancet Publishing Group DOI: 10.1016/s1474-4422(17)30400-3 Derivation of Brain Capillary-like Endothelial Cells from Human Pluripotent Stem Cell-Derived Endothelial Progenitor Cells Author(s): Catarina Praça, Susana C. Rosa, Emmanuel Sevin, Romeo Cecchelli, Marie-Pierre Dehouck, Lino S. Ferreira Published in: Stem Cell Reports, Issue 13/4, 2019, Page(s) 599-611, ISSN 2213-6711 Publisher: Cell Press DOI: 10.1016/j.stemcr.2019.08.002 Clinical validation of the Lumipulse G cerebrospinal fluid assays for routine diagnosis of Alzheimer’s disease Author(s): Maria João Leitão, Anuschka Silva-Spínola, Isabel Santana, Veronica Olmedo, Alicia Nadal, Nathalie Le Bastard, Inês Baldeiras Published in: Alzheimer's Research & Therapy, Issue 11/1, 2019, ISSN 1758-9193 Publisher: BioMed Central DOI: 10.1186/s13195-019-0550-8 Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study Author(s): Katrina M Moore, Jennifer Nicholas, Murray Grossman, Corey T McMillan, David J Irwin, Lauren Massimo, Vivianna M Van Deerlin, Jason D Warren, Nick C Fox, Martin N Rossor, Simon Mead, Martina Bocchetta, Bradley F Boeve, David S Knopman, Neill R Graff-Radford, Leah K Forsberg, Rosa Rademakers, Zbigniew K Wszolek, John C van Swieten, Lize C Jiskoot, Lieke H Meeter, Elise GP Dopper, Janne M Papma, Jul Published in: The Lancet Neurology, Issue 19/2, 2020, Page(s) 145-156, ISSN 1474-4422 Publisher: The Lancet Publishing Group DOI: 10.1016/s1474-4422(19)30394-1 Enhanced selectivity and stability of ruthenium purple-modified carbon fiber microelectrodes for detection of hydrogen peroxide in brain tissue Author(s): Ana Ledo, Eliana Fernandes, Christopher M.A. Brett, Rui M. Barbosa Published in: Sensors and Actuators B: Chemical, Issue 311, 2020, Page(s) 127899, ISSN 0925-4005 Publisher: Elsevier BV DOI: 10.1016/j.snb.2020.127899 Differential Nanoscale Topography and Functional Role of GluN2-NMDA Receptor Subtypes at Glutamatergic Synapses Author(s): Blanka Kellermayer, Joana S. Ferreira, Julien Dupuis, Florian Levet, Dolors Grillo-Bosch, Lucie Bard, Jeanne Linarès-Loyez, Delphine Bouchet, Daniel Choquet, Dmitri A. Rusakov, Pierre Bon, Jean-Baptiste Sibarita, Laurent Cognet, Matthieu Sainlos, Ana Luisa Carvalho, Laurent Groc Published in: Neuron, Issue 100/1, 2018, Page(s) 106-119.e7, ISSN 0896-6273 Publisher: Cell Press DOI: 10.1016/j.neuron.2018.09.012 Dichotomous Sirtuins: Implications for Drug Discovery in Neurodegenerative and Cardiometabolic Diseases Author(s): Pedro Gomes, Helena Leal, Alexandrina F. Mendes, Flávio Reis, Cláudia Cavadas Published in: Trends in Pharmacological Sciences, Issue 40/12, 2019, Page(s) 1021-1039, ISSN 0165-6147 Publisher: Elsevier BV DOI: 10.1016/j.tips.2019.09.003 Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial Author(s): Scott E Kasner, Balakumar Swaminathan, Pablo Lavados, Mukul Sharma, Keith Muir, Roland Veltkamp, Sebastian F Ameriso, Matthias Endres, Helmi Lutsep, Steven R Messé, J David Spence, Krassen Nedeltechev, Kanjana Perera, Gustavo Santo, Veronica Olavarria, Arne Lindgren, Shrikant Bangdiwala, Ashkan Shoamanesh, Scott D Berkowitz, Hardi Mundl, Stuart J Connolly, Robert G Hart, N Abdelhamid, D Abdul Rah Published in: The Lancet Neurology, Issue 17/12, 2018, Page(s) 1053-1060, ISSN 1474-4422 Publisher: The Lancet Publishing Group DOI: 10.1016/s1474-4422(18)30319-3 Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells Author(s): Célia A Aveleira, Marisa Ferreira-Marques, Luísa Cortes, Jorge Valero, Dina Pereira, Luís Pereira de Almeida, Cláudia Cavadas Published in: The Journals of Gerontology: Series A, Issue 75/6, 2020, Page(s) 1073-1078, ISSN 1079-5006 Publisher: Gerontological Society of America DOI: 10.1093/gerona/glz280 Overactivity of neuronal adenosine A2A receptors accelerates neurodegeneration Author(s): Rodrigo A Cunha Published in: Brain, Issue 142/11, 2019, Page(s) 3323-3324, ISSN 0006-8950 Publisher: Oxford University Press DOI: 10.1093/brain/awz335 Dual Therapy with Liraglutide and Ghrelin Promotes Brain and Peripheral Energy Metabolism in the R6/2 Mouse Model of Huntington’s Disease Author(s): Ana I. Duarte, Marie Sjögren, Maria S. Santos, Catarina R. Oliveira, Paula I. Moreira, Maria Björkqvist Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-018-27121-w Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury Author(s): Elisa M. Floriddia, Tânia Lourenço, Shupei Zhang, David van Bruggen, Markus M. Hilscher, Petra Kukanja, João P. Gonçalves dos Santos, Müge Altınkök, Chika Yokota, Enric Llorens-Bobadilla, Sara B. Mulinyawe, Mário Grãos, Lu O. Sun, Jonas Frisén, Mats Nilsson, Gonçalo Castelo-Branco Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-020-19453-x Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin Author(s): Sindhuja Gowrisankaran, Sébastien Houy, Johanna G. Peña del Castillo, Vicky Steubler, Monika Gelker, Jana Kroll, Paulo S. Pinheiro, Dirk Schwitters, Nils Halbsgut, Arndt Pechstein, Jan R. T. van Weering, Tanja Maritzen, Volker Haucke, Nuno Raimundo, Jakob B. Sørensen, Ira Milosevic Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-020-14993-8 Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia Author(s): Willemijn J. Jansen, Rik Ossenkoppele, Betty M. Tijms, Anne M. Fagan, Oskar Hansson, William E. Klunk, Wiesje M. van der Flier, Victor L. Villemagne, Giovanni B. Frisoni, Adam S. Fleisher, Alberto Lleó, Mark A. Mintun, Anders Wallin, Sebastiaan Engelborghs, Duk L. Na, Gäel Chételat, José Luis Molinuevo, Susan M. Landau, Niklas Mattsson, Johannes Kornhuber, Osama Sabri, Christopher C. Rowe, Luc Published in: JAMA Psychiatry, Issue 75/1, 2018, Page(s) 84, ISSN 2168-622X Publisher: American Medical Association DOI: 10.1001/jamapsychiatry.2017.3391 Adenosine A 1 and A 2A receptors differently control synaptic plasticity in the mouse dorsal and ventral hippocampus Author(s): Sara L. Reis, Henrique B. Silva, Margarida Almeida, Rodrigo A. Cunha, Ana P. Simões, Paula M. Canas Published in: Journal of Neurochemistry, Issue 151/2, 2019, Page(s) 227-237, ISSN 0022-3042 Publisher: Blackwell Publishing Inc. DOI: 10.1111/jnc.14816 Estimates of Geriatric Delirium Frequency in Noncardiac Surgeries and Its Evaluation Across the Years: A Systematic Review and Meta-analysis Author(s): Ana Rita Silva, Patrícia Regueira, Elisabete Albuquerque, Inês Baldeiras, Ana Luísa Cardoso, Isabel Santana, Joaquim Cerejeira Published in: Journal of the American Medical Directors Association, 2020, ISSN 1525-8610 Publisher: Lippincott Williams & Wilkins Ltd. DOI: 10.1016/j.jamda.2020.08.017 Face-Specific Perceptual Distortions Reveal A View- and Orientation-Independent Face Template Author(s): Jorge Almeida, Andreia Freixo, Miguel Tábuas-Pereira, Sarah B. Herald, Daniela Valério, Guilherme Schu, Diana Duro, Gil Cunha, Qasim Bukhari, Brad Duchaine, Isabel Santana Published in: Current Biology, Issue 30/20, 2020, Page(s) 4071-4077.e4, ISSN 0960-9822 Publisher: Cell Press DOI: 10.1016/j.cub.2020.07.067 Synaptic and memory dysfunction in a β-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine Author(s): Francisco Q. Gonçalves, João P. Lopes, Henrique B. Silva, Cristina Lemos, António C. Silva, Nélio Gonçalves, Ângelo R. Tomé, Samira G. Ferreira, Paula M. Canas, Daniel Rial, Paula Agostinho, Rodrigo A. Cunha Published in: Neurobiology of Disease, Issue 132, 2019, Page(s) 104570, ISSN 0969-9961 Publisher: Academic Press DOI: 10.1016/j.nbd.2019.104570 A different vision of translational research in biomarker discovery: a pilot study on circulatory mitochondrial proteins as Parkinson’s disease potential biomarkers Author(s): Sandra I. Anjo, Patrícia Valério dos Santos, Luiza Rosado, Graça Baltazar, Inês Baldeiras, Diana Pires, Andreia Gomes, Cristina Januário, Miguel Castelo-Branco, Mário Grãos, Bruno Manadas Published in: Translational Neurodegeneration, Issue 9/1, 2020, ISSN 2047-9158 Publisher: BMC DOI: 10.1186/s40035-020-00188-0 Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality Author(s): Jonas Walter, Silvia Bolognin, Paul M.A. Antony, Sarah L. Nickels, Suresh K. Poovathingal, Luis Salamanca, Stefano Magni, Rita Perfeito, Fredrik Hoel, Xiaobing Qing, Javier Jarazo, Jonathan Arias-Fuenzalida, Tomasz Ignac, Anna S. Monzel, Laura Gonzalez-Cano, Luis Pereira de Almeida, Alexander Skupin, Karl J. Tronstad, Jens C. Schwamborn Published in: Stem Cell Reports, Issue 12/5, 2019, Page(s) 878-889, ISSN 2213-6711 Publisher: Cell Press DOI: 10.1016/j.stemcr.2019.03.004 In Silico Studies Targeting G-protein Coupled Receptors for Drug Research Against Parkinson’s Disease Author(s): Agostinho Lemos, Rita Melo, Antonio Jose Preto, Jose Guilherme Almeida, Irina Sousa Moreira, Maria Natalia Dias Soeiro Cordeiro Published in: Current Neuropharmacology, Issue 16/6, 2018, Page(s) 786-848, ISSN 1570-159X Publisher: Bentham Science Publishers DOI: 10.2174/1570159x16666180308161642 MiR-144 overexpression as a promising therapeutic strategy to overcome glioblastoma cell invasiveness and resistance to chemotherapy Author(s): Ana M S Cardoso, Madalena Sousa, Catarina M Morais, Liliana R Oancea-Castillo, Anne Régnier-Vigouroux, Olinda Rebelo, Hermínio Tão, Marcos Barbosa, Maria C de Lima Pedroso, Amália S Jurado Published in: Human Molecular Genetics, Issue 28/16, 2019, Page(s) 2738-2751, ISSN 0964-6906 Publisher: Oxford University Press DOI: 10.1093/hmg/ddz099 Region-specific control of microglia by adenosine A 2A receptors: uncoupling anxiety and associated cognitive deficits in female rats Author(s): Joana Mendes Duarte, Rita Gaspar, Liliana Caetano, Patrícia Patrício, Carina Soares-Cunha, António Mateus-Pinheiro, Nuno Dinis Alves, Ana Rita Santos, Samira G Ferreira, Vanessa Sardinha, João Filipe Oliveira, Carlos Fontes-Ribeiro, Nuno Sousa, Rodrigo A. Cunha, António F. Ambrósio, Luísa Pinto, Ana João Rodrigues, Catarina A. Gomes Published in: Glia, Issue 67/1, 2019, Page(s) 182-192, ISSN 0894-1491 Publisher: John Wiley & Sons Inc. DOI: 10.1002/glia.23476 Synaptogenesis Stimulates a Proteasome-Mediated Ribosome Reduction in Axons Author(s): Rui O. Costa, Helena Martins, Luís F. Martins, Andrzej W. Cwetsch, Miranda Mele, Joana R. Pedro, Diogo Tomé, Noo Li Jeon, Laura Cancedda, Samie R. Jaffrey, Ramiro D. Almeida Published in: Cell Reports, Issue 28/4, 2019, Page(s) 864-876.e6, ISSN 2211-1247 Publisher: Cell Press DOI: 10.1016/j.celrep.2019.06.080 QbD-driven development of intranasal lipid nanoparticles for depression treatment Author(s): Carla Vitorino, Soraia Silva, Filipa Gouveia, Joana Bicker, Amílcar Falcão, Ana Fortuna Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue 153, 2020, Page(s) 106-120, ISSN 0939-6411 Publisher: Elsevier BV DOI: 10.1016/j.ejpb.2020.04.011 Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases Author(s): Ana Luisa Cardoso, Adelaide Fernandes, Juan Antonio Aguilar-Pimentel, Martin Hrabě de Angelis, Joana Ribeiro Guedes, Maria Alexandra Brito, Saida Ortolano, Giovambattista Pani, Sophia Athanasopoulou, Efstathios S. Gonos, Markus Schosserer, Johannes Grillari, Pärt Peterson, Bilge Guvenc Tuna, Soner Dogan, Angelika Meyer, Ronald van Os, Anne-Ulrike Trendelenburg Published in: Ageing Research Reviews, Issue 47, 2018, Page(s) 214-277, ISSN 1568-1637 Publisher: Elsevier BV DOI: 10.1016/j.arr.2018.07.004 Machado-Joseph disease/spinocerebellar ataxia type 3: lessons from disease pathogenesis and clues into therapy Author(s): Carlos A. Matos, Luís Pereira de Almeida, Clévio Nóbrega Published in: Journal of Neurochemistry, Issue 148/1, 2019, Page(s) 8-28, ISSN 0022-3042 Publisher: Blackwell Publishing Inc. DOI: 10.1111/jnc.14541 Sweet Mitochondria: A Shortcut to Alzheimer’s Disease Author(s): Paula I. Moreira Published in: Journal of Alzheimer's Disease, Issue 62/3, 2018, Page(s) 1391-1401, ISSN 1387-2877 Publisher: IOS Press DOI: 10.3233/jad-170931 What is the extracellular calcium concentration within brain synapses? Author(s): João Pedro Lopes, Rodrigo A. Cunha Published in: Journal of Neurochemistry, Issue 149/4, 2019, Page(s) 435-437, ISSN 0022-3042 Publisher: Blackwell Publishing Inc. DOI: 10.1111/jnc.14696 Retinal thinning of inner sub-layers is associated with cortical atrophy in a mouse model of Alzheimer’s disease: a longitudinal multimodal in vivo study Author(s): Samuel Chiquita, Elisa J. Campos, João Castelhano, Mário Ribeiro, José Sereno, Paula I. Moreira, Miguel Castelo-Branco, António Francisco Ambrósio Published in: Alzheimer's Research & Therapy, Issue 11/1, 2019, ISSN 1758-9193 Publisher: BioMed Central DOI: 10.1186/s13195-019-0542-8 Cerebrospinal fluid neurofilament light levels in neurodegenerative dementia: Evaluation of diagnostic accuracy in the differential diagnosis of prion diseases Author(s): Inga Zerr, Matthias Schmitz, André Karch, Anna Villar-Piqué, Eirini Kanata, Ewa Golanska, Daniela Díaz-Lucena, Aikaterini Karsanidou, Peter Hermann, Tobias Knipper, Stefan Goebel, Daniela Varges, Theodoros Sklaviadis, Beata Sikorska, Pawel P. Liberski, Isabel Santana, Isidro Ferrer, Henrik Zetterberg, Kaj Blennow, Olga Calero, Miguel Calero, Anna Ladogana, Raquel Sánchez-Valle, Inês Baldeiras Published in: Alzheimer's & Dementia, Issue 14/6, 2018, Page(s) 751-763, ISSN 1552-5260 Publisher: Elsevier BV DOI: 10.1016/j.jalz.2017.12.008 A whole brain longitudinal study in the YAC128 mouse model of Huntington’s disease shows distinct trajectories of neurochemical, structural connectivity and volumetric changes Author(s): Lorena I Petrella, João M Castelhano, Mario Ribeiro, José V Sereno, Sónia I Gonçalves, Mário N Laço, Michael R Hayden, A Cristina Rego, Miguel Castelo-Branco Published in: Human Molecular Genetics, Issue 27/12, 2018, Page(s) 2125-2137, ISSN 0964-6906 Publisher: Oxford University Press DOI: 10.1093/hmg/ddy119 Cordycepin activates autophagy through AMPK phosphorylation to reduce abnormalities in Machado–Joseph disease models Author(s): Adriana Marcelo, Filipa Brito, Sara Carmo-Silva, Carlos A Matos, João Alves-Cruzeiro, Ana Vasconcelos-Ferreira, Rebekah Koppenol, Liliana Mendonça, Luís Pereira de Almeida, Clévio Nóbrega Published in: Human Molecular Genetics, Issue 28/1, 2018, Page(s) 51-63, ISSN 0964-6906 Publisher: Oxford University Press DOI: 10.1093/hmg/ddy328 Control of glutamate release by complexes of adenosine and cannabinoid receptors Author(s): Attila Köfalvi, Estefanía Moreno, Arnau Cordomí, Ning-Sheng Cai, Victor Fernández-Dueñas, Samira G. Ferreira, Ramón Guixà-González, Marta Sánchez-Soto, Hideaki Yano, Verònica Casadó-Anguera, Rodrigo A. Cunha, Ana Maria Sebastião, Francisco Ciruela, Leonardo Pardo, Vicent Casadó, Sergi Ferré Published in: BMC Biology, Issue 18/1, 2020, ISSN 1741-7007 Publisher: BioMed Central DOI: 10.1186/s12915-020-0739-0 Recurrent Stroke With Rivaroxaban Compared With Aspirin According to Predictors of Atrial Fibrillation Author(s): Jeff S. Healey, David J. Gladstone, Balakumar Swaminathan, Jens Eckstein, Hardi Mundl, Andrew E. Epstein, Karl Georg Haeusler, Robert Mikulik, Scott E. Kasner, Danilo Toni, Antonio Arauz, George Ntaios, Graeme J. Hankey, Kanjana Perera, Jorge Pagola, Ashfaq Shuaib, Helmi Lutsep, Xiaomeng Yang, Shinichiro Uchiyama, Matthias Endres, Shelagh B. Coutts, Michal Karlinski, Anna Czlonkowska, Carlos A. Mo Published in: JAMA Neurology, Issue 76/7, 2019, Page(s) 764, ISSN 2168-6149 Publisher: American Medical Association DOI: 10.1001/jamaneurol.2019.0617 Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease Author(s): Niklas Mattsson, Colin Groot, Willemijn J. Jansen, Susan M. Landau, Victor L. Villemagne, Sebastiaan Engelborghs, Mark M. Mintun, Alberto Lleo, José Luis Molinuevo, William J. Jagust, Giovanni B. Frisoni, Adrian Ivanoiu, Gaël Chételat, Catarina Resende de Oliveira, Karen M. Rodrigue, Johannes Kornhuber, Anders Wallin, Aleksandra Klimkowicz-Mrowiec, Ramesh Kandimalla, Julius Popp, Pauline P. Aal Published in: Alzheimer's & Dementia, Issue 14/7, 2018, Page(s) 913-924, ISSN 1552-5260 Publisher: Elsevier BV DOI: 10.1016/j.jalz.2018.02.009 Erlangen Score as a tool to predict progression from mild cognitive impairment to dementia in Alzheimer’s disease Author(s): Inês Baldeiras, Isabel Santana, Maria João Leitão, Daniela Vieira, Diana Duro, Barbara Mroczko, Johannes Kornhuber, Piotr Lewczuk Published in: Alzheimer's Research & Therapy, Issue 11/1, 2019, ISSN 1758-9193 Publisher: BioMed Central DOI: 10.1186/s13195-018-0456-x Chronic hyperglycemia impairs hippocampal neurogenesis and memory in an Alzheimer’s disease mouse model Author(s): Elisabete Ferreiro, Mariagrazia Lanzillo, Diogo Canhoto, António M. Carvalho da Silva, Sandra I. Mota, Inês S. Dias, Ildete L. Ferreira, Ana R. Fontes, Giorgia Mastrella, Paulo Pinheiro, Jorge Valero, A. Cristina Rego Published in: Neurobiology of Aging, Issue 92, 2020, Page(s) 98-113, ISSN 0197-4580 Publisher: Elsevier BV DOI: 10.1016/j.neurobiolaging.2020.04.003 Addition of the Aβ42/40 ratio to the cerebrospinal fluid biomarker profile increases the predictive value for underlying Alzheimer’s disease dementia in mild cognitive impairment Author(s): Inês Baldeiras, Isabel Santana, Maria João Leitão, Helena Gens, Rui Pascoal, Miguel Tábuas-Pereira, José Beato-Coelho, Diana Duro, Maria Rosário Almeida, Catarina Resende Oliveira Published in: Alzheimer's Research & Therapy, Issue 10/1, 2018, ISSN 1758-9193 Publisher: BioMed Central DOI: 10.1186/s13195-018-0362-2 Shaping the Nrf2-ARE-related pathways in Alzheimer’s and Parkinson’s diseases Author(s): Lígia Fão, Sandra I. Mota, A. Cristina Rego Published in: Ageing Research Reviews, Issue 54, 2019, Page(s) 100942, ISSN 1568-1637 Publisher: Elsevier BV DOI: 10.1016/j.arr.2019.100942 Mitochondrial and Redox-Based Therapeutic Strategies in Huntington's Disease Author(s): Lígia Fão, Ana Cristina Rego Published in: Antioxidants & Redox Signaling, Issue 34/8, 2021, Page(s) 650-673, ISSN 1523-0864 Publisher: Mary Ann Liebert Inc. DOI: 10.1089/ars.2019.8004 mtDNA copy number associated with age of onset in familial amyloid polyneuropathy Author(s): Diana Santos, Maria João Santos, Miguel Alves-Ferreira, Teresa Coelho, Jorge Sequeiros, Isabel Alonso, Pedro Oliveira, Alda Sousa, Carolina Lemos, Manuela Grazina Published in: Journal of Neurology, Neurosurgery & Psychiatry, Issue 89/3, 2018, Page(s) 300-304, ISSN 0022-3050 Publisher: BMJ Publishing Group DOI: 10.1136/jnnp-2017-316657 Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia Author(s): Franc Llorens, Peter Hermann, Anna Villar-Piqué, Daniela Diaz-Lucena, Katarina Nägga, Oskar Hansson, Isabel Santana, Matthias Schmitz, Christian Schmidt, Daniela Varges, Stefan Goebel, Julien Dumurgier, Henrik Zetterberg, Kaj Blennow, Claire Paquet, Inês Baldeiras, Isidro Ferrer, Inga Zerr Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-020-14373-2 Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer’s disease features in cortical neurons Author(s): Diana F. Silva, Emanuel Candeias, A. Raquel Esteves, João D. Magalhães, I. Luísa Ferreira, Daniela Nunes-Costa, A. Cristina Rego, Nuno Empadinhas, Sandra M. Cardoso Published in: Journal of Neuroinflammation, Issue 17/1, 2020, ISSN 1742-2094 Publisher: BioMed Central DOI: 10.1186/s12974-020-02004-y Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease Author(s): Catarina Oliveira Miranda, Adriana Marcelo, Teresa Pereira Silva, João Barata, Ana Vasconcelos-Ferreira, Dina Pereira, Clévio Nóbrega, Sónia Duarte, Inês Barros, Joana Alves, José Sereno, Lorena Itatí Petrella, João Castelhano, Vitor Hugo Paiva, Paulo Rodrigues-Santos, Vera Alves, Isabel Nunes-Correia, Rui Jorge Nobre, Célia Gomes, Miguel Castelo-Branco, Luís Pereira de Almeida Published in: Molecular Therapy, Issue 26/9, 2018, Page(s) 2131-2151, ISSN 1525-0016 Publisher: Nature Publishing Group DOI: 10.1016/j.ymthe.2018.07.007 Distinct subnetworks of the thalamic reticular nucleus Author(s): Yinqing Li, Violeta G. Lopez-Huerta, Xian Adiconis, Kirsten Levandowski, Soonwook Choi, Sean K. Simmons, Mario A. Arias-Garcia, Baolin Guo, Annie Y. Yao, Timothy R. Blosser, Ralf D. Wimmer, Tomomi Aida, Alexander Atamian, Tina Naik, Xuyun Sun, Dasheng Bi, Diya Malhotra, Cynthia C. Hession, Reut Shema, Marcos Gomes, Taibo Li, Eunjin Hwang, Alexandra Krol, Monika Kowalczyk, João Peça, Gang Pan, Mi Published in: Nature, Issue 583/7818, 2020, Page(s) 819-824, ISSN 0028-0836 Publisher: Nature Publishing Group DOI: 10.1038/s41586-020-2504-5 Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
