DYNAMIC BRAIN FUNCTION: Towards the Understanding and Treatment of Brain Disorders

Deliverables

Dissemination of ERA Chair holder position

Dissemination of ERA Chair holder position including social media channels

Publication of the ERA Chair position announcement

Publication of the ERA Chair position announcement EURAXESS reference scientific journals

Webpage of the project

Data Management Plan

Publication of the Initial Data Management Plan

Research QA Handbook
D&C and Exploitation plan
Laboratory fully operational

ERA Chair laboratory fully operational (including purchase of equipment)

Detailed outline of the International Doctoral Programme in Neuroscience

Detailed outline for the International Doctoral Programme in Neuroscience

Publications

The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples

Author(s): Diana Duarte Lobo, Rui Jorge Nobre, Catarina Oliveira Miranda, Dina Pereira, João Castelhano, José Sereno, Arnulf Koeppen, Miguel Castelo-Branco, Luís Pereira de Almeida
Published in: Acta Neuropathologica Communications, Issue 8/1, 2020, ISSN 2051-5960
Publisher: BioMed Central
DOI: 10.1186/s40478-020-00955-0

Adenosine A2A receptors format long-term depression and memory strategies in a mouse model of Angelman syndrome

Author(s): Ana Moreira-de-Sá, Francisco Q. Gonçalves, João P. Lopes, Henrique B. Silva, Ângelo R. Tomé, Rodrigo A. Cunha, Paula M. Canas
Published in: Neurobiology of Disease, Issue 146, 2020, Page(s) 105137, ISSN 0969-9961
Publisher: Academic Press
DOI: 10.1016/j.nbd.2020.105137

Meningeal γδ T cell–derived IL-17 controls synaptic plasticity and short-term memory

Author(s): Miguel Ribeiro, Helena C. Brigas, Mariana Temido-Ferreira, Paula A. Pousinha, Tommy Regen, Cátia Santa, Joana E. Coelho, Inês Marques-Morgado, Cláudia A. Valente, Sara Omenetti, Brigitta Stockinger, Ari Waisman, Bruno Manadas, Luísa V. Lopes, Bruno Silva-Santos, Julie C. Ribot
Published in: Science Immunology, Issue 4/40, 2019, Page(s) eaay5199, ISSN 2470-9468
Publisher: AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciimmunol.aay5199

Signaling by adenosine receptors—Homeostatic or allostatic control?

Author(s): Rodrigo A. Cunha
Published in: PLOS Biology, Issue 17/4, 2019, Page(s) e3000213, ISSN 1545-7885
Publisher: PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pbio.3000213

Disrupted AMPA Receptor Function upon Genetic- or Antibody-Mediated Loss of Autism-Associated CASPR2

Author(s): Dominique Fernandes, Sandra D Santos, Ester Coutinho, Jessica L Whitt, Nuno Beltrão, Tiago Rondão, M Isabel Leite, Camilla Buckley, Hey-Kyoung Lee, Ana Luísa Carvalho
Published in: Cerebral Cortex, Issue 29/12, 2019, Page(s) 4919-4931, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhz032

Diabetes–Alzheimer's Disease Link: Targeting Mitochondrial Dysfunction and Redox Imbalance

Author(s): Cristina Carvalho, Susana Cardoso
Published in: Antioxidants & Redox Signaling, 2020, ISSN 1523-0864
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/ars.2020.8056

BDNF increases synaptic NMDA receptor abundance by enhancing the local translation of Pyk2 in cultured hippocampal neurons

Author(s): Pedro Afonso, Pasqualino De Luca, Rafael S. Carvalho, Luísa Cortes, Paulo Pinheiro, Barbara Oliveiros, Ramiro D. Almeida, Miranda Mele, Carlos B. Duarte
Published in: Science Signaling, Issue 12/586, 2019, Page(s) eaav3577, ISSN 1937-9145
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scisignal.aav3577

A longitudinal multimodal in vivo molecular imaging study of the 3xTg-AD mouse model shows progressive early hippocampal and taurine loss

Author(s): Samuel Chiquita, Mário Ribeiro, João Castelhano, Francisco Oliveira, José Sereno, Marta Batista, Antero Abrunhosa, Ana C Rodrigues-Neves, Rafael Carecho, Filipa Baptista, Catarina Gomes, Paula I Moreira, António F Ambrósio, Miguel Castelo-Branco
Published in: Human Molecular Genetics, Issue 28/13, 2019, Page(s) 2174-2188, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddz045

Enhanced ATP release and CD73‐mediated adenosine formation sustain adenosine A 2A receptor over‐activation in a rat model of Parkinson's disease

Author(s): Marta Carmo, Francisco Q. Gonçalves, Paula M. Canas, Jean‐Pierre Oses, Francisco D. Fernandes, Filipe V. Duarte, Carlos M. Palmeira, Angelo R. Tomé, Paula Agostinho, Geanne M. Andrade, Rodrigo A. Cunha
Published in: British Journal of Pharmacology, Issue 176/18, 2019, Page(s) 3666-3680, ISSN 0007-1188
Publisher: Wiley-Blackwell
DOI: 10.1111/bph.14771

Transcriptional consequences of MBD5 disruption in mouse brain and CRISPR-derived neurons

Author(s): Catarina M. Seabra, Tatsiana Aneichyk, Serkan Erdin, Derek J. C. Tai, Celine E. F. De Esch, Parisa Razaz, Yu An, Poornima Manavalan, Ashok Ragavendran, Alexei Stortchevoi, Clemer Abad, Juan I. Young, Patricia Maciel, Michael E. Talkowski, James F. Gusella
Published in: Molecular Autism, Issue 11/1, 2020, ISSN 2040-2392
Publisher: BioMed Central
DOI: 10.1186/s13229-020-00354-1

Neuronal adenosine A2A receptors signal ergogenic effects of caffeine

Author(s): Aderbal S. Aguiar, Ana Elisa Speck, Paula M. Canas, Rodrigo A. Cunha
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-69660-1

Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice

Author(s): Mohamed Edfawy, Joana R. Guedes, Marta I. Pereira, Mariana Laranjo, Mário J. Carvalho, Xian Gao, Pedro A. Ferreira, Gladys Caldeira, Lara O. Franco, Dongqing Wang, Ana Luisa Cardoso, Guoping Feng, Ana Luisa Carvalho, João Peça
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-09382-9

Neurofilaments in spinocerebellar ataxia type 3: blood biomarkers at the preataxic and ataxic stage in humans and mice

Author(s): Carlo Wilke, Eva Haas, Kathrin Reetz, Jennifer Faber, Hector Garcia‐Moreno, Magda M Santana, Bart Warrenburg, Holger Hengel, Manuela Lima, Alessandro Filla, Alexandra Durr, Bela Melegh, Marcella Masciullo, Jon Infante, Paola Giunti, Manuela Neumann, Jeroen Vries, Luis Pereira de Almeida, Maria Rakowicz, Heike Jacobi, Rebecca Schüle, Stephan A Kaeser, Jens Kuhle, Thomas Klockgether, Ludger Schö
Published in: EMBO Molecular Medicine, Issue 12/7, 2020, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201911803

Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia

Author(s): Clévio Nóbrega, Liliana Mendonça, Adriana Marcelo, Antonin Lamazière, Sandra Tomé, Gaetan Despres, Carlos A. Matos, Fatich Mechmet, Dominique Langui, Wilfred den Dunnen, Luis Pereira de Almeida, Nathalie Cartier, Sandro Alves
Published in: Acta Neuropathologica, Issue 138/5, 2019, Page(s) 837-858, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-019-02019-7

Differential protein expression in diverse brain areas of Parkinson’s and Alzheimer’s disease patients

Author(s): A. R. Esteves, S. M. Cardoso
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-70174-z

A nanoformulation for the preferential accumulation in adult neurogenic niches

Author(s): Catarina Praça, Akhilesh Rai, Tiago Santos, Ana C. Cristovão, Sonia L. Pinho, Romeo Cecchelli, Marie-Pierre Dehouck, Liliana Bernardino, Lino S. Ferreira
Published in: Journal of Controlled Release, Issue 284, 2018, Page(s) 57-72, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2018.06.013

Author(s): Mariana Temido-Ferreira, Diana G. Ferreira, Vânia L. Batalha, Inês Marques-Morgado, Joana E. Coelho, Pedro Pereira, Rui Gomes, Andreia Pinto, Sara Carvalho, Paula M. Canas, Laetitia Cuvelier, Valerie Buée-Scherrer, Emilie Faivre, Younis Baqi, Christa E. Müller, José Pimentel, Serge N. Schiffmann, Luc Buée, Michael Bader, Tiago F. Outeiro, David Blum, Rodrigo A. Cunha, Hélène Marie, Paula A
Published in: Molecular Psychiatry, Issue 25/8, 2020, Page(s) 1876-1900, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-018-0110-9

MicroRNA-186-5p controls GluA2 surface expression and synaptic scaling in hippocampal neurons

Author(s): Mariline M. Silva, Beatriz Rodrigues, Joana Fernandes, Sandra D. Santos, Laura Carreto, Manuel A. S. Santos, Paulo Pinheiro, Ana Luísa Carvalho
Published in: Proceedings of the National Academy of Sciences, Issue 116/12, 2019, Page(s) 5727-5736, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1900338116

The importance of determining circadian parameters in pharmacological studies

Author(s): Laetitia S. Gaspar, Ana Rita Álvaro, Sara Carmo‐Silva, Alexandrina Ferreira Mendes, Angela Relógio, Cláudia Cavadas
Published in: British Journal of Pharmacology, Issue 176/16, 2019, Page(s) 2827-2847, ISSN 0007-1188
Publisher: Wiley-Blackwell
DOI: 10.1111/bph.14712

Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study

Author(s): Rita Guerreiro, Owen A Ross, Celia Kun-Rodrigues, Dena G Hernandez, Tatiana Orme, John D Eicher, Claire E Shepherd, Laura Parkkinen, Lee Darwent, Michael G Heckman, Sonja W Scholz, Juan C Troncoso, Olga Pletnikova, Olaf Ansorge, Jordi Clarimon, Alberto Lleo, Estrella Morenas-Rodriguez, Lorraine Clark, Lawrence S Honig, Karen Marder, Afina Lemstra, Ekaterina Rogaeva, Peter St George-Hyslop, Elisabe
Published in: The Lancet Neurology, Issue 17/1, 2018, Page(s) 64-74, ISSN 1474-4422
Publisher: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(17)30400-3

Derivation of Brain Capillary-like Endothelial Cells from Human Pluripotent Stem Cell-Derived Endothelial Progenitor Cells

Author(s): Catarina Praça, Susana C. Rosa, Emmanuel Sevin, Romeo Cecchelli, Marie-Pierre Dehouck, Lino S. Ferreira
Published in: Stem Cell Reports, Issue 13/4, 2019, Page(s) 599-611, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2019.08.002

Clinical validation of the Lumipulse G cerebrospinal fluid assays for routine diagnosis of Alzheimer’s disease

Author(s): Maria João Leitão, Anuschka Silva-Spínola, Isabel Santana, Veronica Olmedo, Alicia Nadal, Nathalie Le Bastard, Inês Baldeiras
Published in: Alzheimer's Research & Therapy, Issue 11/1, 2019, ISSN 1758-9193
Publisher: BioMed Central
DOI: 10.1186/s13195-019-0550-8

Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study

Author(s): Katrina M Moore, Jennifer Nicholas, Murray Grossman, Corey T McMillan, David J Irwin, Lauren Massimo, Vivianna M Van Deerlin, Jason D Warren, Nick C Fox, Martin N Rossor, Simon Mead, Martina Bocchetta, Bradley F Boeve, David S Knopman, Neill R Graff-Radford, Leah K Forsberg, Rosa Rademakers, Zbigniew K Wszolek, John C van Swieten, Lize C Jiskoot, Lieke H Meeter, Elise GP Dopper, Janne M Papma, Jul
Published in: The Lancet Neurology, Issue 19/2, 2020, Page(s) 145-156, ISSN 1474-4422
Publisher: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(19)30394-1

Enhanced selectivity and stability of ruthenium purple-modified carbon fiber microelectrodes for detection of hydrogen peroxide in brain tissue

Author(s): Ana Ledo, Eliana Fernandes, Christopher M.A. Brett, Rui M. Barbosa
Published in: Sensors and Actuators B: Chemical, Issue 311, 2020, Page(s) 127899, ISSN 0925-4005
Publisher: Elsevier BV
DOI: 10.1016/j.snb.2020.127899

Differential Nanoscale Topography and Functional Role of GluN2-NMDA Receptor Subtypes at Glutamatergic Synapses

Author(s): Blanka Kellermayer, Joana S. Ferreira, Julien Dupuis, Florian Levet, Dolors Grillo-Bosch, Lucie Bard, Jeanne Linarès-Loyez, Delphine Bouchet, Daniel Choquet, Dmitri A. Rusakov, Pierre Bon, Jean-Baptiste Sibarita, Laurent Cognet, Matthieu Sainlos, Ana Luisa Carvalho, Laurent Groc
Published in: Neuron, Issue 100/1, 2018, Page(s) 106-119.e7, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2018.09.012

Dichotomous Sirtuins: Implications for Drug Discovery in Neurodegenerative and Cardiometabolic Diseases

Author(s): Pedro Gomes, Helena Leal, Alexandrina F. Mendes, Flávio Reis, Cláudia Cavadas
Published in: Trends in Pharmacological Sciences, Issue 40/12, 2019, Page(s) 1021-1039, ISSN 0165-6147
Publisher: Elsevier BV
DOI: 10.1016/j.tips.2019.09.003

Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial

Author(s): Scott E Kasner, Balakumar Swaminathan, Pablo Lavados, Mukul Sharma, Keith Muir, Roland Veltkamp, Sebastian F Ameriso, Matthias Endres, Helmi Lutsep, Steven R Messé, J David Spence, Krassen Nedeltechev, Kanjana Perera, Gustavo Santo, Veronica Olavarria, Arne Lindgren, Shrikant Bangdiwala, Ashkan Shoamanesh, Scott D Berkowitz, Hardi Mundl, Stuart J Connolly, Robert G Hart, N Abdelhamid, D Abdul Rah
Published in: The Lancet Neurology, Issue 17/12, 2018, Page(s) 1053-1060, ISSN 1474-4422
Publisher: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(18)30319-3

Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells

Author(s): Célia A Aveleira, Marisa Ferreira-Marques, Luísa Cortes, Jorge Valero, Dina Pereira, Luís Pereira de Almeida, Cláudia Cavadas
Published in: The Journals of Gerontology: Series A, Issue 75/6, 2020, Page(s) 1073-1078, ISSN 1079-5006
Publisher: Gerontological Society of America
DOI: 10.1093/gerona/glz280

Overactivity of neuronal adenosine A2A receptors accelerates neurodegeneration

Author(s): Rodrigo A Cunha
Published in: Brain, Issue 142/11, 2019, Page(s) 3323-3324, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awz335

Dual Therapy with Liraglutide and Ghrelin Promotes Brain and Peripheral Energy Metabolism in the R6/2 Mouse Model of Huntington’s Disease

Author(s): Ana I. Duarte, Marie Sjögren, Maria S. Santos, Catarina R. Oliveira, Paula I. Moreira, Maria Björkqvist
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-27121-w

Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury

Author(s): Elisa M. Floriddia, Tânia Lourenço, Shupei Zhang, David van Bruggen, Markus M. Hilscher, Petra Kukanja, João P. Gonçalves dos Santos, Müge Altınkök, Chika Yokota, Enric Llorens-Bobadilla, Sara B. Mulinyawe, Mário Grãos, Lu O. Sun, Jonas Frisén, Mats Nilsson, Gonçalo Castelo-Branco
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-19453-x

Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin

Author(s): Sindhuja Gowrisankaran, Sébastien Houy, Johanna G. Peña del Castillo, Vicky Steubler, Monika Gelker, Jana Kroll, Paulo S. Pinheiro, Dirk Schwitters, Nils Halbsgut, Arndt Pechstein, Jan R. T. van Weering, Tanja Maritzen, Volker Haucke, Nuno Raimundo, Jakob B. Sørensen, Ira Milosevic
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-14993-8

Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia

Author(s): Willemijn J. Jansen, Rik Ossenkoppele, Betty M. Tijms, Anne M. Fagan, Oskar Hansson, William E. Klunk, Wiesje M. van der Flier, Victor L. Villemagne, Giovanni B. Frisoni, Adam S. Fleisher, Alberto Lleó, Mark A. Mintun, Anders Wallin, Sebastiaan Engelborghs, Duk L. Na, Gäel Chételat, José Luis Molinuevo, Susan M. Landau, Niklas Mattsson, Johannes Kornhuber, Osama Sabri, Christopher C. Rowe, Luc
Published in: JAMA Psychiatry, Issue 75/1, 2018, Page(s) 84, ISSN 2168-622X
Publisher: American Medical Association
DOI: 10.1001/jamapsychiatry.2017.3391

Adenosine A 1 and A 2A receptors differently control synaptic plasticity in the mouse dorsal and ventral hippocampus

Author(s): Sara L. Reis, Henrique B. Silva, Margarida Almeida, Rodrigo A. Cunha, Ana P. Simões, Paula M. Canas
Published in: Journal of Neurochemistry, Issue 151/2, 2019, Page(s) 227-237, ISSN 0022-3042
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jnc.14816

Estimates of Geriatric Delirium Frequency in Noncardiac Surgeries and Its Evaluation Across the Years: A Systematic Review and Meta-analysis

Author(s): Ana Rita Silva, Patrícia Regueira, Elisabete Albuquerque, Inês Baldeiras, Ana Luísa Cardoso, Isabel Santana, Joaquim Cerejeira
Published in: Journal of the American Medical Directors Association, 2020, ISSN 1525-8610
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1016/j.jamda.2020.08.017

Face-Specific Perceptual Distortions Reveal A View- and Orientation-Independent Face Template

Author(s): Jorge Almeida, Andreia Freixo, Miguel Tábuas-Pereira, Sarah B. Herald, Daniela Valério, Guilherme Schu, Diana Duro, Gil Cunha, Qasim Bukhari, Brad Duchaine, Isabel Santana
Published in: Current Biology, Issue 30/20, 2020, Page(s) 4071-4077.e4, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2020.07.067

Synaptic and memory dysfunction in a β-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine

Author(s): Francisco Q. Gonçalves, João P. Lopes, Henrique B. Silva, Cristina Lemos, António C. Silva, Nélio Gonçalves, Ângelo R. Tomé, Samira G. Ferreira, Paula M. Canas, Daniel Rial, Paula Agostinho, Rodrigo A. Cunha
Published in: Neurobiology of Disease, Issue 132, 2019, Page(s) 104570, ISSN 0969-9961
Publisher: Academic Press
DOI: 10.1016/j.nbd.2019.104570

A different vision of translational research in biomarker discovery: a pilot study on circulatory mitochondrial proteins as Parkinson’s disease potential biomarkers

Author(s): Sandra I. Anjo, Patrícia Valério dos Santos, Luiza Rosado, Graça Baltazar, Inês Baldeiras, Diana Pires, Andreia Gomes, Cristina Januário, Miguel Castelo-Branco, Mário Grãos, Bruno Manadas
Published in: Translational Neurodegeneration, Issue 9/1, 2020, ISSN 2047-9158
Publisher: BMC
DOI: 10.1186/s40035-020-00188-0

Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality

Author(s): Jonas Walter, Silvia Bolognin, Paul M.A. Antony, Sarah L. Nickels, Suresh K. Poovathingal, Luis Salamanca, Stefano Magni, Rita Perfeito, Fredrik Hoel, Xiaobing Qing, Javier Jarazo, Jonathan Arias-Fuenzalida, Tomasz Ignac, Anna S. Monzel, Laura Gonzalez-Cano, Luis Pereira de Almeida, Alexander Skupin, Karl J. Tronstad, Jens C. Schwamborn
Published in: Stem Cell Reports, Issue 12/5, 2019, Page(s) 878-889, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2019.03.004

In Silico Studies Targeting G-protein Coupled Receptors for Drug Research Against Parkinson’s Disease

Author(s): Agostinho Lemos, Rita Melo, Antonio Jose Preto, Jose Guilherme Almeida, Irina Sousa Moreira, Maria Natalia Dias Soeiro Cordeiro
Published in: Current Neuropharmacology, Issue 16/6, 2018, Page(s) 786-848, ISSN 1570-159X
Publisher: Bentham Science Publishers
DOI: 10.2174/1570159x16666180308161642

MiR-144 overexpression as a promising therapeutic strategy to overcome glioblastoma cell invasiveness and resistance to chemotherapy

Author(s): Ana M S Cardoso, Madalena Sousa, Catarina M Morais, Liliana R Oancea-Castillo, Anne Régnier-Vigouroux, Olinda Rebelo, Hermínio Tão, Marcos Barbosa, Maria C de Lima Pedroso, Amália S Jurado
Published in: Human Molecular Genetics, Issue 28/16, 2019, Page(s) 2738-2751, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddz099

Region-specific control of microglia by adenosine A 2A receptors: uncoupling anxiety and associated cognitive deficits in female rats

Author(s): Joana Mendes Duarte, Rita Gaspar, Liliana Caetano, Patrícia Patrício, Carina Soares-Cunha, António Mateus-Pinheiro, Nuno Dinis Alves, Ana Rita Santos, Samira G Ferreira, Vanessa Sardinha, João Filipe Oliveira, Carlos Fontes-Ribeiro, Nuno Sousa, Rodrigo A. Cunha, António F. Ambrósio, Luísa Pinto, Ana João Rodrigues, Catarina A. Gomes
Published in: Glia, Issue 67/1, 2019, Page(s) 182-192, ISSN 0894-1491
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/glia.23476

Synaptogenesis Stimulates a Proteasome-Mediated Ribosome Reduction in Axons

Author(s): Rui O. Costa, Helena Martins, Luís F. Martins, Andrzej W. Cwetsch, Miranda Mele, Joana R. Pedro, Diogo Tomé, Noo Li Jeon, Laura Cancedda, Samie R. Jaffrey, Ramiro D. Almeida
Published in: Cell Reports, Issue 28/4, 2019, Page(s) 864-876.e6, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.06.080

QbD-driven development of intranasal lipid nanoparticles for depression treatment

Author(s): Carla Vitorino, Soraia Silva, Filipa Gouveia, Joana Bicker, Amílcar Falcão, Ana Fortuna
Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue 153, 2020, Page(s) 106-120, ISSN 0939-6411
Publisher: Elsevier BV
DOI: 10.1016/j.ejpb.2020.04.011

Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases

Author(s): Ana Luisa Cardoso, Adelaide Fernandes, Juan Antonio Aguilar-Pimentel, Martin Hrabě de Angelis, Joana Ribeiro Guedes, Maria Alexandra Brito, Saida Ortolano, Giovambattista Pani, Sophia Athanasopoulou, Efstathios S. Gonos, Markus Schosserer, Johannes Grillari, Pärt Peterson, Bilge Guvenc Tuna, Soner Dogan, Angelika Meyer, Ronald van Os, Anne-Ulrike Trendelenburg
Published in: Ageing Research Reviews, Issue 47, 2018, Page(s) 214-277, ISSN 1568-1637
Publisher: Elsevier BV
DOI: 10.1016/j.arr.2018.07.004

Machado-Joseph disease/spinocerebellar ataxia type 3: lessons from disease pathogenesis and clues into therapy

Author(s): Carlos A. Matos, Luís Pereira de Almeida, Clévio Nóbrega
Published in: Journal of Neurochemistry, Issue 148/1, 2019, Page(s) 8-28, ISSN 0022-3042
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jnc.14541

Sweet Mitochondria: A Shortcut to Alzheimer’s Disease

Author(s): Paula I. Moreira
Published in: Journal of Alzheimer's Disease, Issue 62/3, 2018, Page(s) 1391-1401, ISSN 1387-2877
Publisher: IOS Press
DOI: 10.3233/jad-170931

What is the extracellular calcium concentration within brain synapses?

Author(s): João Pedro Lopes, Rodrigo A. Cunha
Published in: Journal of Neurochemistry, Issue 149/4, 2019, Page(s) 435-437, ISSN 0022-3042
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jnc.14696

Retinal thinning of inner sub-layers is associated with cortical atrophy in a mouse model of Alzheimer’s disease: a longitudinal multimodal in vivo study

Author(s): Samuel Chiquita, Elisa J. Campos, João Castelhano, Mário Ribeiro, José Sereno, Paula I. Moreira, Miguel Castelo-Branco, António Francisco Ambrósio
Published in: Alzheimer's Research & Therapy, Issue 11/1, 2019, ISSN 1758-9193
Publisher: BioMed Central
DOI: 10.1186/s13195-019-0542-8

Cerebrospinal fluid neurofilament light levels in neurodegenerative dementia: Evaluation of diagnostic accuracy in the differential diagnosis of prion diseases

Author(s): Inga Zerr, Matthias Schmitz, André Karch, Anna Villar-Piqué, Eirini Kanata, Ewa Golanska, Daniela Díaz-Lucena, Aikaterini Karsanidou, Peter Hermann, Tobias Knipper, Stefan Goebel, Daniela Varges, Theodoros Sklaviadis, Beata Sikorska, Pawel P. Liberski, Isabel Santana, Isidro Ferrer, Henrik Zetterberg, Kaj Blennow, Olga Calero, Miguel Calero, Anna Ladogana, Raquel Sánchez-Valle, Inês Baldeiras
Published in: Alzheimer's & Dementia, Issue 14/6, 2018, Page(s) 751-763, ISSN 1552-5260
Publisher: Elsevier BV
DOI: 10.1016/j.jalz.2017.12.008

A whole brain longitudinal study in the YAC128 mouse model of Huntington’s disease shows distinct trajectories of neurochemical, structural connectivity and volumetric changes

Author(s): Lorena I Petrella, João M Castelhano, Mario Ribeiro, José V Sereno, Sónia I Gonçalves, Mário N Laço, Michael R Hayden, A Cristina Rego, Miguel Castelo-Branco
Published in: Human Molecular Genetics, Issue 27/12, 2018, Page(s) 2125-2137, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddy119

Cordycepin activates autophagy through AMPK phosphorylation to reduce abnormalities in Machado–Joseph disease models

Author(s): Adriana Marcelo, Filipa Brito, Sara Carmo-Silva, Carlos A Matos, João Alves-Cruzeiro, Ana Vasconcelos-Ferreira, Rebekah Koppenol, Liliana Mendonça, Luís Pereira de Almeida, Clévio Nóbrega
Published in: Human Molecular Genetics, Issue 28/1, 2018, Page(s) 51-63, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddy328

Control of glutamate release by complexes of adenosine and cannabinoid receptors

Author(s): Attila Köfalvi, Estefanía Moreno, Arnau Cordomí, Ning-Sheng Cai, Victor Fernández-Dueñas, Samira G. Ferreira, Ramón Guixà-González, Marta Sánchez-Soto, Hideaki Yano, Verònica Casadó-Anguera, Rodrigo A. Cunha, Ana Maria Sebastião, Francisco Ciruela, Leonardo Pardo, Vicent Casadó, Sergi Ferré
Published in: BMC Biology, Issue 18/1, 2020, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-020-0739-0

Recurrent Stroke With Rivaroxaban Compared With Aspirin According to Predictors of Atrial Fibrillation

Author(s): Jeff S. Healey, David J. Gladstone, Balakumar Swaminathan, Jens Eckstein, Hardi Mundl, Andrew E. Epstein, Karl Georg Haeusler, Robert Mikulik, Scott E. Kasner, Danilo Toni, Antonio Arauz, George Ntaios, Graeme J. Hankey, Kanjana Perera, Jorge Pagola, Ashfaq Shuaib, Helmi Lutsep, Xiaomeng Yang, Shinichiro Uchiyama, Matthias Endres, Shelagh B. Coutts, Michal Karlinski, Anna Czlonkowska, Carlos A. Mo
Published in: JAMA Neurology, Issue 76/7, 2019, Page(s) 764, ISSN 2168-6149
Publisher: American Medical Association
DOI: 10.1001/jamaneurol.2019.0617

Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease

Author(s): Niklas Mattsson, Colin Groot, Willemijn J. Jansen, Susan M. Landau, Victor L. Villemagne, Sebastiaan Engelborghs, Mark M. Mintun, Alberto Lleo, José Luis Molinuevo, William J. Jagust, Giovanni B. Frisoni, Adrian Ivanoiu, Gaël Chételat, Catarina Resende de Oliveira, Karen M. Rodrigue, Johannes Kornhuber, Anders Wallin, Aleksandra Klimkowicz-Mrowiec, Ramesh Kandimalla, Julius Popp, Pauline P. Aal
Published in: Alzheimer's & Dementia, Issue 14/7, 2018, Page(s) 913-924, ISSN 1552-5260
Publisher: Elsevier BV
DOI: 10.1016/j.jalz.2018.02.009

Erlangen Score as a tool to predict progression from mild cognitive impairment to dementia in Alzheimer’s disease

Author(s): Inês Baldeiras, Isabel Santana, Maria João Leitão, Daniela Vieira, Diana Duro, Barbara Mroczko, Johannes Kornhuber, Piotr Lewczuk
Published in: Alzheimer's Research & Therapy, Issue 11/1, 2019, ISSN 1758-9193
Publisher: BioMed Central
DOI: 10.1186/s13195-018-0456-x

Chronic hyperglycemia impairs hippocampal neurogenesis and memory in an Alzheimer’s disease mouse model

Author(s): Elisabete Ferreiro, Mariagrazia Lanzillo, Diogo Canhoto, António M. Carvalho da Silva, Sandra I. Mota, Inês S. Dias, Ildete L. Ferreira, Ana R. Fontes, Giorgia Mastrella, Paulo Pinheiro, Jorge Valero, A. Cristina Rego
Published in: Neurobiology of Aging, Issue 92, 2020, Page(s) 98-113, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2020.04.003

Addition of the Aβ42/40 ratio to the cerebrospinal fluid biomarker profile increases the predictive value for underlying Alzheimer’s disease dementia in mild cognitive impairment

Author(s): Inês Baldeiras, Isabel Santana, Maria João Leitão, Helena Gens, Rui Pascoal, Miguel Tábuas-Pereira, José Beato-Coelho, Diana Duro, Maria Rosário Almeida, Catarina Resende Oliveira
Published in: Alzheimer's Research & Therapy, Issue 10/1, 2018, ISSN 1758-9193
Publisher: BioMed Central
DOI: 10.1186/s13195-018-0362-2

Shaping the Nrf2-ARE-related pathways in Alzheimer’s and Parkinson’s diseases

Author(s): Lígia Fão, Sandra I. Mota, A. Cristina Rego
Published in: Ageing Research Reviews, Issue 54, 2019, Page(s) 100942, ISSN 1568-1637
Publisher: Elsevier BV
DOI: 10.1016/j.arr.2019.100942

Mitochondrial and Redox-Based Therapeutic Strategies in Huntington's Disease

Author(s): Lígia Fão, Ana Cristina Rego
Published in: Antioxidants & Redox Signaling, Issue 34/8, 2021, Page(s) 650-673, ISSN 1523-0864
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/ars.2019.8004

mtDNA copy number associated with age of onset in familial amyloid polyneuropathy

Author(s): Diana Santos, Maria João Santos, Miguel Alves-Ferreira, Teresa Coelho, Jorge Sequeiros, Isabel Alonso, Pedro Oliveira, Alda Sousa, Carolina Lemos, Manuela Grazina
Published in: Journal of Neurology, Neurosurgery & Psychiatry, Issue 89/3, 2018, Page(s) 300-304, ISSN 0022-3050
Publisher: BMJ Publishing Group
DOI: 10.1136/jnnp-2017-316657

Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia

Author(s): Franc Llorens, Peter Hermann, Anna Villar-Piqué, Daniela Diaz-Lucena, Katarina Nägga, Oskar Hansson, Isabel Santana, Matthias Schmitz, Christian Schmidt, Daniela Varges, Stefan Goebel, Julien Dumurgier, Henrik Zetterberg, Kaj Blennow, Claire Paquet, Inês Baldeiras, Isidro Ferrer, Inga Zerr
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-14373-2

Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer’s disease features in cortical neurons

Author(s): Diana F. Silva, Emanuel Candeias, A. Raquel Esteves, João D. Magalhães, I. Luísa Ferreira, Daniela Nunes-Costa, A. Cristina Rego, Nuno Empadinhas, Sandra M. Cardoso
Published in: Journal of Neuroinflammation, Issue 17/1, 2020, ISSN 1742-2094
Publisher: BioMed Central
DOI: 10.1186/s12974-020-02004-y

Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease

Author(s): Catarina Oliveira Miranda, Adriana Marcelo, Teresa Pereira Silva, João Barata, Ana Vasconcelos-Ferreira, Dina Pereira, Clévio Nóbrega, Sónia Duarte, Inês Barros, Joana Alves, José Sereno, Lorena Itatí Petrella, João Castelhano, Vitor Hugo Paiva, Paulo Rodrigues-Santos, Vera Alves, Isabel Nunes-Correia, Rui Jorge Nobre, Célia Gomes, Miguel Castelo-Branco, Luís Pereira de Almeida
Published in: Molecular Therapy, Issue 26/9, 2018, Page(s) 2131-2151, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2018.07.007

Distinct subnetworks of the thalamic reticular nucleus

Author(s): Yinqing Li, Violeta G. Lopez-Huerta, Xian Adiconis, Kirsten Levandowski, Soonwook Choi, Sean K. Simmons, Mario A. Arias-Garcia, Baolin Guo, Annie Y. Yao, Timothy R. Blosser, Ralf D. Wimmer, Tomomi Aida, Alexander Atamian, Tina Naik, Xuyun Sun, Dasheng Bi, Diya Malhotra, Cynthia C. Hession, Reut Shema, Marcos Gomes, Taibo Li, Eunjin Hwang, Alexandra Krol, Monika Kowalczyk, João Peça, Gang Pan, Mi
Published in: Nature, Issue 583/7818, 2020, Page(s) 819-824, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2504-5

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