Genomics and Metabolomics in a Host-Microbe Symbiosis Network

Deliverables

Websites, patent fillings, videos etc. (2)

Creation of Social media accounts for SymbNET

Creation of Social media accounts for SymbNET

Creation of SymbNET´s identity and website

Creation of SymbNETs identity and website

Publications

Peer reviewed articles (95)

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

Author(s): Monika Bambouskova, Laurent Gorvel, Vicky Lampropoulou, Alexey Sergushichev, Ekaterina Loginicheva, Kendall Johnson, Daniel Korenfeld, Mary Elizabeth Mathyer, Hyeryun Kim, Li-Hao Huang, Dustin Duncan, Howard Bregman, Abdurrahman Keskin, Andrea Santeford, Rajendra S. Apte, Raghav Sehgal, Britney Johnson, Gaya K. Amarasinghe, Miguel P. Soares, Takashi Satoh, Shizuo Akira, Tsonwin Hai, Cristina de Gu
Published in: Nature, 556/7702, 2018, Page(s) 501-504, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0052-z

Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice

Author(s): Mateo Murillo-León, Urs B. Müller, Ines Zimmermann, Shishir Singh, Pia Widdershooven, Cláudia Campos, Catalina Alvarez, Stephanie Könen-Waisman, Nahleen Lukes, Zsolt Ruzsics, Jonathan C. Howard, Martin Schwemmle, Tobias Steinfeldt
Published in: Nature Communications, 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-09200-2

High Heterogeneity of Multidrug-Resistant Enterobacteriaceae Fecal Levels in Hospitalized Patients Is Partially Driven by Intravenous β-Lactams

Author(s): Ana Djukovic, Eva M. González-Barberá, Jaime Sanz, Alejandro Artacho, Iván Peñaranda, Beatriz Herrera, María José Garzón, Miguel Salavert, José Luis López-Hontangas, Karina B. Xavier, Bernhard Kuster, Laurent Debrauwer, Jean-Marc Rolain, Miguel A. Sanz, Joao B. Xavier, Carles Ubeda
Published in: Antimicrobial Agents and Chemotherapy, 64/2, 2020, ISSN 0066-4804
Publisher: American Society for Microbiology
DOI: 10.1128/aac.01415-19

Host miRNA-21 promotes liver dysfunction by targeting small intestinal Lactobacillus in mice

Author(s): André A. Santos, Marta B. Afonso, Ricardo S. Ramiro, David Pires, Madalena Pimentel, Rui E. Castro, Cecília M.P. Rodrigues
Published in: Gut Microbes, 12/1, 2020, Page(s) 1840766, ISSN 1949-0976
Publisher: Landes Bioscience
DOI: 10.1080/19490976.2020.1840766

Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis

Author(s): Francesc Coll, Jody Phelan, Grant A. Hill-Cawthorne, Mridul B. Nair, Kim Mallard, Shahjahan Ali, Abdallah M. Abdallah, Saad Alghamdi, Mona Alsomali, Abdallah O. Ahmed, Stephanie Portelli, Yaa Oppong, Adriana Alves, Theolis Barbosa Bessa, Susana Campino, Maxine Caws, Anirvan Chatterjee, Amelia C. Crampin, Keertan Dheda, Nicholas Furnham, Judith R. Glynn, Louis Grandjean, Dang Minh Ha, Rumina Hasan,
Published in: Nature Genetics, 50/2, 2018, Page(s) 307-316, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-017-0029-0

The OmpR Regulator of Burkholderia multivorans Controls Mucoid-to-Nonmucoid Transition and Other Cell Envelope Properties Associated with Persistence in the Cystic Fibrosis Lung

Author(s): Inês N. Silva, Filipa D. Pessoa, Marcelo J. Ramires, Mário R. Santos, Jörg D. Becker, Vaughn S. Cooper, Leonilde M. Moreira
Published in: Journal of Bacteriology, 200/17, 2018, ISSN 0021-9193
Publisher: American Society for Microbiology
DOI: 10.1128/jb.00216-18

Synthesis and biological activity of a potent optically pure autoinducer-2 quorum sensing agonist

Author(s): Osvaldo S. Ascenso, Inês M. Torcato, Ana Sofia Miguel, João C. Marques, Karina B. Xavier, M. Rita Ventura, Christopher D. Maycock
Published in: Bioorganic Chemistry, 85, 2019, Page(s) 75-81, ISSN 0045-2068
Publisher: Academic Press
DOI: 10.1016/j.bioorg.2018.12.022

Role of CD3+γδ-T cells in the association of obstructive sleep-disordered breathing and cancer

Author(s): Richard Staats, Raquel Rodrigues, André Barros, Leonor Bacelar-Nicolau, Margarida Aguiar, Dina Fernandes, Susana Moreira, André Simões, Bruno Silva-Santos, João Valença Rodrigues, Cristina Barbara, António Bugalho de Almeida, Luís F. Ferreira Moita
Published in: Sleep and Breathing, 24/4, 2020, Page(s) 1673-1674, ISSN 1520-9512
Publisher: Thieme Medical Publishers
DOI: 10.1007/s11325-019-01842-2

Mutation accumulation and horizontal gene transfer in Escherichia coli colonizing the gut of old mice

Author(s): Hugo C. Barreto, Nelson Frazão, Ana Sousa, Anke Konrad, Isabel Gordo
Published in: Communicative & Integrative Biology, 13/1, 2020, Page(s) 89-96, ISSN 1942-0889
Publisher: Landes Bioscience
DOI: 10.1080/19420889.2020.1783059

Labile heme impairs hepatic microcirculation and promotes hepatic injury

Author(s): Franziska A. Englert, Raphael A. Seidel, Kerstin Galler, Zelia Gouveia, Miguel P. Soares, Ute Neugebauer, Mark G. Clemens, Christoph Sponholz, Stefan H. Heinemann, Georg Pohnert, Michael Bauer, Sebastian Weis
Published in: Archives of Biochemistry and Biophysics, 672, 2019, Page(s) 108075, ISSN 0003-9861
Publisher: Academic Press
DOI: 10.1016/j.abb.2019.108075

Celastrol Efficacy by Oral Administration in the Adjuvant-Induced Arthritis Model.

Author(s): Cascão R, Vidal B, Carvalho T, Lopes IP, Romão VC, Goncalves J, Moita LF, Fonseca JE
Published in: Front Med (Lausanne), 2020 Sep 8;7:455, 2020, ISSN 2296-858X
Publisher: Chinese Higher Education Press and Springer Science+Business Media.
DOI: 10.3389/fmed.2020.00455

Irgm2 and Gate‐16 cooperatively dampen Gram‐negative bacteria‐induced caspase‐11 response

Author(s): Elif Eren, Rémi Planès, Salimata Bagayoko, Pierre‐Jean Bordignon, Karima Chaoui, Audrey Hessel, Karin Santoni, Miriam Pinilla, Brice Lagrange, Odile Burlet‐Schiltz, Jonathan C Howard, Thomas Henry, Masahiro Yamamoto, Etienne Meunier
Published in: EMBO reports, 21/11, 2020, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.202050829

Specific Eco-evolutionary Contexts in the Mouse Gut Reveal Escherichia coli Metabolic Versatility

Author(s): João Barroso-Batista, Miguel F. Pedro, Joana Sales-Dias, Catarina J.G. Pinto, Jessica A. Thompson, Helena Pereira, Jocelyne Demengeot, Isabel Gordo, Karina B. Xavier
Published in: Current Biology, 30/6, 2020, Page(s) 1049-1062.e7, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2020.01.050

Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils

Author(s): Kaori L. Fonseca, Ana Raquel Maceiras, Rita Matos, Luisa Simoes-Costa, Jeremy Sousa, Baltazar Cá, Leandro Barros, Ana Isabel Fernandes, Stefan Mereiter, Ricardo Reis, Joana Gomes, Gustavo Tapia, Paula Rodríguez-Martínez, Montse Martín-Céspedes, Sergo Vashakidze, Shota Gogishvili, Keti Nikolaishvili, Rui Appelberg, Fátima Gärtner, Pedro N. S. Rodrigues, Cristina Vilaplana, Celso A. Reis, Ana
Published in: Mucosal Immunology, 13/5, 2020, Page(s) 836-848, ISSN 1933-0219
Publisher: Nature Publishing Group
DOI: 10.1038/s41385-020-0277-7

Bacterial Call to Arms for Warfare at the Infection Site

Author(s): Vitor Cabral, Karina B. Xavier
Published in: Cell Host & Microbe, 23/3, 2018, Page(s) 285-287, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2018.02.009

Drosophila melanogaster establishes a species-specific mutualistic interaction with stable gut-colonizing bacteria

Author(s): Inês S. Pais, Rita S. Valente, Marta Sporniak, Luis Teixeira
Published in: PLOS Biology, 16/7, 2018, Page(s) e2005710, ISSN 1545-7885
Publisher: PLOS
DOI: 10.1371/journal.pbio.2005710

Low mutational load and high mutation rate variation in gut commensal bacteria

Author(s): Ricardo S. Ramiro, Paulo Durão, Claudia Bank, Isabel Gordo
Published in: PLOS Biology, 18/3, 2020, Page(s) e3000617, ISSN 1545-7885
Publisher: PLOS
DOI: 10.1371/journal.pbio.3000617

Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells

Author(s): Cristina Ferreira, Leandro Barros, Marta Baptista, Birte Blankenhaus, André Barros, Patrícia Figueiredo-Campos, Špela Konjar, Alexandra Lainé, Nadine Kamenjarin, Ana Stojanovic, Adelheid Cerwenka, Hans C. Probst, Julien C. Marie, Marc Veldhoen
Published in: Nature Immunology, 21/7, 2020, Page(s) 766-776, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-020-0674-9

Insights into tuberculosis: A survival analysis of time to recurrence in Portugal, between 2002 and 2009

Author(s): P. Soares, R. Duarte, M.G.M. Gomes, C. Rocha, J.S. Lopes
Published in: Pulmonology, 26/5, 2020, Page(s) 318-320, ISSN 2531-0437
Publisher: Portuguese Society of Pulmonology
DOI: 10.1016/j.pulmoe.2020.03.010

Readapting to DCV Infection without Wolbachia: Frequency Changes of Drosophila Antiviral Alleles Can Replace Endosymbiont Protection

Author(s): Vitor G Faria, Nelson E Martins, Christian Schlötterer, Élio Sucena
Published in: Genome Biology and Evolution, 10/7, 2018, Page(s) 1783-1791, ISSN 1759-6653
Publisher: Oxford University Press
DOI: 10.1093/gbe/evy137

Evolutionary change in the human gut microbiome: From a static to a dynamic view

Author(s): Isabel Gordo
Published in: PLOS Biology, 17/2, 2019, Page(s) e3000126, ISSN 1545-7885
Publisher: PLOS
DOI: 10.1371/journal.pbio.3000126

Synthesis of d-desthiobiotin-AI-2 as a novel chemical probe for autoinducer-2 quorum sensing receptors

Author(s): Vanessa Miranda, Inês M. Torcato, Karina B. Xavier, M. Rita Ventura
Published in: Bioorganic Chemistry, 92, 2019, Page(s) 103200, ISSN 0045-2068
Publisher: Academic Press
DOI: 10.1016/j.bioorg.2019.103200

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome as a Hyper-Regulated Immune System Driven by an Interplay Between Regulatory T Cells and Chronic Human Herpesvirus Infections

Author(s): Nuno Sepúlveda, Jorge Carneiro, Eliana Lacerda, Luis Nacul
Published in: Frontiers in Immunology, 10, 2019, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2019.02684

Increasing macrolide resistance among Streptococcus agalactiae causing invasive disease in non-pregnant adults was driven by a single capsular-transformed lineage, Portugal, 2009 to 2015

Author(s): Elísia Lopes, Tânia Fernandes, Miguel P Machado, João André Carriço, José Melo-Cristino, Mário Ramirez, Elisabete R Martins
Published in: Eurosurveillance, 23/21, 2018, ISSN 1560-7917
Publisher: European Centre for Disease Prevention and Control
DOI: 10.2807/1560-7917.es.2018.23.21.1700473

Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis

Author(s): Lúcia Moreira-Teixeira, Philippa J. Stimpson, Evangelos Stavropoulos, Sabelo Hadebe, Probir Chakravarty, Marianna Ioannou, Iker Valle Aramburu, Eleanor Herbert, Simon L. Priestnall, Alejandro Suarez-Bonnet, Jeremy Sousa, Kaori L. Fonseca, Qian Wang, Sergo Vashakidze, Paula Rodríguez-Martínez, Cristina Vilaplana, Margarida Saraiva, Venizelos Papayannopoulos, Anne O’Garra
Published in: Nature Communications, 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-19412-6

Ferritin H Deficiency in Myeloid Compartments Dysregulates Host Energy Metabolism and Increases Susceptibility to Mycobacterium tuberculosis Infection

Author(s): Vineel P. Reddy, Krishna C. Chinta, Vikram Saini, Joel N. Glasgow, Travis D. Hull, Amie Traylor, Fernanda Rey-Stolle, Miguel P. Soares, Rajhmun Madansein, Md Aejazur Rahman, Coral Barbas, Kievershen Nargan, Threnesan Naidoo, Pratistadevi K. Ramdial, James F. George, Anupam Agarwal, Adrie J. C. Steyn
Published in: Frontiers in Immunology, 9, 2018, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2018.00860

Genomic Analysis of European Drosophila melanogaster Populations Reveals Longitudinal Structure, Continent-Wide Selection, and Previously Unknown DNA Viruses

Author(s): Martin Kapun, Maite G Barrón, Fabian Staubach, Darren J Obbard, R Axel W Wiberg, Jorge Vieira, Clément Goubert, Omar Rota-Stabelli, Maaria Kankare, María Bogaerts-Márquez, Annabelle Haudry, Lena Waidele, Iryna Kozeretska, Elena G Pasyukova, Volker Loeschcke, Marta Pascual, Cristina P Vieira, Svitlana Serga, Catherine Montchamp-Moreau, Jessica Abbott, Patricia Gibert, Damiano Porcelli, Nico Pos
Published in: Molecular Biology and Evolution, 37/9, 2020, Page(s) 2661-2678, ISSN 0737-4038
Publisher: Oxford University Press
DOI: 10.1093/molbev/msaa120

M. tuberculosis Reprograms Hematopoietic Stem Cells to Limit Myelopoiesis and Impair Trained Immunity

Author(s): Nargis Khan, Jeffrey Downey, Joaquin Sanz, Eva Kaufmann, Birte Blankenhaus, Alain Pacis, Erwan Pernet, Eisha Ahmed, Silvia Cardoso, Anastasia Nijnik, Bruce Mazer, Christopher Sassetti, Marcel A. Behr, Miguel P. Soares, Luis B. Barreiro, Maziar Divangahi
Published in: Cell, 183/3, 2020, Page(s) 752-770.e22, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.09.062

Age, tissue, genotype and virus infection regulate Wolbachia levels in Drosophila

Author(s): Rupinder Kaur, Julien Martinez, Omar Rota‐Stabelli, Francis M. Jiggins, Wolfgang J. Miller
Published in: Molecular Ecology, 29/11, 2020, Page(s) 2063-2079, ISSN 0962-1083
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/mec.15462

Spider mites escape bacterial infection by avoiding contaminated food

Author(s): Flore Zélé, Gonçalo Santos-Matos, Alexandre R. T. Figueiredo, Cátia Eira, Catarina Pinto, Telma G. Laurentino, Élio Sucena, Sara Magalhães
Published in: Oecologia, 189/1, 2019, Page(s) 111-122, ISSN 0029-8549
Publisher: Springer Verlag
DOI: 10.1007/s00442-018-4316-y

T-Cell Hyperactivation and Paralysis in Severe COVID-19 Infection Revealed by Single-Cell Analysis

Author(s): Bahire Kalfaoglu, José Almeida-Santos, Chanidapa Adele Tye, Yorifumi Satou, Masahiro Ono
Published in: Frontiers in Immunology, 11, 2020, ISSN 1664-3224
Publisher: International Union of Immunological Societies (IUIS).
DOI: 10.3389/fimmu.2020.589380

Treatment timing shifts the benefits of short and long antibiotic treatment over infection

Author(s): Erida Gjini, Francisco F S Paupério, Vitaly V Ganusov
Published in: Evolution, Medicine, and Public Health, 2020/1, 2020, Page(s) 249-263, ISSN 2050-6201
Publisher: Oxford Academic
DOI: 10.1093/emph/eoaa033

Microbial Diversity and Toxin Risk in Tropical Freshwater Reservoirs of Cape Verde

Author(s): Ana Semedo-Aguiar, Jose Pereira-Leal, Ricardo Leite
Published in: Toxins, 10/5, 2018, Page(s) 186, ISSN 2072-6651
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins10050186

Identification of novel autoinducer-2 receptors in Clostridia reveals plasticity in the binding site of the LsrB receptor family

Author(s): Inês M. Torcato, Meghann R. Kasal, Patrícia H. Brito, Stephen T. Miller, Karina B. Xavier
Published in: Journal of Biological Chemistry, 294/12, 2019, Page(s) 4450-4463, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra118.006938

Rampant loss of social traits during domestication of a Bacillus subtilis natural isolate

Author(s): Hugo C. Barreto, Tiago N. Cordeiro, Adriano O. Henriques, Isabel Gordo
Published in: Scientific Reports, 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-76017-1

The Landscape of Adaptive Evolution of a Gut Commensal Bacteria in Aging Mice

Author(s): Hugo C. Barreto, Ana Sousa, Isabel Gordo
Published in: Current Biology, 30/6, 2020, Page(s) 1102-1109.e5, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2020.01.037

Massive dissemination of a SARS-CoV-2 Spike Y839 variant in Portugal

Author(s): Vítor Borges, Joana Isidro, Helena Cortes-Martins, Sílvia Duarte, Luís Vieira, Ricardo Leite, Isabel Gordo, Constantino P. Caetano, Baltazar Nunes, Regina Sá, Ana Oliveira, Raquel Guiomar, João Paulo Gomes
Published in: Emerging Microbes & Infections, 9/1, 2020, Page(s) 2488-2496, ISSN 2222-1751
Publisher: Nature Publishing Group
DOI: 10.1080/22221751.2020.1844552

Portuguese in vitro antibiotic susceptibilities favor current nontuberculous mycobacteria treatment guidelines

Author(s): Vera Durão, Anabela Silva, Rita Macedo, Paulo Durão, André Santos-Silva, Raquel Duarte
Published in: Pulmonology, 25/3, 2019, Page(s) 162-167, ISSN 2531-0437
Publisher: Portuguese Society of Pulmonology
DOI: 10.1016/j.pulmoe.2018.09.001

Variation in Wolbachia cidB gene, but not cidA , is associated with cytoplasmic incompatibility mod phenotype diversity in Culex pipiens

Author(s): Manon Bonneau, Beniamino Caputo, Aude Ligier, Rudy Caparros, Sandra Unal, Marco Perriat‐Sanguinet, Daniele Arnoldi, Mathieu Sicard, Mylène Weill
Published in: Molecular Ecology, 28/21, 2019, Page(s) 4725-4736, ISSN 0962-1083
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/mec.15252

Heme Oxygenase-1 Induction by Blood-Feeding Arthropods Controls Skin Inflammation and Promotes Disease Tolerance

Author(s): Thiago DeSouza-Vieira, Eva Iniguez, Tiago D. Serafim, Waldionê de Castro, Subir Karmakar, Maria M. Disotuar, Pedro Cecilio, Joshua R. Lacsina, Claudio Meneses, Bianca M. Nagata, Silvia Cardoso, Daniel E. Sonenshine, Ian N. Moore, Valeria M. Borges, Ranadhir Dey, Miguel P. Soares, Hira L. Nakhasi, Fabiano Oliveira, Jesus G. Valenzuela, Shaden Kamhawi
Published in: Cell Reports, 33/4, 2020, Page(s) 108317, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108317

Inflammasome activation and IL-1 signaling during placental malaria induce poor pregnancy outcomes

Author(s): Aramys S. Reis, Renato Barboza, Oscar Murillo, André Barateiro, Erika P. M. Peixoto, Flávia A. Lima, Vinícius M. Gomes, Jamille G. Dombrowski, Vinícius N. C. Leal, Franciele Araujo, Carla L. Bandeira, Rosana B. D. Araujo, Rita Neres, Rodrigo M. Souza, Fabio T. M. Costa, Alessandra Pontillo, Estela Bevilacqua, Carsten Wrenger, Gerhard Wunderlich, Giuseppe Palmisano, Leticia Labriola, Karina R.
Published in: Science Advances, 6/10, 2020, Page(s) eaax6346, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.aax6346

Short communication: Four cases of Taenia saginata taeniasis in urban Venezuelan communities

Author(s): Glenda Rojas, Maria Martínez, Yeasiry Corrales, Victor Mijares, Luisa León, Claudio Medina, Elizabeth Ferrer, R. Michael E. Parkhouse, Maria M. Cortéz
Published in: Journal of Helminthology, 94, 2020, ISSN 0022-149X
Publisher: CABI Publishing
DOI: 10.1017/s0022149x1900021x

Model-based inference from multiple dose, time course data reveals Wolbachia effects on infection profiles of type 1 dengue virus in Aedes aegypti

Author(s): Caetano Souto-Maior, Gabriel Sylvestre, Fernando Braga Stehling Dias, M. Gabriela M. Gomes, Rafael Maciel-de-Freitas
Published in: PLOS Neglected Tropical Diseases, 12/3, 2018, Page(s) e0006339, ISSN 1935-2735
Publisher: PLOS
DOI: 10.1371/journal.pntd.0006339

First Report of Native Parasitoids of Fall Armyworm Spodoptera frugiperda Smith (Lepidoptera: Noctuidae) in Mozambique

Author(s): Albasini Caniço, António Mexia, Luisa Santos
Published in: Insects, 11/9, 2020, Page(s) 615, ISSN 2075-4450
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/insects11090615

Heme oxygenase-1 orchestrates the immunosuppressive program of tumor-associated macrophages

Author(s): Emmanuelle Alaluf, Benoît Vokaer, Aurélie Detavernier, Abdulkader Azouz, Marion Splittgerber, Alice Carrette, Louis Boon, Frédérick Libert, Miguel P. Soares, Alain Le Moine, Stanislas Goriely
Published in: JCI Insight, 2020, ISSN 2379-3708
Publisher: ASCI
DOI: 10.1172/jci.insight.133929

Challenges in Clinical Metaproteomics Highlighted by the Analysis of Acute Leukemia Patients with Gut Colonization by Multidrug-Resistant Enterobacteriaceae

Author(s): Julia Rechenberger, Patroklos Samaras, Anna Jarzab, Juergen Behr, Martin Frejno, Ana Djukovic, Jaime Sanz, Eva M. González-Barberá, Miguel Salavert, Jose Luis López-Hontangas, Karina B. Xavier, Laurent Debrauwer, Jean-Marc Rolain, Miguel Sanz, Marc Garcia-Garcera, Mathias Wilhelm, Carles Ubeda, Bernhard Kuster
Published in: Proteomes, 7/1, 2019, Page(s) 2, ISSN 2227-7382
Publisher: MDPI
DOI: 10.3390/proteomes7010002

T-cell dysregulation in COVID-19

Author(s): Bahire Kalfaoglu, José Almeida-Santos, Chanidapa Adele Tye, Yorifumi Satou, Masahiro Ono
Published in: Biochemical and Biophysical Research Communications, 2020, ISSN 0006-291X
Publisher: Academic Press
DOI: 10.1016/j.bbrc.2020.10.079

Radial Expansion Facilitates the Maintenance of Double Antibiotic Resistances

Author(s): Paulo Durão, Ricardo S. Ramiro, Cátia Pereira, Jernej Jurič, Delfina Pereira, Isabel Gordo
Published in: Antimicrobial Agents and Chemotherapy, 64/9, 2020, ISSN 0066-4804
Publisher: American Society for Microbiology
DOI: 10.1128/aac.00668-20

Microbiota Alters Urinary Bladder Weight and Gene Expression

Author(s): Blanka Roje, Anamaria Elek, Vinko Palada, Joana Bom, Aida Iljazović, Ana Šimić, Lana Sušak, Katarina Vilović, Till Strowig, Kristian Vlahoviček, Janoš Terzić
Published in: Microorganisms, 8/3, 2020, Page(s) 421, ISSN 2076-2607
Publisher: MDPI
DOI: 10.3390/microorganisms8030421

Bacterial interspecies quorum sensing in the mammalian gut microbiota

Author(s): Karina Bivar Xavier
Published in: Comptes Rendus Biologies, 341/5, 2018, Page(s) 297-299, ISSN 1631-0691
Publisher: Elsevier Masson
DOI: 10.1016/j.crvi.2018.03.006

Bradykinin Sequestration by Plasmodium berghei Infected Erythrocytes Conditions B2R Signaling and Parasite Uptake by Fetal Trophoblasts

Author(s): Luciana Vieira de Moraes, André Barateiro, Patrícia Marques Sousa, Carlos Penha-Gonçalves
Published in: Frontiers in Microbiology, 9, 2018, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2018.03106

Influenza A virus ribonucleoproteins form liquid organelles at endoplasmic reticulum exit sites

Author(s): Marta Alenquer, Sílvia Vale-Costa, Temitope Akhigbe Etibor, Filipe Ferreira, Ana Laura Sousa, Maria João Amorim
Published in: Nature Communications, 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-09549-4

Reciprocal contribution of clinical studies and the HP10 antigen ELISA for the diagnosis of extraparenchymal neurocysticercosis

Author(s): R. Michael E. Parkhouse, Arturo Carpio, Alfredo Campoverde, Patricia Sastre, Glenda Rojas, María Milagros Cortez
Published in: Acta Tropica, 178, 2018, Page(s) 119-123, ISSN 0001-706X
Publisher: Elsevier BV
DOI: 10.1016/j.actatropica.2017.11.005

An insight to HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) pathogenesis; evidence from high-throughput data integration and meta-analysis

Author(s): Sayed-Hamidreza Mozhgani, Mehran Piran, Mohadeseh Zarei-Ghobadi, Mohieddin Jafari, Seyed-Mohammad Jazayeri, Talat Mokhtari-Azad, Majid Teymoori-Rad, Narges Valizadeh, Hamid Farajifard, Mehdi Mirzaie, Azam Khamseh, Houshang Rafatpanah, Seyed-Abdolrahim Rezaee, Mehdi Norouzi
Published in: Retrovirology, 16/1, 2019, ISSN 1742-4690
Publisher: BioMed Central
DOI: 10.1186/s12977-019-0508-8

Disease Tolerance as an Inherent Component of Immunity

Author(s): Rui Martins, Ana Rita Carlos, Faouzi Braza, Jessica A. Thompson, Patricia Bastos-Amador, Susana Ramos, Miguel P. Soares
Published in: Annual Review of Immunology, 37/1, 2019, Page(s) 405-437, ISSN 0732-0582
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-immunol-042718-041739

Recovery of the Gut Microbiota after Antibiotics Depends on Host Diet, Community Context, and Environmental Reservoirs

Author(s): Katharine Michelle Ng, Andrés Aranda-Díaz, Carolina Tropini, Matthew Ryan Frankel, William Van Treuren, Colleen T. O’Loughlin, Bryan Douglas Merrill, Feiqiao Brian Yu, Kali M. Pruss, Rita Almeida Oliveira, Steven Kyle Higginbottom, Norma F. Neff, Michael Andrew Fischbach, Karina Bivar Xavier, Justin Laine Sonnenburg, Kerwyn Casey Huang
Published in: Cell Host & Microbe, 26/5, 2019, Page(s) 650-665.e4, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2019.10.011

Brain Endothelium: The “Innate Immunity Response Hypothesis” in Cerebral Malaria Pathogenesis

Author(s): Teresa F. Pais, Carlos Penha-Gonçalves
Published in: Frontiers in Immunology, 9, 2019, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2018.03100

Zinc inhibits lethal inflammatory shock by preventing microbe‐induced interferon signature in intestinal epithelium

Author(s): Jolien Souffriau, Steven Timmermans, Tineke Vanderhaeghen, Charlotte Wallaeys, Kelly Van Looveren, Lindsy Aelbrecht, Sylviane Dewaele, Jolien Vandewalle, Evy Goossens, Serge Verbanck, Filip Boyen, Melanie Eggermont, Lindsey De Commer, Riet De Rycke, Michiel De Bruyne, Raul Tito, Marlies Ballegeer, Sofie Vandevyver, Tiago Velho, Luis Ferreira Moita, Tino Hochepied, Karolien De Bosscher, Jeroen Raes
Published in: EMBO Molecular Medicine, 12/10, 2020, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201911917

Renal control of disease tolerance to malaria

Author(s): Susana Ramos, Ana Rita Carlos, Balamurugan Sundaram, Viktoria Jeney, Ana Ribeiro, Raffaella Gozzelino, Claudia Bank, Erida Gjini, Faouzi Braza, Rui Martins, Temitope Wilson Ademolue, Birte Blankenhaus, Zélia Gouveia, Pedro Faísca, Damian Trujillo, Sílvia Cardoso, Sofia Rebelo, Laura del Barrio, Abolfazl Zarjou, Subhashini Bolisetty, Anupam Agarwal, Miguel P. Soares
Published in: Proceedings of the National Academy of Sciences, 116/12, 2019, Page(s) 5681-5686, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1822024116

Innate Nutritional Immunity

Author(s): Gabriel Núñez, Kei Sakamoto, Miguel P. Soares
Published in: The Journal of Immunology, 201/1, 2018, Page(s) 11-18, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1800325

Evolutionary Mechanisms Shaping the Maintenance of Antibiotic Resistance

Author(s): Paulo Durão, Roberto Balbontín, Isabel Gordo
Published in: Trends in Microbiology, 26/8, 2018, Page(s) 677-691, ISSN 0966-842X
Publisher: Elsevier BV
DOI: 10.1016/j.tim.2018.01.005

A Comprehensive Review on the Interaction Between the Host GTPase Rab11 and Influenza A Virus

Author(s): Maria João Amorim
Published in: Frontiers in Cell and Developmental Biology, 6, 2019, ISSN 2296-634X
Publisher: Frontiers Media
DOI: 10.3389/fcell.2018.00176

Erwinia carotovora Quorum Sensing System Regulates Host-Specific Virulence Factors and Development Delay in Drosophila melanogaster

Author(s): Filipe J. D. Vieira, Pol Nadal-Jimenez, Luis Teixeira, Karina B. Xavier
Published in: mBio, 11/3, 2020, ISSN 2150-7511
Publisher: American Society for Microbiology
DOI: 10.1128/mbio.01292-20

Diagnosis of Taeniosis in rural Venezuelan communities: Preliminary characterization of a Taenia solium specific monoclonal (VP-1) Coproantigen ELISA

Author(s): R. Michael E Parkhouse, Glenda Rojas R, Cruz Manuel Aguilar, Claudio Medina, Elizabeth Ferrer, Maria M. Cortez Alcovedes
Published in: Acta Tropica, 207, 2020, Page(s) 105445, ISSN 0001-706X
Publisher: Elsevier BV
DOI: 10.1016/j.actatropica.2020.105445

Within host selection for faster replicating bacterial symbionts

Author(s): Ewa Chrostek, Luis Teixeira
Published in: PLOS ONE, 13/1, 2018, Page(s) e0191530, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0191530

Endocrine regulation of immunity in insects

Author(s): Catarina Nunes, Élio Sucena, Takashi Koyama
Published in: The FEBS Journal, 2020, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.15581

Detection of plasmid-mediated colistin resistance, mcr-1 gene, in Escherichia coli isolated from high-risk patients with acute leukemia in Spain

Author(s): Rym Lalaoui, Ana Djukovic, Sofiane Bakour, Jaime Sanz, Eva M. Gonzalez-Barbera, Miguel Salavert, Jose Luis López-Hontangas, Miguel A. Sanz, Karina B. Xavier, Bernhard Kuster, Laurent Debrauwer, Carles Ubeda, Jean-Marc Rolain
Published in: Journal of Infection and Chemotherapy, 25/8, 2019, Page(s) 605-609, ISSN 1341-321X
Publisher: Springer Verlag
DOI: 10.1016/j.jiac.2019.03.007

Evolutionary analysis of Mycobacterium bovis genotypes across Africa suggests co-evolution with livestock and humans

Author(s): Osvaldo Frederico Inlamea, Pedro Soares, Cassia Yumi Ikuta, Marcos Bryan Heinemann, Sara Juma Achá, Adelina Machado, José Soares Ferreira Neto, Margarida Correia-Neves, Teresa Rito
Published in: PLOS Neglected Tropical Diseases, 14/3, 2020, Page(s) e0008081, ISSN 1935-2735
Publisher: PLOS
DOI: 10.1371/journal.pntd.0008081

Unveiling Concealed Functions of Endosymbiotic Bacteria Harbored in the Ascomycete Stachylidium bicolor

Author(s): Celso Almeida, Cristina Silva Pereira, Victor Gonzalez-Menendez, Gerald Bills, Javier Pascual, Marina Sánchez-Hidalgo, Stefan Kehraus, Olga Genilloud
Published in: Applied and Environmental Microbiology, 84/15, 2018, ISSN 0099-2240
Publisher: American Society for Microbiology
DOI: 10.1128/aem.00660-18

Cross-Talk Between Iron and Glucose Metabolism in the Establishment of Disease Tolerance

Author(s): Ana Rita Carlos, Sebastian Weis, Miguel P. Soares
Published in: Frontiers in Immunology, 9, 2018, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2018.02498

Cheating on Cheaters Stabilizes Cooperation in Pseudomonas aeruginosa

Author(s): Özhan Özkaya, Roberto Balbontín, Isabel Gordo, Karina B. Xavier
Published in: Current Biology, 28/13, 2018, Page(s) 2070-2080.e6, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2018.04.093

Horizontal gene transfer overrides mutation in Escherichia coli colonizing the mammalian gut

Author(s): Nelson Frazão, Ana Sousa, Michael Lässig, Isabel Gordo
Published in: Proceedings of the National Academy of Sciences, 116/36, 2019, Page(s) 17906-17915, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1906958116

Experimental Evidence for Limited in vivo Virulence of Mycobacterium africanum

Author(s): Baltazar Cá, Kaori L. Fonseca, Jeremy Sousa, Ana Raquel Maceiras, Diana Machado, Lilica Sanca, Paulo Rabna, Pedro N. S. Rodrigues, Miguel Viveiros, Margarida Saraiva
Published in: Frontiers in Microbiology, 10, 2019, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2019.02102

Environmental Sources of Bacteria and Genetic Variation in Behavior Influence Host-Associated Microbiota

Author(s): Alexandra A. Mushegian, Roberto Arbore, Jean-Claude Walser, Dieter Ebert
Published in: Applied and Environmental Microbiology, 85/8, 2019, ISSN 0099-2240
Publisher: American Society for Microbiology
DOI: 10.1128/aem.01547-18

From Root to Tips: Sporulation Evolution and Specialization in Bacillus subtilis and the Intestinal Pathogen Clostridioides difficile

Author(s): Paula Ramos-Silva, Mónica Serrano, Adriano O Henriques
Published in: Molecular Biology and Evolution, 36/12, 2019, Page(s) 2714-2736, ISSN 0737-4038
Publisher: Oxford University Press
DOI: 10.1093/molbev/msz175

Intravital imaging of host‐parasite interactions in organs of the thoracic and abdominopelvic cavities

Author(s): Mariana De Niz, Tânia Carvalho, Carlos Penha‐Gonçalves, Carolina Agop‐Nersesian
Published in: Cellular Microbiology, 22/6, 2020, ISSN 1462-5814
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/cmi.13201

Ferritin regulates organismal energy balance and thermogenesis

Author(s): Birte Blankenhaus, Faouzi Braza, Rui Martins, Patricia Bastos-Amador, Ismael González-García, Ana Rita Carlos, Inês Mahu, Pedro Faisca, Jose Moura Nunes, Pedro Ventura, Verena Hoerr, Sebastian Weis, Joel Guerra, Silvia Cardoso, Ana Domingos, Miguel López, Miguel P. Soares
Published in: Molecular Metabolism, 24, 2019, Page(s) 64-79, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.03.008

The African Swine Fever Virus (ASFV) Topoisomerase II as a Target for Viral Prevention and Control

Author(s): João Coelho, Alexandre Leitão
Published in: Vaccines, 8/2, 2020, Page(s) 312, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8020312

Mutation S110L of H1N1 Influenza Virus Hemagglutinin: A Potent Determinant of Attenuation in the Mouse Model

Author(s): Amelia Nieto, Jasmina Vasilijevic, Nuno Brito Santos, Noelia Zamarreño, Pablo López, Maria Joao Amorim, Ana Falcon
Published in: Frontiers in Immunology, 10, 2019, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2019.00132

Titer regulation in arthropod-Wolbachia symbioses

Author(s): Sergio López-Madrigal, Elves H Duarte
Published in: FEMS Microbiology Letters, 366/23, 2019, ISSN 1574-6968
Publisher: Oxford University Press
DOI: 10.1093/femsle/fnz232

CXCL5-mediated recruitment of neutrophils into the peritoneal cavity of Gdf15 -deficient mice protects against abdominal sepsis

Author(s): Isa Santos, Henrique G. Colaço, Ana Neves-Costa, Elsa Seixas, Tiago R. Velho, Dora Pedroso, André Barros, Rui Martins, Nuno Carvalho, Didier Payen, Sebastian Weis, Hyon-Seung Yi, Minho Shong, Luís F. Moita
Published in: Proceedings of the National Academy of Sciences, 117/22, 2020, Page(s) 12281-12287, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1918508117

Klebsiella michiganensis transmission enhances resistance to Enterobacteriaceae gut invasion by nutrition competition

Author(s): Rita A. Oliveira, Katharine M. Ng, Margarida B. Correia, Vitor Cabral, Handuo Shi, Justin L. Sonnenburg, Kerwyn Casey Huang, Karina B. Xavier
Published in: Nature Microbiology, 5/4, 2020, Page(s) 630-641, ISSN 2058-5276
Publisher: nature publishing group
DOI: 10.1038/s41564-019-0658-4

Rab GTPase regulation of bacteria and protozoa phagocytosis occurs through the modulation of phagocytic receptor surface expression

Author(s): Elsa Seixas, Cristina Escrevente, Miguel C. Seabra, Duarte C. Barral
Published in: Scientific Reports, 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-31171-5

Transmission of porcine cysticercosis in the Portuguesa state of Venezuela

Author(s): R. Glenda Rojas, Fabián Patiño, Jesús Pérez, Claudio Medina, María Lares, César Méndez, Johan Aular, R. M. E. Parkhouse, María M. Cortéz
Published in: Tropical Animal Health and Production, 51/1, 2019, Page(s) 165-169, ISSN 0049-4747
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s11250-018-1671-y

Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection

Author(s): Jessica Sook Yuin Ho, Matthew Angel, Yixuan Ma, Elizabeth Sloan, Guojun Wang, Carles Martinez-Romero, Marta Alenquer, Vladimir Roudko, Liliane Chung, Simin Zheng, Max Chang, Yesai Fstkchyan, Sara Clohisey, Adam M. Dinan, James Gibbs, Robert Gifford, Rong Shen, Quan Gu, Nerea Irigoyen, Laura Campisi, Cheng Huang, Nan Zhao, Joshua D. Jones, Ingeborg van Knippenberg, Zeyu Zhu, Natasha Moshkina, Léa
Published in: Cell, 181/7, 2020, Page(s) 1502-1517.e23, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.05.035

Dysbiosis individualizes the fitness effect of antibiotic resistance in the mammalian gut

Author(s): Luís Leónidas Cardoso, Paulo Durão, Massimo Amicone, Isabel Gordo
Published in: Nature Ecology & Evolution, 4/9, 2020, Page(s) 1268-1278, ISSN 2397-334X
Publisher: American Society for Microbiology
DOI: 10.1038/s41559-020-1235-1

Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood–brain barrier

Author(s): Judith Hauptmann, Lisa Johann, Federico Marini, Maja Kitic, Elisa Colombo, Ilgiz A. Mufazalov, Martin Krueger, Khalad Karram, Sonja Moos, Florian Wanke, Florian C. Kurschus, Matthias Klein, Silvia Cardoso, Judith Strauß, Subhashini Bolisetty, Fred Lühder, Markus Schwaninger, Harald Binder, Ingo Bechman, Tobias Bopp, Anupam Agarwal, Miguel P. Soares, Tommy Regen, Ari Waisman
Published in: Acta Neuropathologica, 140/4, 2020, Page(s) 549-567, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-020-02187-x

Maternal-Fetal Conflict During Infection: Lessons From a Mouse Model of Placental Malaria

Author(s): Yash Pandya, Carlos Penha-Gonçalves
Published in: Frontiers in Microbiology, 10, 2019, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2019.01126

Variation in Wolbachia effects on Aedes mosquitoes as a determinant of invasiveness and vectorial capacity

Author(s): Jessica G. King, Caetano Souto-Maior, Larissa M. Sartori, Rafael Maciel-de-Freitas, M. Gabriela M. Gomes
Published in: Nature Communications, 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-03981-8

α-actinin accounts for the bioactivity of actin preparations in inducing STAT target genes in Drosophila melanogaster

Author(s): Oliver Gordon, Conor M Henry, Naren Srinivasan, Susan Ahrens, Anna Franz, Safia Deddouche, Probir Chakravarty, David Phillips, Roger George, Svend Kjaer, David Frith, Ambrosius P Snijders, Rita S Valente, Carolina J Simoes da Silva, Luis Teixeira, Barry Thompson, Marc S Dionne, Will Wood, Caetano Reis e Sousa
Published in: eLife, 7, 2018, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.38636

Genetics of Malaria Inflammatory Responses: A Pathogenesis Perspective

Author(s): Carlos Penha-Gonçalves
Published in: Frontiers in Immunology, 10, 2019, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2019.01771

Fetal and Maternal Innate Immunity Receptors Have Opposing Effects on the Severity of Experimental Malaria in Pregnancy: Beneficial Roles for Fetus-Derived Toll-Like Receptor 4 and Type I Interferon Receptor 1

Author(s): Lurdes Rodrigues-Duarte, Yash Pandya, Rita Neres, Carlos Penha-Gonçalves
Published in: Infection and Immunity, 86/5, 2018, ISSN 0019-9567
Publisher: American Society for Microbiology
DOI: 10.1128/iai.00708-17

A Th2 Cytokine Profile in Appendicular Lavage Fluid Suggests Allergy as a Possible Etiology for Acute Appendicitis

Author(s): Nuno Carvalho, André Barros, Hélder O. Coelho, Catarina F. Moita, Ana Neves-Costa, Dora Pedroso, Filipe C. Borges, Luís F. Moita, Paulo M. Costa
Published in: Mediators of Inflammation, 2019, 2019, Page(s) 1-5, ISSN 0962-9351
Publisher: Hindawi Publishing Corporation
DOI: 10.1155/2019/8146257

Understanding metabolic processes shaping adaptation of E. coli to the gut

Author(s): Miguel Pedro, João Batista-Barroso, Catarina Pinto, Joana Dias, Isabel Gordo, Karina Xavier
Published in: Access Microbiology, 1/1A, 2019, ISSN 2516-8290
Publisher: Microbiology Society
DOI: 10.1099/acmi.ac2019.po0215

Heme and hemolysis in innate immunity: adding insult to injury

Author(s): Rui Martins, Sylvia Knapp
Published in: Current Opinion in Immunology, 50, 2018, Page(s) 14-20, ISSN 0952-7915
Publisher: Elsevier BV
DOI: 10.1016/j.coi.2017.10.005

Book chapters (1)

Methods for the Measurement of Early Events in Toxoplasma gondii Immunity in Mouse Cells

Author(s): Catalina Alvarez, Ana Claudia Campos, Jonathan C. Howard, Joana Loureiro, Urs Benedikt Müller, Ana Lina Rodrigues
Published in: Toxoplasma gondii - Methods and Protocols, 2071, 2020, Page(s) 371-409, ISBN 978-1-4939-9856-2
Publisher: Springer US
DOI: 10.1007/978-1-4939-9857-9_20