Alpha1H: A Unique Bladder Cancer Therapeutic, Acting with Great Precision

Project Information

HAMLET-BC

Grant agreement ID: 954360

DOI

10.3030/954360

Project closed

EC signature date 11 June 2020

Start date 1 June 2020

End date 30 November 2022

Funded under

• INDUSTRIAL LEADERSHIP - Innovation In SMEs

Total cost

€ 3 138 778,00

EU contribution

€ 2 197 144,59

Coordinated by

HAMLET PHARMA AB
Sweden

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

Immunotherapy – a molecular solution to treating genetically susceptible patients with severe bladder pain syndrome?

Author(s): Wullt B, Butler DSC, Ambite I, Kinsolving J, Krintel C and Svanborg C
Published in: European Urology Open Science, 2021, ISSN 2666-1683
Publisher: Elsevier

Immunotherapy offers new molecular strategies to treat bacterial infections.

Author(s): Butler DSC, Wan M, Ambite I, Hien Tran T, Wullt B and Svanborg C.
Published in: Nature Reviews Urology, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group

Active bacterial modification of the host environment through RNA polymerase II inhibition

Author(s): Inès Ambite, Nina A. Filenko, Elisabed Zaldastanishvili, Daniel S.C. Butler, Thi Hien Tran, Arunima Chaudhuri, Parisa Esmaeili, Shahram Ahmadi, Sanchari Paul, Björn Wullt, Johannes Putze, Swaine L. Chen, Ulrich Dobrindt, Catharina Svanborg
Published in: Journal of Clinical Investigation, Issue 131/4, 2021, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci140333

Molecular determinants of disease severity in urinary tract infection.

Author(s): Ambite I, Butler DSC, Wan MLY, Rosenblad T, Tran TH Chao SM and Svanborg C.
Published in: Nature Reviews Urology, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group

Peptide–Oleate Complexes Create Novel Membrane-Bound Compartments

Author(s): Jesper S Hansen, Tuan Hiep Tran, Michele Cavalera, Sanchari Paul, Arunima Chaudhuri, Karin Lindkvist-Petersson, James C S Ho, Catharina Svanborg
Published in: Molecular Biology and Evolution, Issue 37/11, 2020, Page(s) 3083-3093, ISSN 0737-4038
Publisher: Oxford University Press
DOI: 10.1093/molbev/msaa138

A novel, peptide-based approach for targeting and killing tumor cells with greater precision.

Author(s): Brisuda A, Ho JCS, Kandiyal PS, Ng JTY, Ambite I, Butler DSC, Háček J, Wan MLY, Hien Tran T, Nadeem A, Hiep Tran T, Hastings A, Storm P, Fortunati DL, Esmaeili P, Novotna H, Horňák J, Mu YG, Mok KH, Babjuk M and Svanborg C.
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group

A bacterial protease depletes c-MYC and increases survival in mouse models of bladder and colon cancer

Author(s): Daniel S. C. Butler, Caterina Cafaro, Johannes Putze, Murphy Lam Yim Wan, Thi Hien Tran, Ines Ambite, Shahram Ahmadi, Sven Kjellström, Charlotte Welinder, Sing Ming Chao, Ulrich Dobrindt, Catharina Svanborg
Published in: Nature Biotechnology, 2021, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/s41587-020-00805-3

Bladder cancer therapy without toxicity—A dose‐escalation study of alpha1‐oleate

Author(s): Tran Thi Hien, Ines Ambite, Daniel Butler, Murphy Lam Yim Wan, Tuan Hiep Tran, Urban Höglund, Marek Babjuk, Catharina Svanborg
Published in: International Journal of Cancer, Issue 147/9, 2020, Page(s) 2479-2492, ISSN 0020-7136
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ijc.33019

Intellectual Property Rights

Patent (5)

COMBINATION OF A CHEMOTHERAPEUTIC AGENT AND ALPHA-LACTOGLUBULIN-OLEIC ACID COMPLEX FOR CANCER THERAPY

Application/Publication number: 20 771203
Date: 2020-08-19
Applicant(s): HAMLET PHARMA AB

PREPARATION OF BIOLOGICALLY ACTIVE COMPLEXES

Application/Publication number: 20 208669
Date: 2018-05-14
Applicant(s): HAMLET PHARMA AB

MILK PROTEIN - FATTY ACID COMPLEX

Application/Publication number: 17 187031
Date: 2013-08-08
Applicant(s): HAMLET PHARMA AB

PREPARATION OF BIOLOGICALLY ACTIVE COMPLEXES

Application/Publication number: 18 729327
Date: 2018-05-14
Applicant(s): HAMLET PHARMA AB

PROPHYLACTIC AND NUTRACEUTICAL THERAPY

Application/Publication number: 13 762204
Date: 2013-08-08
Applicant(s): HAMLET PHARMA AB