Objective
The proposal seeks to identify the mechanisms by which newly generated neurons in the adult olfactory bulb (OB) are integrated into a functional sensory processing network. The OB is one of only two brain regions in which newly generated cells continue to replace components of existing circuitry in adult life. How these newborn neurons are integrated into the OB network, establishing functional connections with existing cells and ensuring a seamless turnover of olfactory processing machinery, is an important issue for understanding how sensory information is processed in such a dynamic system. It also has relevance to clinical attempts at stimulating functional endogenous regeneration in the adult brain. Of particular interest is the fact that many newborn OB neurons die after reaching the bulb.
Do these neurons establish initial contacts with existing OB circuitry? If so, does the information received by a newborn OB cell from the existing OB network determine whether or not it survives? We will address the se questions through in vitro electrophysiological recordings of newborn neurons in the adult OB. These recordings will be undertaken both in normal mice and in mice in which electrical activity in the OB has been systematically altered.
We aim to discover whether surviving cells receive particular patterns of input that cells destined to die do not, and whether the survival of newborn OB neurons is affected if those patterns are disrupted. To this end, Matthew Grubb, a British researcher with doctoral experience in in-vivo electrophysiology and developmental neuroscience, will join the Lledo laboratory at the Institut Pasteur in Paris, a world leader in the field of adult neurogenesis and OB function.
The proposal will allow Mr Grubb to diversify his scientific expertise en route to an independent career in neuroscience research, and should generate significant data in an exciting scientific field with important potential clinical applications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.