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A multidisciplinary training network for the bioinspired development of glycomimetics tuning the Siglec-Sialoglycan axis

Project description

Researcher training in glyco-immune checkpoints

At the molecular and dynamic level, how do interactions between the immunomodulatory receptors Siglecs and their sialylated cognate ligands contribute to the aetiology of immune-related diseases like cancer? Is it possible to tune this axis to provide new therapeutic approaches? These are questions the EU-funded GLYTUNES project seeks to answer through a multidisciplinary European training network on glyco-immune checkpoints. Specifically, it will address the main priorities concerning the use of innovative methodological, interdisciplinary approaches for the treatment of human diseases. Guided by leaders in their respective fields of research, GLYTUNES involves seven academic partners and four companies (SMEs) from seven European countries. The programme will train 14 early-stage researchers.

Objective

GLYTUNES is a multidisciplinary European Training Network on glyco-immune checkpoints built to address the main priorities of the National and European research council regarding the use of innovative methodological, interdisciplinary approaches for the treatment of human diseases. The GLYTUNES program is based on high-level multidisciplinary and multisectoral training to i) understand at the molecular and dynamic level how (aberrant) interactions between the immunomodulatory receptors Siglecs and their sialylated cognate ligands contribute to the etiology of immune-related diseases (infectious, and cancer diseases), ii) how to tune this axis to provide new therapeutic approaches for the rational design and development of glycomimetics targeting the Siglec glyco-immune checkpoints.
To achieve this aim, an interdisciplinary, intersectoral, international European-based training programme within an outstanding collaborative research environment has been established, guided by leaders in their respective fields of research and in close association with industrial partners. GLYTUNES involves 7 academic partners and 4 companies (SMEs) from 7 European countries, combining world-class expertise in carbohydrate chemical and structural biology, drug design and computational chemistry, synthetic and medicinal chemistry, biophysics, biochemistry, glycoimmunology and molecular and medical microbiology. GLYTUNES will train 14 Early Stage Researchers (ESRs) in a highly integrated and collaborative environment, underpinned by extensive interactions between academic and industrial partners and by their experience in higher education, training and mentoring, and endowed with state-of-the art scientific and technical expertise and infrastructures. The ESRs will thus acquire scientific and transferable skills to make them highly competitive and new leaders in top EU academia and research institutions, healthcare and biotech job markets.

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Coordinator

UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Net EU contribution
€ 522 999,36
Address
Corso umberto i, 40
80138 Napoli
Italy

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Region
Sud Campania Napoli
Activity type
Higher or Secondary Education Establishments
Links
Other funding
€ 0,00

Participants (10)