Periodic Reporting for period 1 - Kite (The first non-invasive device to detect kidney reflux in children)
Reporting period: 2020-09-01 to 2021-08-31
Early diagnosis is vital, but current diagnostic techniques are invasive and either involve radiation exposure or are unreliable. The gold standard voiding cystourethrogram (VCUG) is traumatising and painful for the child and is stressful for parents and clinicians. The VCUG requires children to undergo urethral catheterisation, radiation exposure and forced bladder filling and emptying while awake. Behaviours of children after a VCUG are consistent with symptoms related to post-traumatic stress disorder.
The overall objectives of the EU-funded project are to advance the technology to limit the impact of motion in the signal (first reporting period) and to subsequently evaluate the clinical performance of a prototype system.
The system includes hardware, firmware and software elements under development in accordance with medical device standards and includes features to improve the SNR. The advance to 3D EIT has resulted in a significantly improved system that incorporates more electrodes and complementary sensors to detect shape and movement.
To effectively assess the suitability of the 3D EIT system, a preclinical study was warranted. A VUR model was created in pigs by stenting the bladder-ureter junction and fluoroscopy confirmed the presence of VUR. Multiple runs were performed with and without movement, the data generated is currently under analysis.