CORDIS provides links to public deliverables and publications of HORIZON projects.
Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .
Exploitable results
The aim of this research project has been the development of a new vaccine based on the knowledge of the pathogenesis of the Brucellosis bacteria and on the new technologies in the field of molecular genetics and immunology. Simultaneously, a diagnostic tool is being developed that will allow the differential diagnosis between animals treated with the new developed vaccine and infected animals.To achieve these goals Brucella protein antigens have been produced by recombinanat DNA techniques and their performance in serology has been evaluated. In parallel,presently available vaccine strains have been deleted in the genes encoding these diagnostic important proteins to avoid seroconversion upon vaccination. The strains have been studied in the mouse model to determine the residual virulence and to evaluate the protective effect upon challenge with a virulent Brucella strain. These experiments have yield encouraging results which warrent the furthur exploration of this vaccination and serology coupled system in a target animal like sheep or goats.
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