Objective This project will focus on the stimulation of a protective immune response in fish, the understanding of the mechanisms involved and further the ability to design optimal vaccines allowing a high protective immunity. Two fish species will be studied: salmonids (rainbow trout, Oncorhyncus mykiss, and salmon, Salmo salar) and cypronids (carp, Cyprinus carpio L.), and immune stimulation will be performed with two viral pathogens: the SVC virus (Spring Viremia of Carp) and the VHS virus (Viral Haemorrhagic Septicemia) infecting salmonids. We will use in particular a well characterized antigen from these viruses, the G protein which will be produced in microorganisms and purified. The stimulation of a protective immune response is divided into various essential steps that requires multi-disciplinary analysis: antibody production, antigen presentation, B-cells stimulation and T-cells functions, cytotoxicity, and cytokine-mediated response. These studies will lead to the determination of the best immunisation and design of optimal immunogens for fish vaccination. Fields of science agricultural sciencesagriculture, forestry, and fisheriesfisheriesmedical and health sciencesbasic medicineimmunologyimmunisationnatural sciencesbiological sciencesmicrobiologyvirologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesnatural sciencesbiological scienceszoologyichthyology Programme(s) FP3-AIR - Specific research and technological development and demonstration programme (EEC) in the field of agriculture and agro-industry, including fisheries, 1990-1994 Topic(s) 251 - Health of aquacultural stocks Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator SOCIETE EUROPEENNE DE BIOTECHNOLOGIE S.A. Address Rue bois saint jean 14 4102 Seraing Belgium See on map EU contribution € 0,00 Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all AGRICULTURAL UNIVERSITY OF WAGENINGEN Netherlands EU contribution € 0,00 Address Postbus 9101 6700 HB Wageningen See on map INIA Spain EU contribution € 0,00 Address Apartado de correos 8111 28040 Valdeolmos See on map UNIVERSITE DE LIEGE Belgium EU contribution € 0,00 Address Place du 20-aout 7 4000 Liege See on map UNIVERSITY OF ABERDEEN United Kingdom EU contribution € 0,00 Address St. machar drive 23 AB2 IRY Aberdeen See on map UNIVERSITY OF UPPSALA Sweden EU contribution € 0,00 Address P.o. box 582 751 23 Uppsala See on map Université de Paris VI (Université Pierre et Marie Curie) France EU contribution € 0,00 Address 9 quai saint bernard 75230 Paris See on map
