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FISH PROTECTION IN AQUACULTURE : IMPROVEMENT OF VACCINE EFFICACY BY STUDYING STIMULATION OF THE FISH IMMUNE RESPONSE

Objective



This project will focus on the stimulation of a protective immune response in fish, the understanding of the mechanisms involved and further the ability to design optimal vaccines allowing a high protective immunity. Two fish species will be studied: salmonids (rainbow trout, Oncorhyncus mykiss, and salmon, Salmo salar) and cypronids (carp, Cyprinus carpio L.), and immune stimulation will be performed with two viral pathogens: the SVC virus (Spring Viremia of Carp) and the VHS virus (Viral Haemorrhagic Septicemia) infecting salmonids. We will use in particular a well characterized antigen from these viruses, the G protein which will be produced in microorganisms and purified.

The stimulation of a protective immune response is divided into various essential steps that requires multi-disciplinary analysis: antibody production, antigen presentation, B-cells stimulation and T-cells functions, cytotoxicity, and cytokine-mediated response. These studies will lead to the determination of the best immunisation and design of optimal immunogens for fish vaccination.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

SOCIETE EUROPEENNE DE BIOTECHNOLOGIE S.A.
Address
Rue Bois Saint Jean 14
4102 Seraing
Belgium

Participants (6)

AGRICULTURAL UNIVERSITY OF WAGENINGEN
Netherlands
Address
Postbus 9101
6700 HB Wageningen
INIA
Spain
Address
Apartado De Correos 8111
28040 Valdeolmos
UNIVERSITE DE LIEGE
Belgium
Address
Place Du 20-Aout 7
4000 Liege
UNIVERSITY OF ABERDEEN
United Kingdom
Address
St. Machar Drive 23
AB2 IRY Aberdeen
UNIVERSITY OF UPPSALA
Sweden
Address
P.o. Box 582
751 23 Uppsala
Université de Paris VI (Université Pierre et Marie Curie)
France
Address
9 Quai Saint Bernard
75230 Paris