FISH PROTECTION IN AQUACULTURE : IMPROVEMENT OF VACCINE EFFICACY BY STUDYING STIMULATION OF THE FISH IMMUNE RESPONSE

Objective

This project will focus on the stimulation of a protective immune response in fish, the understanding of the mechanisms involved and further the ability to design optimal vaccines allowing a high protective immunity. Two fish species will be studied: salmonids (rainbow trout, Oncorhyncus mykiss, and salmon, Salmo salar) and cypronids (carp, Cyprinus carpio L.), and immune stimulation will be performed with two viral pathogens: the SVC virus (Spring Viremia of Carp) and the VHS virus (Viral Haemorrhagic Septicemia) infecting salmonids. We will use in particular a well characterized antigen from these viruses, the G protein which will be produced in microorganisms and purified.

The stimulation of a protective immune response is divided into various essential steps that requires multi-disciplinary analysis: antibody production, antigen presentation, B-cells stimulation and T-cells functions, cytotoxicity, and cytokine-mediated response. These studies will lead to the determination of the best immunisation and design of optimal immunogens for fish vaccination.

Programme(s)

• FP3-AIR - Specific research and technological development and demonstration programme (EEC) in the field of agriculture and agro-industry, including fisheries, 1990-1994

Topic(s)

• 251 - Health of aquacultural stocks

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

SOCIETE EUROPEENNE DE BIOTECHNOLOGIE S.A.

Address

Rue Bois Saint Jean 14
4102 Seraing
Belgium

 

Participants (6)

AGRICULTURAL UNIVERSITY OF WAGENINGEN

Netherlands

Address

Postbus 9101
6700 HB Wageningen

 

INIA

Spain

Address

Apartado De Correos 8111
28040 Valdeolmos

 

UNIVERSITE DE LIEGE

Belgium

Address

Place Du 20-Aout 7
4000 Liege

 

UNIVERSITY OF ABERDEEN

United Kingdom

Address

St. Machar Drive 23
AB2 IRY Aberdeen

 

UNIVERSITY OF UPPSALA

Sweden

Address

P.o. Box 582
751 23 Uppsala

 

Université de Paris VI (Université Pierre et Marie Curie)

France

Address

9 Quai Saint Bernard
75230 Paris