Objective OBTAIN COMPLEX ANTIGENS ALLOWING THE DEVELOPMENT OF IMMUNITY AGAINST FOOT AND MOUTH DISEASE VIRUS, AND MAYBE OBTENTION OF A SAFE AND CHEAPER VACCINE AGAINST FOOT AND MOUTH DISEASE. The project aimed at the synthesis in baker's yeast of a hybrid virus like particle comprising the surface antigen of the virus which caused hepatitis B in man, and part of a surface protein from foot and mouth disease virus (FMDV). Many yeast strains were genetically engineered by recombinant deoxyribonucleic acid (DNA) techniques, producing hybrid virus like particles in which the FMDV portion was present at different sites. It is hoped that these studies will shed light on the question of which parts of the FMDV are essential and how they must be presented to the immune system, in order to protect target animals against the disease.THE OBJECTIVE OF THE PROGRAMME IS TO DEVELOP A HIGHLY IMMUNOGENIC COMPLEX CONTAINING FMDV ANTIGENIC DETERMINANTS AGAINST DIFFERENT TYPES OF THE VIRUS. THE POLYVALENT SUB-UNIT VACCINE WILL BE PRODUCED BY RECOMBINANT DNA TECHNIQUES, ASSOCIATING FMVD ANTIGENIC DETERMINANTS WITH HEPATITIS B SURFACE ANTIGENS. THESE RECOMBINANT PARTICLES WILL BE EXPRESSED IN YEAST OR ANIMAL CELLS, AND ANALYZED FOR THEIR IMMUNOLOGICAL PROPERTIES. Fields of science natural sciencesbiological sciencesmicrobiologyvirologynatural sciencesbiological sciencesgeneticsDNAmedical and health scienceshealth sciencesinfectious diseasesmedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP1-BAP - Multiannual research action programme (EEC) in the field of biotechnology (BAP), 1985-1989 Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator University of Edinburgh Address King's buildings mayfield road EH9 3JR Edinburgh United Kingdom See on map EU contribution € 0,00 Participants (2) Sort alphabetically Sort by EU Contribution Expand all Collapse all TNO Netherlands EU contribution € 0,00 Address Rijswijk See on map Wellcome Biotechnology United Kingdom EU contribution € 0,00 Address GU21 Woking See on map
