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HEPATITIS B SURFACE ANTIGEN PARTICLE AS A CARRIER FOR PRESENTATION OF FOOT AND MOUTH DISEASE VIRUS ANTIGENS

Objective

OBTAIN COMPLEX ANTIGENS ALLOWING THE DEVELOPMENT OF IMMUNITY AGAINST FOOT AND MOUTH DISEASE VIRUS, AND MAYBE OBTENTION OF A SAFE AND CHEAPER VACCINE AGAINST FOOT AND MOUTH DISEASE.
The project aimed at the synthesis in baker's yeast of a hybrid virus like particle comprising the surface antigen of the virus which caused hepatitis B in man, and part of a surface protein from foot and mouth disease virus (FMDV). Many yeast strains were genetically engineered by recombinant deoxyribonucleic acid (DNA) techniques, producing hybrid virus like particles in which the FMDV portion was present at different sites. It is hoped that these studies will shed light on the question of which parts of the FMDV are essential and how they must be presented to the immune system, in order to protect target animals against the disease.
THE OBJECTIVE OF THE PROGRAMME IS TO DEVELOP A HIGHLY IMMUNOGENIC COMPLEX CONTAINING FMDV ANTIGENIC DETERMINANTS AGAINST DIFFERENT TYPES OF THE VIRUS. THE POLYVALENT SUB-UNIT VACCINE WILL BE PRODUCED BY RECOMBINANT DNA TECHNIQUES, ASSOCIATING FMVD ANTIGENIC DETERMINANTS WITH HEPATITIS B SURFACE ANTIGENS. THESE RECOMBINANT PARTICLES WILL BE EXPRESSED IN YEAST OR ANIMAL CELLS, AND ANALYZED FOR THEIR IMMUNOLOGICAL PROPERTIES.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

University of Edinburgh
Address
King's Buildings Mayfield Road
EH9 3JR Edinburgh
United Kingdom

Participants (2)

TNO
Netherlands
Address

Rijswijk
Wellcome Biotechnology
United Kingdom
Address

GU21 Woking