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LOCAL RETENTION AND TRANSLOCATION OF PARTICLES IN THE RESPIATORY TRACT

Objective

PROJECT 1: MECHANISMS GOVERNING PARTICLE TRANSLOCATION AND RELATED ASPECTS OF LUNG FUNCTION.
THE PRIMARY AIM IS TO CLARIFY THOSE CELLULAR AND PHYSIOLOGICAL PROCESSES WHICH DETERMINE THE MOVEMENT OF PARTICLES WITHIN THE RESPIRATORY TRACT, ESPECIALLY TO SITES WHICH ARE IMPORTANT IN LUNG DOSIMETRY.

PROJECT 2: SPATIAL DISTRIBUTION OF PARTICLES IN THE LUNG IN RELATION TO CELLS AT RISK.
THE AIM IS TO MAKE A QUANTITATIVE ASSESSMENT OF THE ACTUAL SPATIAL DISTRIBUTION OF PARTICLES AT LONG TIMES AFTER INHALATION.
Mechanisms governing particle translocation and related aspects of lung function have been studied as has the spatial distribution of particles in the lung in relation to cells at risk. The data from the short term studies confirm that the microinjection technique results in a pattern of deposition where nearly all of the particles are in subpleural alveoli, with a small proportion in alveoli a few hundred micrometres deeper into the lung, but withno deposition on any of the ciliated airways. Hence it is possible by this technique to study clearance specifically from the alveolar region of the lung and to study the movement of particles resolved over quite small distances within the lung.
1. MECHANISMS GOVERNING PARTICLE TRANSLOCATION AND RELATED ASPECTS OF LUNG FUNCTION.
2. SPATIAL DISTRIBUTION OF PARTICLES IN THE LUNG IN RELATION TO CELLS AT RISK.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

Medical Research Council (MRC)
Address
20 Park Crescent
W1N 4AL London
United Kingdom