European Commission logo
English English
CORDIS - EU research results
CORDIS
Content archived on 2024-04-15

PATHOGENESIS OF LATE SOMATIC EFFECTS OF RADIATION

Objective

EVALUATION OF RISKS FROM RADIATION-INDUCED CANCER.
MECHANISMS AND RISKS OF BONE CANCER FROM INCORPORATED RADIONUCLIDES.
The activation of proviral genes and their interaction with cellular oncogenes, in radiation carcinogenesis, was studied by 2 approaches.
First, the activation of endogenous retroviruses during the early latent period of radiation induced osteosarcomagenesis, as well as in induced tumours, and the pathogenicity of various virus isolates was studied in different mouse strains. Radiation induced osteosarcomas were investigated for retrovirus and protooncogene rearrangement and amplification.
Second, cell and tissue culture models were applied to establish the molecular and morphological events during normal osteogenic differentiation and to characterise retrovirus and oncogen induced effects on skeletal cells in vitro.
1. RADIATION-INDUCED ONCOGENESIS UNDER DIFFERENT EXPOSURE CONDITIONS.
2. PATHOGENESIS OF RADIATION-INDUCED CANCER.

Topic(s)

Data not available

Call for proposal

Data not available

Coordinator

GSF - FORSCHUNGSZENTRUM FUER UMWELT UND GESUNDHEIT GMBH
EU contribution
No data
Address
Ingolstaedter Landstrasse 1
85764 NEUHERBERG
Germany

See on map

Links
Total cost
No data