EVALUATION OF RISKS FROM RADIATION-INDUCED CANCER.
MECHANISMS AND RISKS OF BONE CANCER FROM INCORPORATED RADIONUCLIDES.
The activation of proviral genes and their interaction with cellular oncogenes, in radiation carcinogenesis, was studied by 2 approaches.
First, the activation of endogenous retroviruses during the early latent period of radiation induced osteosarcomagenesis, as well as in induced tumours, and the pathogenicity of various virus isolates was studied in different mouse strains. Radiation induced osteosarcomas were investigated for retrovirus and protooncogene rearrangement and amplification.
Second, cell and tissue culture models were applied to establish the molecular and morphological events during normal osteogenic differentiation and to characterise retrovirus and oncogen induced effects on skeletal cells in vitro.
1. RADIATION-INDUCED ONCOGENESIS UNDER DIFFERENT EXPOSURE CONDITIONS.
2. PATHOGENESIS OF RADIATION-INDUCED CANCER.