Objective
DEVELOPMENT OF THE MICRONUCLEUS TEST AND THE MICROCOLONY ASSAY SYSTEM FOR ANALYSIS OF GENETIC DAMAGE IN CELLS TREATED WITH EITHER IONIZING RADIATIONS OR ENVIRONMENTAL CHEMICALS. DIFFERENTIATION OF THE CONTRIBUTIONS OF 1-TRACK AND 2-TRACK EVENTS IN MORPHOLOGICAL ALTERATIONS OF NUCLEAR CHROMATIN EXPOSED TO CHARGED PARTICLES.ANALYSIS OF RBE COMPONENTS (LOW ENERGETIC ALPHA PARTICLES) ACCORDING TO 1-TRACK-1-BREAK, 1-TRACK-2-BREAK AND 2-TRACK EVENTS IN MAMMALIAN CELL SYSTEMS. INFLUENCE OF REPAIR OF POTENTIALLY LETHAL DAMAGE ON THESE RBE COMPONENTS.
PREVENTION OF REPAIR OF PRECHROMOSOMAL LESIONS BY PREMATURE CHROMOSOME CONDENSATION (PCC-) TECHNIQUE. DEVELOPMENT OF A NEW METHOD TO INDUCE PCC BY ELECTROFUSION. DETAILED ANALYSIS OF THE PREREQUISITES TO GENERATE CELL HYBRIDS FROM IRRADIATED G1-CELL CULTURES AND M-PHASE CULTURES. OPTIMIZATION OF THE TIMING OF ELECTROFUSION ACCORDING TO THE AIM TO PREVENT REPAIR. ANALYSIS OF CHROMOSOME DAMAGE IN PCC INDUCED MITOSIS IN DEPENDENCE ON THE TIME BETWEEN IRRADIATION AND FIXATION (REPAIR KINETICS). APPLICATION OF ELECTROFUSION-PCC TO TREATMENT WITH CERTAIN ENVIRONMENTAL CHEMICALS (NOT YET DETERMINED IN DETAIL) IN ORDER TO INCREASE SENSITIVITY OF DOSE RESPONSE. COMPARISON OF DOSE RESPONSE RESULTING FROM GENETIC DAMAGE WITH DOSE RESPONSE RESULTING FROM MEMBRANE DAMAGE ACCORDING TO ADDITIONAL DATA FROM CELL ROTATION IN AN ALTERNATING FIELD OF HIGH FREQUENCY (ZIMMERMANN METHOD).
INFLUENCE OF GLUTATHIONE (GSH) AND OTHER NON-PROTEIN BOUND SH CELL COMPONENTS ON REPAIR OF PRECHROMOSOMAL LESIONS INDUCED BY EITHER IRRADIATION OF ENVIRONMENTAL CHEMICALS. INVESTIGATION OF GSH DEPLETION ON REPAIR PERFORMANCE AND REVERSION OF THIS EFFECT AFTER INCORPORATION OF NPSH COMPONENTS ADDED TO THE GROWTH MEDIUM .. APPLICATION OF THE ELECTROFUSION TECHNIQUE TO INCREASE THE PLASMA MEMBRANE PERMEABILITY TO CERTAIN THIOLS AND ENZYMES (EVENTUALLY COOPERATION WITH DR P BRYANT, UNIVERSITY OF ST ANDREWS, SCOTLAND) .
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences nuclear physics
- natural sciences earth and related environmental sciences environmental sciences pollution
- natural sciences biological sciences genetics chromosomes
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
85764 NEUHERBERG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.