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GENETIC CHANGES IN MAMMALIAN CELLS FOLLOWING HEAVY ION IRRADIATION

Objective


Radiation induced delays in cell cycle progression have been measured for alpha particles and heavy ion beams using asynchronous cell populations. These measurements, using cytofluorometric methods, show partially contradictory results and are difficult to correlate with measurements of cell cycle delay using the mitotic index or PLM methods. An interpretation of these experiments is difficult because they were performed with asynchronous cell populations. In this case, the measured deoxyribonuceic acid (DNA) spectra were only sensitive to relative changes within the population of the cell cycle phases. A simultaneous slowing down of all cells in all phases does not change the relative proportion of cells in different phases and therefore cannot be detected using this method.
1. MEASUREMENT OF CHROMOSOMAL ABERRATIONS IN MAMMALIAN CELLS INDUCED BY A WIDE VARIETY OF DIFFERENT RADIATION QUALITIES INCLUDING ULTRA DENSELY IONIZING HEAVY CHARGED PARTICLES.
EXPECTED BENEFITS

EVALUATION OF GENETIC RISKS FROM IONIZING RADIATION. DETERMINATION OF GENETIC DAMAGE IN MAN ON THE BASIS OF CHROMOSOME ABERRATIONS INDUCED BY HIGH LET RADIATION.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

GESELLSCHAFT FUER SCHWERIONENFORSCHUNG MBH.
Address
Planckstrasse 1
Darmstadt
Germany