Objective
Oxygen radicals may be responsible, not only for induction of cancer, but also for other degenerative diseases and for ageing. The formation of endogenous oxygen radicals, on the other hand, is an unavoidable natural process. Hydroxyl radicals are generated by ionising radiation. Since it has been demonstrated that exposure to low doses of some mutagens are protective for the cells when they are posttreated with higher doses (adaptive response) it is worth studying the response to ionising radiation after exposure to hydrogen peroxide.
Human lymphocytes pretreated with low doses of ionising radiation either from incorporated tritium or from X-rays become less susceptible to the chromosome damage induced by a subsequent irradiation with a higher dose of X-rays. This phenomenon is reminiscent of the adaptive response to alkylation damage reported in Escherichia coli. The response to alkylating agents, however, is known to be related to the induction of an alkyltransferase which cannot be responsible for the repair of radiation damage. For radiation protection, a good knowledge of the levels of exposure of human population to ionising radiation as well as the response of individuals to a given dose is necessary. Also, exposure of cells to low doses of mutagens deserves special attention because it probably more appropriately reflects the situation in natural environments.
Peroxides yield transient radical species that can damage deoxyribonucleic acid (DNA). Such partially reduced oxygen species are also generated by lethal ionising radiation and mutagenic ionising radiation. Low doses of hydrogen peroxide reduces the sensitivity of E. coli to a subsequent exposure to hydrogen peroxide or gamma-rays. Our results show the adaptive response after a single 30 minute pulse with hydrogen peroxide. The conditioning doses induced only a low frequency of aberrations. It therefore appears that low levels ofoxidative radicals that are produced by hydrogen peroxide, and migh t also be induced in water by low doses of X-rays, can induce the adaptive response in human cells. On the other hand, an explanation for the lack of adaptive response when the cells received multiple pulses with hydrogen peroxide prior to X-rays is not at hand, though the easiest explanation could be that the adaptive response becomes saturated after multiple conditioning insults.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics chromosomes
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Data not available
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
41012 SEVILLA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.