Objective
Superior enantioselectivity is an important driving force for the proliferation of enzymes in industrial biotransformations. However, on expanding the scope of enzymatic conversions to organic media substantial deviations from the intrinsic selectivity in aqueous solution have been observed. Ambiguous enantioselective behaviour of enzymes in organic solvents frustrates their use as customised catalysts in industrial processes. Since current attempts to establish (semi-) empirical correlations of enzyme enantioselectivity with bulk solvent properties turn out to be of limited value, fundamental studies are required.
Main objective of this project is the understanding of medium effects on enzyme enantioselectivity. Our strategy involves the rigorous evaluation of mechanistic, kinetic, and thermodynamic contributions that may affect the enantioselective performance of lipases from Rhizomucor miehei and Candida antarctica in kinetic resolutions and asymmetrizations of chiral and prochiral alcohols and acids in organic media. R. miehei and C. antarctica lipases are versatile catalysts with great industrial potential. Extensive structural information is available for both enzymes. Judicious combination of dynamic and structural knowledge will provide a frame of reference against which molecular modelling techniques can be properly validated. By performing convergent mechanistic, thermodynamic and molecular modelling investigations on a limited set of targets, the participating groups expect to gain insight that will open novel perspectives for the rational design of medium-engineering tools applicable to a broad range of enzyme-catalysed kinetic resolutions of industrial interest.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences organic chemistry alcohols
- natural sciences chemical sciences catalysis
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
2628 BC Delft
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.