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Improvement of electrochemical response, stability and selectivity of reagentless, miniaturised, screen printable, organic phase enzyme sensor arrays

Objective



The use of sensors to detect, monitor and quantitate substances or processes offers a convenient and rapid methodology ideally suited to modern day requirements and easily interfaced to computers for control and data processing. The main drawback in the use of sensors is the level of confidence in the sensors themselves, as parameters such as stability, reproducibility and manufacturability have not been adequately overcome for many types of sensors. In particular biosensors, which offer some of the most exciting developments in interfacing biology with electronics, suffer from instability and in consequence the quality of results can be highly variable. The main goals of the research project proposed for section 6.2 of the Biotechnology programme (Interfacing biology with electronics) is to gain understanding of the mechanisms of the instability of the biological molecules in biosensor matrices and the interactions ocurring between the biological molecules and the electroconductive surfaces or the sensor device which affect the electrochemistry, stability and selectivity of the biosensors produced. The knowledge gained will be used to develop methods of manufacture of biosensors having acceptable stability and electrochemical characteristics leading to reproducibility or response, quality of results, reproducibility in manufacture and simplicity of use. In addition the knowledge gained in this project may be applicable to biology - electronic interface technology other than sensors eg. biological memory devices, switches, solar collection devices using biologicals and energy tranducers.

Funding Scheme

EAW - Exploratory awards

Coordinator

Applied Enzyme Technology Limited
Address
Woodhouse Lane
LS2 3AR Leeds
United Kingdom

Participants (1)

Trace Analysensysteme GmbH
Germany
Address
1B,mascheroder Weg 1B
38100 Braunschweig