Integrated protein sequence database

Objective

Meeting the demands of academic and industrial users for a comprehensive protein sequence database while realizing the potential implicit in the emerging information highway will require the development and adoption of new technologies. Areas of particular concern include:
- database integration through the combination of sequence databases with exogenous data generated by external sources (in this case abstracts, gene mapping data, genomic sequence data, protein structure data, complex carbohydrate data, etc.)
- application of new database technologies to ease access to sequence and related data
- intuitive user-interfaces and database access tools
- reliable, synchronized, real-time data distribution strategies These areas have been designated in section 8.1.1 in the call for proposals to the FRAMEWORK IV programme as those specifically in need of increased attention and developmental efforts. We propose to meet these new challenges by the adoption of object-oriented database technologies and by the utilization of advanced, self-synchronizing, data distribution protocols. Industrial and academic sites will actively participate in the development of a common, coherent framework to ensure a user-oriented approach. The proposed work will focus on the following initiatives:
- rapid collection and annotation of protein sequence data
- organization of the protein sequence database into multiple, object-oriented components
- organization of a continuously updated database of protein families and multiple alignments
- integration of protein and nucleic sequence data and other exogenous data within a comprehensive, query-oriented database and information retrieval system
- synchronization of remote database copies at the participants' sites - development of a flexible user-oriented interface to satisfy the needs as identified in close collaboration with the academic and industrial partners - development of an integrated, versatile, and comprehensive sequence database system as a self-supporting, market-oriented product The project will emphasize to the vital interaction of the database producer and the academic/industrial database users.

Programme(s)

• FP4-BIOTECH 2 - Specific research, technological development and demonstration programme in the field of biotechnology, 1994-1998

Topic(s)

• 080101 - Information resources on molecular sequences and structures

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

Address

Am Klopferspitz 18 A
82152 Martinsried
Germany

Participants (4)

Böhringer Mannheim GmbH

Germany

Address

2,Nonnenwald
82377 Penzberg

Institut Pasteur

France

Address

28,Rue Du Docteur Roux
75724 Paris

Pfizer Ltd

United Kingdom

Address

Ramsgate Road
CT13 9NJ Sandwich

UNILEVER NEDERLAND BV

Netherlands

Address

120,Olivier Van Noortlaan 120
3133 AT Vlaardingen