Objective
The human genome encodes about 100000 different proteins. As a result of genome sequencing projects the sequences of nearly all of these will be known (from cDNAs) by about 1997 or 1998. For only about 500 human proteins are 3D coordinates known, and this number only grows slowly. The imbalance between these two types of knowledge can be reduced considerably by making use of the technique of homology modelling. At the moment, about one in six new eukaryotic sequences can be modelled , and we can therefore confidently estimate that about 20000 models can be built by 1998.
The goals of the project are:
- development of tools to produce reliable structural models of proteins from genetic sequence data using the technique of homology modelling; - improvement of both statistical and physical modelling methods to assure the highest possible quality of the models;
- modelling about 20000 human proteins from genome-derived sequences; - the public availability of these models and the model building tools to European researchers and educators as a service over Internet; - provision of viewing and analysis software for personal computers and workstations to assure the widest possible dissemination of knowledge about three-dimensional structures of human proteins.
The modelling servers will be freely available not only to academic but also to industrial users. One of the servers will guarantee complete confidentiality for those that require it. Synergistic effects are anticipated with other European projects, such as the planned European branch of the PDB, the SRS project of linking databases, and projects aimed at linking human genome databases, such as IGD.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences software
- natural sciences computer and information sciences internet
- natural sciences computer and information sciences databases
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics genomes
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
HEIDELBERG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.