Objective
G protein coupled receptors (GPCRs) are the targetin the human body for most of today's medicines. Almost all European pharmaceutical companies market GPCR agonists or antagonists as drugs aimed at diverse disease states such as hypertension, sleeplessness, anxiety anddepression. The introduction of rational drug design has greatly enhanced the importance of fast and flexible access to data of different origins. Many different databases are queried routinely by academic and industrial scientists in the GPCR field. It would be a significant step forward in the rational drug design process if all existing GPCR related data were to reside in one well annotated, integrated database that could be queried in an intelligent manner.
The goals of the proposed grant are:
- Gathering data related to all aspects of G protein coupled receptors;
- Verification of data quality and consistency;
- Annotation of individual data items;
- Storage of all heterogeneous data in an object oriented database;
- Design of intelligent query systems and data-based inference engines;
- Automation of the first four items.
The participants will pursue these goals and combine the results in a database system that can be queried openly via computer networks.
The innovation potential of this project is greatest for the rational design of drugs. Pharmaceutical industries will use this database during the design cycle (lead finding - lead optimisation drug optimisation) of new and better medicines. Four European companies have made a commitment to function as beta-testers during the development of the system.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences databases
- medical and health sciences basic medicine medicinal chemistry
- natural sciences biological sciences biochemistry biomolecules proteins
- social sciences sociology industrial relations automation
- engineering and technology electrical engineering, electronic engineering, information engineering information engineering telecommunications telecommunications networks
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
HEIDELBERG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.