Objective
This proposal, which was initiated by the eight members of a HCM-funded network on gene silencing, combines fourteen European laboratories to elucidate the mechanisms of gene silencing in plants. The aims of the project are to control the expression of recombinant constructs in transgenic plants and to employ silencing as a new approach for controlled gene repression.
The project comprises three major objectives:
1. To identify the structural and context- specific requirements for stable expression of transgenes.
2. To understand and exploit silencing of endogenous genes after introduction of transgenic homologues.
3. To define environmental and physiological conditions that favour stable transgene activity.
All of the partner laboratories involved in the proposal, represent experts for individual aspects of gene silencing research, with the appropriate research facilities and technical expertise. However, it is highly unlikely that the objectives of this proposal can be accomplished by the work of individual laboratories, which was the reason to initiate a trans-national and interdisciplinary research programme. Experiences from the HCM-network have demonstrated the importance of regular contacts among the participants, as these have helped to identify common silencing mechanisms for the different experimental systems. Due to the feedback gained from public presentation of the network activities, new partner labs have been identified that complement that research approaches. Based on these experiences, the participants of this proposal have defined three major tasks for this proposal:
1. The combination of several expert laboratories to address specific aspects of the objectives mentioned above.
2. The establishment of a management structure that allow a continuous and efficient exchange of data, material and ideas.
3. The continuation of regular public presentations that guarantee an efficient dissemination of results, in order to bridge the gap between basic science and industry.
With gene silencing research currently being a European domain, the project should make significant contributions to improve the control and quality of transgene technology and its application in Europe.
Fields of science (EuroSciVoc)
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LS2 9JT LEEDS
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.