Objective
THE PRIMARY OBJECTIVE OF THIS PROJECT IS TO CONTRIBUTE TO THE COMPLETION OF THE GENOME SEQUENCE OF THE ARCHAEAL HYPERTHERMOPHILE SULFOLOBUS SOLFATARICUS. THIS PROJECT WAS STARTED IN 1993 BY THREE CANADIAN LABORATORIES SPONSORED BY THE CANADIAN NATIONAL RESEARCH COUNCIL. 25% OF THE 3 MBP GENOME HAS BEEN SEQUENCED AND ABOUT ONE THIRD WILL BE COMPLETED WHEN THEIR 3 YEAR GRANT TERMINATES IN SUMMER 1996. THEY HAVE BEEN PROMISED A THREE YEAR RENEWAL, AT THE SAME FINANCIAL RATE AS BEFORE, WHICH MEANS THAT THEY WILL HAVE SEQUENCED TWO-THIRDS OF THE GENOME BY THE END OF 1999.
WE ARE THREE EUROPEAN UNIVERSITY LABORATORIES AND ONE INDUSTRIAL LABORATORY WHO HAVE NEGOTIATED WITH THE CANADIAN GROUPS THAT WE WILL SEQUENCE THE REMAINING ONE THIRD OF THE GENOME. THE CANADIANS HAVE A LINEAR COSMID LIBRARY COVERING ALMOST THE WHOLE GENOME AND THEY WILL PROVIDE US WITH COSMIDS COVERING ABOUT ONE THIRD OF THE GENOME.
THE THREE EUROPEAN UNIVERSITY LABORATORIES WILL PERFORM SUB-CLONING AND SEQUENCING AND NOVO-NORDISK A/S WILL HELP BOTH WITH PROCESSING OF THE SEQUENCING DATA AND WITH DEVELOPING SOFTWARE FOR ACCESSING REGULATORY SIGNALS, MOTIFS AND CODING REGIONS IN THE GENOME SEQUENCES WHICH ARE OF POTENTIAL INDUSTRIAL INTEREST; THESE THEY WILL MAKE AVAILABLE TO THE INDUSTRIAL PLATFORM. THE NEW SEQUENCES WILL BE EXCHANGED WITH THE CANADIANS AND MADE AVAILABLE, AS QUICKLY AS POSSIBLE (WITHIN A FEW MONTHS), TO UNIVERSITY AND INDUSTRIAL LABORATORIES WORKING ON ARCHAEAL HYPERTHERMOPHILES AND THERMOSTABLE GENE PRODUCTS. IN PARTICULAR, THEY WILL BE MADE AVAILABLE TO OTHER LABORATORIES WORKING ON EU CELL FACTORY PROGRAMS CONCERNED WITH THERMOPHILIC ORGANISMS. WE PLAN TO COMPLETE THE S. SOLFATARICUS GENOME, WHICH IS OF CONSIDERABLE INTEREST TO INDUSTRY BECAUSE OF THE THERMOSTABLE NATURE OF ALL ITS ENZYMES, AS A JOINT EUROPEAN CANADIAN EFFORT BY THE END OF THE THREE YEAR PROGRAM IN DECEMBER 1999.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences software
- natural sciences biological sciences genetics genomes
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1307 København K
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.