Objective
The proposed project is aimed at the improvement of the sensitivity and effectiveness of immunoassays by using DNA-labelled antibodies in combination with a novel electrochemical nucleic acid quantification system. Antibody-based detection and in-vitro DNA amplification together constitute a system that unifies two revolutionary methods of modern biotechnology. Amplification of antibody-born DNA-labels by PCR or isothermal transcription enhances the signal by several magnitudes of order compared with commonly used enzyme- or radio-isotype labels. The project's main emphasis is on the development of a novel mination of the amplification products. The detection principle is based on the hybridization of the products with single stranded DNA probes which are immobilised onto a microchip electrode array. The double stranded nucleic acid hybrids are detected by measuring the electrochemical signals derived from an electrochemical active intercalator which binds only to double stranded molecules. Since the hybridization reaction is sequence selective, it is possible to detect multiple analytes by using a microchip electrode with single addressable electrodes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules nucleic acids
- natural sciences biological sciences genetics DNA
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
48161 Münster
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.