Objective
Stakes:
Availability of adequate test model systems is essential to the development of a product safety assessment programme. The need of accurate predictive in-vitro models of toxicity in humans, alternative to the use of intact animals, is becoming an imperative research priority in the actual scientific and industrial context.
Goal:
The objective of the present project is to develop novel 3D in-vitro models of human tissues from five major target organs for Pharmaco-Toxicology: liver and colon (digestive system), ovary and testis (reproductive system), Skin and annexes.
Work content:
This objective will be pursued by a Work Programme which allies an integrated scientific approach to an innovative technology: the 3D-culture device, known as "Rotating Wall Vessel".
Our strategy is planned around 5 main points which include, beside the use of RWV technology, multiple cell cultures' quality controls, immortalization control, cell banking and the use of specific markers of cell differentiation/health, in order to obtain 3D-cultures of differentiated human cells.
Expected Results and Related Benefits:
The corresponding work programme will be ensured by an important involvement of the whole partnership and by a high degree of coordination. The expected results of our effort will be either scientifically, or economical relevant: 1) the assessment of an innovative technology for organotypic cell cultures; 2) the constitution of a cell bank and, finally, 3) a battery of human-derived differentiated in-vitro systems for basic and applied research (e.g. toxicology) and industrial use. The economical relevance of our project i attested by the importance of industrial participation.
Partnership:
Four industry representatives, two big companies and two SME from different fie (Pharmaceuticals, Cosmetics, General Toxicology and Technology supplies), join effort to that of public organizations orientated in health care research and education, to achieve the proposed objective.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- medical and health sciences basic medicine toxicology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
78352 Jouy-en-Josas
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.