Objective
Progression of solid tumours is accompanied by proliferation of newly-formed blood vessels ('neo-vascuLature"), which supply the rapidly growing tumour cells with nutrients. Although present also in wound healing and fetal development, neovasculature formation is a characteristic feature of tumour growth.
Neo-vasculature markers are thought to be among the best goals for tumour targeting therapeutic strategies. Optimal neo-vasculature markers have the following desirable characteristics: a) they are expressed in reasonably large quantity only by newly formed blood vessels b) they are expressed by neo-vasculature of a large variety of different tumours, and thus represent multi-purpose targets for several anti-cancer applications c) they are readily accessible to targeting agents, for example specific monoclonal antibodies labeled with a radionuclide, allowing a fast and specific delivery of toxic agents which may impair tumour cells viability.
Neo-vasculature markers of excellent quality have recently been described by one of the Participants of our Project (Castellani, P., Viale, G., Dorcaratto, A., Nicolo, G., Kaczmarek, J., Querze, G. and Zardi, L. (1994) Int. J. Cancer 59, 612-618).
The objectives of this Project are:
1) Isolate endothelial cells from human tumours.
2) Use the most advanced technologies in phenotype analysis such as computerised 2Dpolyacrylamide gel electrophoresis (2D-PAGE) and selection with antibody phage display libraries to identify novel good neo-vasculature markers and to evaluate their variability from patient to patient.
3) Produce high-affinity recombinant antibodies against neo-vascuLature markers using phage display technology.
4) Evaluate the performance of anti-neo-vasculature antibodies in immunocytochemistry and in vivo tumour targeting, setting the basis for their use in diagnosis and therapy.
The identification of good neo-vasculature markers and the production of high-affinity recombinant antibodies directed against them is of considerable industrial interest for the reasons outlined above. We believe to have the expertise to deliver all the three objectives of the program.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- medical and health sciences clinical medicine obstetrics fetal medicine
- medical and health sciences clinical medicine oncology
- natural sciences chemical sciences electrochemistry electrophoresis
- natural sciences chemical sciences nuclear chemistry radiation chemistry
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
53100 SIENA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.