Objective
Neurodegenerative diseases, like Alzheimer's, Parkinson's or Huntington's diseases, constitute a major health problem in Europe. There are no therapies for these diseases except in the case of Parkinson's disease where current pharmcological treatment can limit for a time the evolution of the symptoms. However, some neurotrophic factors have been identified as drug candidates. Neurotech's core technology is based on the use of brain endothelial cell lines as cellular vectors for drug delivery to the CNS. Accordingly, the present programme is focused on the production of gentically engineered brain endothelial cell lines secreting neurotrophic factors under the control of viral or housekeeping gene promotors identified by NeuroSearch. The therapeutic efficacy of these cell lines will be evaluated by cerebral transplantation in rats with experimentally induced neurodegenerative diseases. Among the criteria assessed will be the survival of susceptible neuronal populations and the improvement in animal behavior at various times after transplantation. As a therapeutic approach of neural transplantation in Parkinson's disease, the feasibility of grafting human fetal neurons is now clinically well established. However, this strategy, dependant on a constant supply of human fetal tissues, raises important ehtical and practical issues. Alternatively, the present programme, based on the use of stable cerebral endotherlial cell lines, could contribute to the further development of a novel therapeutic strategy for neurogenerative diseases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- medical and health sciences basic medicine neurology dementia alzheimer
- medical and health sciences medical biotechnology genetic engineering gene therapy
- medical and health sciences basic medicine neurology parkinson
- medical and health sciences clinical medicine transplantation
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75015 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.