Objective
Development of a anti-tumor therapy based on biotechnological engineering of plasmoviruses expressing Apoptin. The two SME companies Genopoietic/Sarl and Leadd bv are both active in the biotechnology field of the (human) gene therapy. Leadd bv developed a very strong and specific anti-tumor agent, named Apoptin. Apoptin induces specifically apoptosis (programmed cell death) in human tumor cells, but not in normal cells. Under circumstance, several chemotherapeutics could not induce apoptosis, Apoptin was proven to do so. Genopoietic/Sarl has developed a potent and safe gene-therapy vectors is easy to produce in large quantity as clinical grade materials and allow efficient and safe in vivo targeting for tumor cells. Plasmoviruses will be developed, which express Apoptin at high levels. In vitro, as well as, in-vivo studies will be carried out to optimize the efficacy of induction of appoptosis in tumor cells by plasmovirus-expressed Apoptin. Tumor regression and the effect on normal cells will be studies. The final goal will be to develop a anti-tumor protocol based on plamoviruses expressing anti-tumor agent Apoptin that is safe and accurate.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
2300 RA LEIDEN
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.