Objective
The proposed project concerns a new approach to drug therapy, gene regulatory DNA-binding drugs. Such agents are conceived to modify disease processes by altering the expression of the genes associated with them. The envisaged molecular mechanism of action involves the displacement of an appropriate transcription factor from the promoter region of the target gene by a low molecular weight(<1000Da) sequence-sepcific DNA-binding compound. Potential applications exist in the treatment of viral infections, cancer, and various other diseases. The proposed research will result in the development of a library of sequence-specific DNA-binding molecular fragment, which will comprise the building blocks from which the gene-regulatory drugs will subsequently be constructed. Structural studies of DNA and DNA:Ligand interactions usig NMR spectroscopy will provide a starting point for rational molecular design and combinatorial chemistry. Designed compounds will be evaluated in a proprietory DNA-binding assay system, by DNA footprinting, and in various in vitro functional assays.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences physical sciences optics spectroscopy absorption spectroscopy
- medical and health sciences clinical medicine oncology
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SK11 0JL Macclesfield
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.