Objective
Crystallogenesis is a major and rate limiting step in macromolecular structure determination by X-ray crystallography. It is currently the subject of major new research initiatives in countries such as the USA and Japan, and, in order to compete it is vital that similar strategic initiatives also be pursued within Europe, to coordinate research that focuses upon the essential problems of crystallogenesis and crystal quality. This proposal aims to provide a framework within which a collaborative and coordinated multi-disciplinary research effort will be established. It will tackle the different areas of crystallogenesis such as solution studies, nucleation, and crystal growth and assessment from a number of different viewpoints and will exploit a range of different techniques appropriate for each particular area of study. The complex interplay of the different aspects of crystallogenesis that make any isolated approach to this problem so difficult will be addressed, with the collective support of this academic and industrial partnership affording each participating group a greater ability to further their own research within the project. The scale of such a project is apparent in the number of milestones and deliverables described within this proposal, and fully justifies the large number of partners. Several European laboratories already involved in research at the forefront of these areas, are amongst the partners in this proposal. Both the fundamental and practical aspects of crystallogenesis will be dealt with. A rich diversity of viewpoints drawn from the academic and industrial sectors will provide a fertile research base upon which a fruitful partnership can be built, exploiting the synergies between the interrelated areas of the project. The techniques associated with the vital crystallogenesis step in structure determination will be improved by the collective and multi-disciplinary research effort in this currently poorly understood area. Control of the crystallization process by biochemical engineering of the systems under study will be made possible, based upon the results of this research. Finally, a real assessment of the success of these approaches will be undertaken in the subsequent steps of data collection and structure determination, using the crystalline samples that are yielded by these new and improved methods.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- engineering and technologymaterials engineeringcrystals
- engineering and technologychemical engineeringbiochemical engineering
- natural sciencesearth and related environmental sciencesgeologymineralogycrystallography
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Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
07745 JENA
Germany