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Content archived on 2024-04-30

Mobile elements contribution to bacterial adaptability and diversity

Objective



Mobile genetic elements (MGE) are ubiquitous and represent the particularly fluid part of the bacterial genome. They are assumed to contribute to bacterial diversity and adaptability in response to environmental changes. MGE endow their bacterial host with genetic variability needed to successfully colonize ecological niches. MGE form an important part of the horizontal gene pool which can be shared by different bacterial populations. Thus, MGE play a key role in the horizontal spread of antibiotic resistance genes. The present knowledge on the molecular biology of MGE is limited to a few representatives of the bacterial kingdom. The ecology of these plasmids is even less understood. Recent advances in methods to isolate and detect MGE independently from the culturability of their hosts have opened a new dimension in our ability to characterize the horizontal gene pool. The proposed concerted action links together the expertise of European scientists working on the molecular biology and ecology of mobile genetic elements. The concerted action aims to gain a better knowledge on the prevalence and diversity of MGE in bacterial populations, on MGEs' maintenance and transfer functions in an ecological context and on the mechanisms of gene acquisition and spread. A better understanding of the molecular biology and ecology of MGE is important for the safe application of genetically modified microorganisms and will considerably improve the potential to exploit the genetic resources located on MGE for biotechnology.
Two symposia, three workshops and short-term exchanges are planned to reach the objectives of the concerted action. This concerted action complies with the BIOTECHNOLOGY programme objectives under sections 7.2.1 and 7.4.3.

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CON - Coordination of research actions

Coordinator

Biologische Bundesanstalt für Land- und Forstwirtschaft
EU contribution
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Address
Messeweg 11-12
38104 Braunschweig
Germany

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