Objective
We have recently demonstrated that peptide mimics, i.e. mimotopes, selected through the screening of phage-displayed peptide libraries using a protective monoclonal antibody directed against a carbohydrate antigen of an intestinal pathogen, induce upon immunization anti-carbohydrate antibodies. Therefore, mimicking of non-protein ligands can be achieved through screening random peptide libraries where the specific sequences are identified using a purely combinatorial approach, without any structural information of the original target. These data suggest that a novel class of subunit vaccines to polysaccharide antigens, based on the use of selected mimotopes as immunogens, might be developed. The proposed project plans to evaluate this mimotope-based subunit vaccine strategy for two human intestinal pathogens. Its unique and essential feature is to propose the development of anti-polysaccharide vaccines which do not require knowledge on, purification or synthesis of the original target. The proposed project cannot be carried out by a single research group. The best chance of success is through the development of a transdisciplinary network that involves groups with expertise in molecular genetics of and immunity to pathogens, in phage-displayed peptide technology, in delivering of immunogens for the induction of systemic as well as mucosal immunity, and in adjuvant molecules. The transeuropean network we propose here is more than the simple sum of its composing groups of experts. It proposes a synergistic and creative collaboration which represents the only way to efficiently tackle modern vaccinology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- natural sciences biological sciences molecular biology molecular genetics
- medical and health sciences basic medicine immunology immunisation
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- natural sciences biological sciences biochemistry biomolecules carbohydrates
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75724 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.