Objective
The objective of the project is to demonstrate the technical viability and superiority of a new in-vitro test for excitotoxicity based on early response gene measurement.
In previous EU BRIDGE and BIOTECH-1 research contracts (CT-900182 and CT 930224), some of the applicants (Partner B and 2 sub-contractors) have shown that delayed but progressively elevated c-fos mRNA expression is associated with excitotoxicity and that a ratio measurement of c-fos expression at 240/30 min after toxic insult of mouse neuronal primary cultures correlates with excitotoxic outcome. This has been shown to form the basis for a simple in-vitro assay using c-fos mRNA levels as a predictive index. This in vitro test has a significant in vivo relevance because sustained c-fos expression has been shown to be associated with neuronal apoptosis and developmental failures.
Thus we have established original and novel research results which have allowed us to develop an in vitro toxicity test for use in the screening of chemical compounds for their toxicological and pharmacological potential.
The proposal content is intended to prove the technical viability and superiority of the new test in regard to:
- reproducibility, reliability and robustness for technology transfer, - existing methods used to indicate excitotoxicity, - proving the test in comparison to other assay methods, formats and end-points, - proving the test in an industrial context.
In this manner at the end of the project we will have accumulated data on these aspects of the new test, and will have disseminated this information to an extended audience of scientists, regulatory bodies, Industry Platform, ECVAM and European Industry.
The partners in this project include the inventors, three end-users, a synthetic organic chemistry group and an experienced technology exploitation/management team as coordinator. The participation of this multi-disciplinary grouping will ensure a successful outcome of the project.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
2 Dublin
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.