Objective
The aim of this project is to perfect a living human skin equivalent using advanced culture procedures and to validate it as reliable predictive in vitro system for human skin pharmaco-toxicology.
Human skin was the first organ to be reconstructed in vitro and is likely to provide a predictive system for evaluating drug efficacy and toxicity, avoiding animal experimentation. organogenesis in vitro for pharmacological studies is a very new and promising field of investigation.
Culturing cells in close contact with their physiological matrix molecules and with cell types usually adjacent in vivo, cells have been shown to communicate and differentiated in this skin equivalent. These cell-matrix-cell interactions greatly modify the response to pharmaco-toxicological agents, resembling the situation in vivo and demonstrating that some pharmaceutical agents operate on the cell-cell and cell-matrix communication system.
To achieve our goal, the collaboration begun during a previous BAP programme will be reinforced in order to study the role of cell-matrix and cell-cell interactions in differentiation processes and in pharmacological responses.
The validation of these models with a possible transfer to industry to screen the activity of drugs on a large scale is expected for wound healing promoters, antipsoriatic drugs, pigmentogenic, antineoplastic and anti-ageing substances in the next four years.
In addition, this concept of organogenesis in vitro, allowing pharmaco-toxicology at the cellular communication level, will identify pathways that might represent targets for drugs of high socioeconomic value.
This first human organ reconstructed in vitro can be considered as a prototype. Most of the technical innovations made with the skin model could be applied to the reconstruction of other organs such as blood vessels, ligaments, endocrine glands, etc.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine toxicology
- medical and health sciences basic medicine pharmacology and pharmacy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75475 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.