Development of second generation vaccines against parvoviruses

Project Information

Grant agreement ID: BIOT0256

Project closed

Start date 1 February 1991

End date 31 January 1994

Funded under

• Specific research and technological development programme (EEC) in the field of biotechnology (BRIDGE), 1990-1994

Total cost

No data

EU contribution

No data

Coordinated by

INMUNOLOGIA Y GENETICA APLICADA SA
Spain

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Exploitable results

Design of synthetic (peptide) molecules that mimic the binding sites ligand and receptor or antigen and antibody)

For canine parvovirus a peptide was defined, using PEPSCAN, which is able to induce full protection in the target animal (ie canines and mink). This is the first example of a fully synthetic vaccine able to induce full protection. The same peptide was used to be exposed on a recombinant plant virus (CPMV). This recombinant plant virus was shown to protect the target animal fully against disease. As such this is the first plant produced vaccine that is shown to protect the target animal.