Objective
To create a network resource between european scientists already involved in the investigation of the basic molecular and cellular mechanisms of precondition, stunning, hibernation and remodelling. The network will be utilized to define a unified terminology and protocols, as well as experimental and clinical procedures to be followed by the partners. This will provide a large database and registry of scientific information, including a bank of experimental sources for specialized analysis in individual laboratories.
There are several possible outcomes of myocardial ischaemia which have been named 'stunning', 'hibernation' and 'remodelling'. Although all these new ischaemic syndromes have in common a left ventricular dysfunction, the underlying pathophysiology is different and not yet fully understood. Treatment is also different. It has been recognized that a short period of ischaemia can protect the heart against subsequent lethal ischaemic injury. This condition has been termed 'ischaemic preconditioning'. The pathophysiology behind this syndrome is also unknown. Lack of understanding is in large part due to the immense complexity of these different and yet related conditions.
In particular it will be determined: 1) for ischaemic preconditioning: the role of adenosine, Protein Kinase C (PKC), myocardial G proteins, K+-ATP channels, heat-stress proteins, stretch, microvascular dysfunction, endothelium-derived substances, bradikinines, platelet and leucocyte accumulation; 2) for stunning: the role of oxygen free radicals, mitochondrial DNA damage, reduced sensitivity of the myofilaments to calcium, abnormalities of the GAP junction and of cell surface; 3) for hibernation: it will be determined whether this represents an adaptive or a degenerative phenomenon and what are the biochemical, ultrastructural and electrophysiological alterations; 4) for remodelling: it will be determined the role of interaction between the ischaemic dysfunction area with the normal hypertrophied myocardium and the molecular changes occurring in this condition.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- medical and health sciences basic medicine physiology pathophysiology
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences molecular biology
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
25064 Gussago Brescia
Italy
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