Objective
- To conduct a clinical trial on beta cell transplantation in diabetic patients with the purpose of identifying graft and recipient conditions which favour survival of beta cell allograft prepared from donor pancreata.
- To develop alternative sources for beta cell grafts with the purpose of increasing the availability of donor tissue for transplantation in diabetic patients.
The long term goal of the project is to develop a cure for diabetes by implantation of insulin-producing b cells.
The working hypothesis is that successful transplantation of islet beta cells in man requires standardized preparation of purified grafts with selected size, composition and function. The cell biologic properties of the grafts should be adjusted to the metabolic and immunologic status of the recipient. Purified grafts are expected to increase the efficacy of accompanying measures against (auto)immune reactivity.
Human pancreata are procured by 15 European transplantation centres of our network and are shipped, together with blood and donor data, to the central unit in Brussels. Donor organs are processed at the central facility in Brussels, according to international regulations for handling material intended for implantation in man. For each donation, pancreatic and blood samples are taken for morphologic, toxicologic and microbiologic control as well as for storage; genetic, medical and laboratory information of the donor is collected and stored.
Human beta cell isolation proceeds via the methods which have been developed for laboratory animals. The isolated beta cells fulfil all basic requirements of viability and glucose-regulated functions. Each isolated beta cell preparation will be characterized by quality control data which assess the morphologic and functional state of the cells.
A clinical trial is planned to start in 1993. The purpose of this trial is to test the usefulness of purified beta cell grafts which have been composed on the basis of cell biologic parameters. An expert committee will outline protocols for the clinical trial of islet cell grafts, defining patient selection, surgical act, drug treatment, follow-up. This protocol will be submitted to the national and local ethical committees and to the participating centres. Grafts will be distributed from the central unit to the islet cell transplant centres through Eurotransplant/Bio Implant Services. The clinical trial is coordinated by the central unit where data of donors, recipient and grafts are stored.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences clinical medicine transplantation
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
2300 RC Leiden
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.