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Research of genetic factors predisposing to rheumatoid arthritis

Objective

To collect in Europe rheumatoid arthritis (RA) families :

- with affected sib-pairs to map RA susceptibility loci
- with RA cases and both parents for linkage disequilibrium mapping of the genes involved.

Rheumatoid arthritis (RA) is a chronic arthritis with a prevalence of 0.5% in adults. There is a genetic predisposition to this multifactorial disease. Association with HLA class II antigens accounts for a third of it. The aim of the project is to localize the other genes involved, taking advantage of the new dense map of the human genome. Thanks to the collaboration between 7 European states, 330 affected sib-pair families and 230 families with RA cases and both parents will be collected. The GENETHON facilities will be used for genotyping 400 evenly spaced highly polymorphic markers in affected sib-pair families. The genotype analysis will allow susceptibility loci, showing an excess of allele sharing by affected sib-pairs, to be roughly localized. Association studies with markers of these loci, using the families with both parents, will then be performed for linkage disequilibrium mapping of the genes involved. The understanding of the genetic predisposition to RA should allow a breakthrough in the understanding of the pathophysiology of this crippling disease, leading to a therapeutic improvement.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

Université de Paris VII
Address
6,Rue Guy Patin
75475 Paris
France

Participants (9)

Athens General Hospital
Greece
Address
154,Mesogion
11527 Athens
GENETHON III
France
Address
Rue De L'internationale 1Bis
91002 Evry
HLA ET MÉDECINE
France
Address
15,Rue De L'ecole De Médecine 15
75006 Paris
Institut National de la Santé et de la Recherche Médicale
France
Address
1,Avenue Claude Vellefaux
75475 Paris
Katholieke Universiteit Leuven
Belgium
Address
1,Weligerveld
3212 Pellenberg
Katholieke Universiteit Nijmegen - Stichting Katholieke Universiteit
Netherlands
Address
Geert Grooteplein
6525 GA Nijmegen
Universidad Autónoma de Madrid
Spain
Address
261,Paseo De La Castellana
28010 Madrid
Universidade do Porto
Portugal
Address
Alameda Hernani Monteiro
4100 Porto
Università degli Studi di Pisa
Italy
Address
67,Via Roma
56126 Pisa