Objective
Several aspects of decision-making in a cell are to be addressed in the proposed program, starting from the expression and action of receptors for selected growth factors implicated in neuronal development, via signal-transducing proteins, to specific transcription factors. The growth factors of primary focus are nerve growth factor (NGF) and Insulin-like growth factor -1 (IGF-1). These studies should permit the clarification of the cell cycle specificity of NGF action, opening the way for more precise analysis of this growth factors' effects on proliferation, differentiation and survival of neuronal cell types. In the area of apoptosis, the identification of the IGF-1 and NGF survival pathways and the elucidation of the role of known viral and non-viral proteins in prevention of apoptosis will also be of significant import and impact.
Scientific context:
During development, cells are confronted with various extracellular signals that determine their fate. The precise sculpturing of an organism requires careful orchestration of proliferation, differentiation and apoptosis. Furthermore, in the adult animal, extracellular signals are essential for survival and the maintenance of the differentiated state
Several aspects of decision-making in a cell are to be addressed in the proposed program, starting from the expression and action of receptors for selected growth factors implicated in neuronal development, via signal-transducing proteins, to specific transcription factors. The end result of the signal transduction being proliferation, differentiation or maintenance of the differentiated state in models for neuronal differentiation, these studies should, in the very least, clarify the role of some key regulatory proteins in the anti-mitogenic, differentiation and survival (anti-apoptotic) effects of the growth factors studied.
The growth factors of primary focus are nerve growth factor (NGF) and Insulin-like growth factor-1 (IGF-1). These studies should permit the clarification of the cell cycle specificity of NGF action, opening the way for more precise analysis of this growth factors' effects on proliferation, differentiation and survival of neuronal cell types. The fact that the NGF receptors (TrkA and p75LNFR) are members of two families of neurotrophic factor receptors, one can hope that the conclusions drawn from the proposed program may at least serve as a model for the study of other members of the families. In the area of apoptosis, the identification of the IGF-1 and NGF survival pathways and the elucidation of the role of known viral and non-viral proteins in prevention of apoptosis will also be of significant import and impact.
Public Health context:
Increasing appearance of neurodegenerative disorders due to increased longevity (population ageing). Neurodegenerative diseases not linked to the ageing process (e.g. diabetes related). Neuronal cancers. Potential for establishing the scientific basis for novel therapies for treatment of neurodegenerative diseases and neuronal-linked cancers.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69364 LYON
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.