Objetivo To develop the three new key components which have been identified by the clinical evaluation as necessary extensions to a Diabetic Insulin Advisory System (DLAS) to accommodate individual lifestyles and to represent diabetes-specific physiology:- modelling of metabolic processes occurring after hypoglycaemia- processing of data related to physical exercise- consideration of food composition.Diabetes is a major chronic disease widely prevalent throughout the EU and the rest of the world. It is estimated to affect 3-10% (including undiagnosed cases) of the population in Western Europe, and to require 10% out of the total health care budget including cost of diabetes related problems. It occurs in two forms, insulin-dependent diabetes (IDDM - 15% cases) and non-insulin dependent diabetes (NIDDM - 85% cases). The former requires regular insulin injections to be administered (2 injections per day) to maintain blood glucose within safe levels. Studies have shown that the percentage of patients that are able to achieve a desirable level of control is highly variable throughout Europe (10 to 70%).Results of a recent major long-term study in the USA concluded that improvements in the control of blood glucose level lead to a substantial reduction in the rate of complications associated with diabetes (blindness, kidney failure, heart attacks, and gangrene). However, this can be difficult using conventional means due to the physiological effects of patients' varying behaviours and lifestyles, which result in day-today differences in insulin requirements and increased risk of low blood glucose concentration (hypoglycaemia).Previous research by the investigators has led to the development of DIAS. This comprises a computer system based on advanced modelling technology incorporating Causal Probabilistic Networks (CPNs). DIAS provides advice on the amount of insulin to be injected by patients with IDDM based on the dietary data and blood-glucose measurements. Recent clinical studies performed in Denmark and the UK have provided proof of concept. They indicated a tangible clinical benefit. DIAS was able to stabilise diabetic control and recognise nocturnal hypoglycaemia. This clinical evaluation, however, highlighted the need for additional developments of the system prior to its routine use by clinicians and, ultimately, by patients in their home setting.The research methodology will involve model formulation, implementation, and validation using CPNs. Physiological information obtained from clinical literature and from metabolic studies will be incorporated into the system as parameterised data and system knowledge. The three new DIAS extensions will be developed, verified through clinical laboratory studies. Ámbito científico medical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesclinical medicinecardiologycardiovascular diseasesmedical and health sciencesbasic medicinephysiology Programa(s) FP4-BIOMED 2 - Specific research, technological development and demonstration programme in the field of biomedicine and health, 1994-1998 Tema(s) 2.2 - Imaging systems and other devices for diagnosis and therapy Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador City University Aportación de la UE Sin datos Dirección Northampton Square EC1V 0HB London Reino Unido Ver en el mapa Coste total Sin datos Participantes (5) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo Judex Datasystemer A/S Dinamarca Aportación de la UE Sin datos Dirección 8,Lyngvej 8 9000 Ålborg Ver en el mapa Coste total Sin datos UNIVERSITA DEGLI STUDI DI PERUGIA Italia Aportación de la UE Sin datos Dirección Via Enrico Dal Pozzo 06126 PERUGIA Ver en el mapa Coste total Sin datos United Medical and Dental Schools of Guy's and St Thomas's Hospitals Reino Unido Aportación de la UE Sin datos Dirección Lambeth Palace Road SE1 7EH London Ver en el mapa Coste total Sin datos University of Salford Reino Unido Aportación de la UE Sin datos Dirección The Crescent M5 4WT Salford Ver en el mapa Coste total Sin datos Ålborg Universitet Dinamarca Aportación de la UE Sin datos Dirección 7 D,Fredrik Bajersvej 7 D 9220 Ëlborg Ver en el mapa Coste total Sin datos