Objective
Elucidation of the role of apo E and its receptors in inter- and intracellular signalling within the AD brain. Given that apo E has a crucial role in the local redistribution of lipids during nerve injury and repair, the research will unravel major aspects of the pathophysiology of central nervous tissue damage and regeneration. The role of lipoprotein receptors and lactoferrin will address immunological mechanisms of neurological disorders.
To elucidate pathogenesis of Alzheimer's disease, advantage is taken of the participants expertise in lipoprotein metabolism, brain cell metabolism and signal transduction in nerve cells. The factors governing the regulation of the expression of apoE (and variant forms E2, E2, and E4) in astrocytes will be explored. A set of cells to be characterised for apoE metabolism and the receptors therefore (C6 glial cells, a glia-like cell line (U373)) and astrocyte rich primary cultures, neuron like cell lines (PC12), hNT-neurons and hippocampal neurons of Banker-cultures will be characterised and distributed.
These tools will be used to characterise in detail the interaction of variant forms of apo E with constituents of the extracellular matrix in the nervous system such as A4/beta and heparan sulphate proteoglycans. They will allow to define the receptor mediated pathways and their regulation serving the delivery of variant forms of apo E into glial and neuronal cells. As a result the effects of variant forms of apo E on the processing of normal and mutant amyloid precursor proteins as well as possible intracellular effects of apo E on the structure and function of the cytoskeleton, can be elucidated. Results hinting that apo E variants differentially influence neuronal survival will finally direct research towards therapeutic studies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine neurology dementia alzheimer
- natural sciences biological sciences cell biology cell signaling
- medical and health sciences basic medicine physiology pathophysiology
- natural sciences biological sciences cell biology cell metabolism
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1090 VIENNA
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.