Objective
- To elucidate the aetiology of the impaired muscle function in old age.
- To determine how age-related impairments in muscle function are affected by medical intervention and physical activity.
- To design improved regimes which will decrease the dependency and improve the quality of life of the elderly.
This European transdisciplinary research project will be focused on the aetiology of age-related impairments of skeletal muscle function and the possibilities of reducing these impairments, by hormone replacement therapy and physical activity, to improve the quality of life of the aged. The project will be a combination of basic and clinical research and different experimental techniques will be used to study the effects of ageing on factors ranging from the regulation of muscle protein synthesis at the gene level to muscle function and structure in vivo, and the influence of gender, activity/inactivity and hormone replacement therapy on these effects:
1) Molecular biological techniques will be used to study the regulation of contractile protein synthesis at the gene/mRNA level.
2) In vitro motility assays will be performed to study the interaction between myosin and actin.
3) Biochemical techniques will be used to investigate the expression of contractile, regulatory and structural proteins and the sarcoplasmic reticulum in the muscle cell, motor unit and whole muscle.
4) Cell biological techniques will be applied for analysing the regulatory/modulatory influence of myosin isoforms on the contractility in single muscle cells.
5) Physiological and morphological techniques will be used to study muscle physiology and structure in vivo and their relation to the results at the cellular and molecular levels.
6) Clinical studies will be undertaken to examine the effects of hormone replacement therapy and physical activity/inactivity on skeletal muscle from the gene level to muscle function in vivo.
The project concerns age-related changes in skeletal muscle in man, but for comparison, studies will also be performed in small laboratory mammals.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine physiology
- natural sciences biological sciences zoology mammalogy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
171 76 Stockholm
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.