Objective
The major objective of the program is to design, to develop pharmaceutically, and to assess the clinical utility of antagonists of the histamine H3-receptor (H3R) as cognitive enhancers in elderly subjects, particularly patients with Alzheimer disease.
Animal behavioural and human neuropathology data suggest that H3R antagonists, a novel class of drugs never submitted to clinical trials so far, hold promise in the field of Alzheimer's disease. They enhance histaminergic neurotransmission in the CNS, improve wakefulness and learning in animals, and histaminergic neurones seem largely spared in Alzheimer brain. Hence a novel therapeutic strategy based upon cognitive enhancement via facilitation of histamine release from relatively spared neurones.
In the present program the scientific basis for the alleged therapeutic application will be set up by i) cloning the human H3R and using it to assess the activity of already available and future, rationally-designed H3R antagonists, ii) assessing the status of the histamine receptor subtypes in Alzheimer brain by post-mortem neuropathology and PET Scan studies, two approaches for which novel probes will be developed, iii) assessing the cognitive-enhancing activity of selected H3R antagonists drugs on animal models of wakefulness, attention and learning.
The pharmaceutical development, undertaken by a novel pharmaceutical research SME, will comprise in vitro and in vivo toxicity studies, pharmacokinetics and clinical studies up to Phase II in order to validate the alleged indication.
The present project has high chances of success in spite of its novelty and short time schedule. Indeed, it involves a number of partners who i) were at the origin of the discovery of the histamine H2 and H3 receptors and design of their first ligands and radioligands, ii) are accustomed to work together on similar projects and to design and develop rapidly novel classes of drugs.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology dementia alzheimer
- medical and health sciences basic medicine pharmacology and pharmacy pharmacokinetics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75014 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.