Objective
The objectives of the project is to search the human genome systematically for genes predisposing to the vulnerability of the clinical manifestation of schizophrenia. Large schizophrenia pedigrees in geographic isolates, one in Sweden and one in Finland, are investigated using a dense linkage map. This is a unique situation which in addition to linkage analysis in families with several affected members, also allows association and sibpair analysis of candidate gene regions as well as a search of the whole genome with random markers.
The precise nature of the genetic vulnerability would lead to the possibilities of developing more effective drugs for treatment and prevention of schizophrenia.
Schizophrenia is a severe mental disorder with unknown cause affecting nearly 1 % of the human population world-wide. The genes responsible for the susceptibility are unknown. In search for schizophrenia susceptibility gene a genome screening strategy is applied. Significant loci are being analysed in two powerful schizophrenia kindreds from Sweden and Finland in order to replicate and/or to discover schizophrenia susceptibility genes not found in other populations. It can be assumed that the settlements in Northern Sweden and Finland took place about 20-40 generations ago. A relatively small number of founders brought with them a limited selection of genes predisposing to schizophrenia. A linkage disequilibrium between these genes and genetic markers in the vicinity of them has been maintained for hundreds of years and can presumably still today be detected even at a genetic distance of 5 cM. Preliminary results of a genome-wide search in schizophrenia suggest that at least five different chromosomes - 6, 8, 9, 20 and 22 - seem to be involved. The locus heterogeneity and suggestive oligogenic transmission in schizophrenia are being further tested in the large pedigrees.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine psychiatry schizophrenia
- natural sciences biological sciences genetics chromosomes
- natural sciences biological sciences genetics genomes
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Coordinator
171 76 Stockholm
Sweden
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