Objective
To search systematically for morphogenic genes (gene disruption by transposon insertion, differential mRNA display)
To analyse the early events in morphogenesis involved in the regulation of the cell cycle and the transcription regulation
To analyse the late events, e.g. the establishment of cell polarity by the actin cytoskeleton, vesicle transport and regulation of cell wall synthesis
Candida albicans is the most common fungal pathogen of humans. It is capable of a dimorphic transition between two growth forms. The hyphal form appears well adapted to penetrate epithelia, and hence this growth form probably plays an important role in the progression from superficial to deep-seated infections. However, the molecular mechanisms by which hyphal growth is controlled in C. albicans remain obscure. This is partly due to the genetic intransigence of C. albicans which is diploid and asexual. However, the recent development of new tools for the molecualr dissection of this yeast is now allowing rapid progress which will bear fruit in the near future.
Yarrowia lipolytica also provides a valuable model to study the regulation of fungal dimorphism. Like C. albicans it is dimorphic, but it is an apathogenic yeast which has been under genetic and molecular investigation for several years. Involvement of Y. lipolytica will definitely increase the scientific value of the project, because like C. albicans, its hyphae are different structurally to the pseudohyphae of S. cerevisiae. Conclusions made from results obtained on S. cerevisiae are not always directly applicable to C. albicans.
In this context the subprojects will study one specific aspect of morphogenesis, i.e. the regulatory hierarchy that controls the switch from a yeast cell to a hypha. The individual groups will collaborate in three complementary lines of investigation, indicated on the top of this page.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- agricultural sciences agriculture, forestry, and fisheries agriculture horticulture fruit growing
- natural sciences biological sciences microbiology mycology
- natural sciences biological sciences cell biology cell polarity
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
07745 Jena
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.